Results 1 to 10 of about 149 (149)
The Thymus and Central Tolerance [PDF]
Clinical Immunology, 2000 T–cell differentiation in the thymus generates a peripheral repertoire of mature T cells that mounts strong responses to foreign antigens but is largely unresponsive to self–antigens. This state of specific immunological tolerance to self–components involves both central and peripheral mechanisms.
Jonathan Sprent, Hidehiro Kishimoto
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Central Tolerance Matters [PDF]
Immunity, 2005 In this issue of Immunity, Anderson et al. provide another clue to the riddle that is Aire--why do human beings and mice lacking Aire develop diffuse and pathogenic autoimmunity? They find that Aire influences central tolerance not only by promoting the expression of peripheral self-proteins in thymic medullary epithelial cells (MECs) but also by ...
Ananda W. Goldrath, Stephen M. Hedrick
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Back to Central Tolerance [PDF]
Immunity, 2004 The establishment and maintenance of immunological tolerance entails both central and peripheral mechanisms. The latter have been highlighted in the past several years, mostly because of great interest in the activities of regulatory T cells. However, an important role for central tolerance mechanisms has been reemphasized by recent results on human ...
Christophe Benoist, Diane Mathis
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T cell tolerance to the skin: a central role for central tolerance [PDF]
Seminars in Immunopathology, 2007 T cell tolerance to self-antigens is believed to be achieved in a two-step process. The first step, called central tolerance, takes place in the thymus. The second step takes place outside the thymus in secondary lymphoid organs. One may ask why two mechanisms are needed to insure T cell tolerance.
Schuler, Prisca +2 more
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T-Cell Tolerance: Central and Peripheral [PDF]
Cold Spring Harbor Perspectives in Biology, 2012 Somatic recombination of TCR genes in immature thymocytes results in some cells with useful TCR specificities, but also many with useless or potentially self-reactive specificities. Thus thymic selection mechanisms operate to shape the T-cell repertoire. Thymocytes that have a TCR with low affinity for self-peptide-MHC complexes are positively selected
Kristin A. Hogquist, Yan Xing
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The Many Faces of Aire in Central Tolerance [PDF]
Frontiers in Immunology, 2013 Although the role that Autoimmune Regulator (Aire) plays in the induction of central tolerance is well known, the precise cellular and molecular mechanisms are still unclear and debated. In the prevailing view, Aire serves mainly as a direct inducer of tissue-specific antigens.
Laan, Martti, Peterson, Pärt
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Normothermic central hypovolemia tolerance reflects hyperthermic tolerance [PDF]
Clinical Autonomic Research, 2014 To test the hypothesis that those who are highly tolerant to lower body negative pressure (LBNP) while normothermic are also highly tolerant to this challenge while hyperthermic.Sixty pairs of normothermic and hyperthermic LBNP tests to pre-syncope were evaluated.
Craig G. Crandall +3 more
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The Role of Dendritic Cells in Central Tolerance [PDF]
Immune Network, 2015 Dendritic cells (DCs) play a significant role in establishing self-tolerance through their ability to present self-antigens to developing T cells in the thymus. DCs are predominantly localized in the medullary region of thymus and present a broad range of self-antigens, which include tissue-restricted antigens expressed and transferred from medullary ...
Jaehak Oh, Jeoung-Sook Shin
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Central tolerance promoted by cell chimerism
Proceedings of the National Academy of Sciences, 2022 Historically, successful allotransplantation was only achieved by utilizing powerful immunosuppressive drugs that were exposing the patient to severe opportunistic infections. The thymus of the transplant recipient renders such therapy obligatory as it constitutively blocks self-reactive T cells while allowing alloreactive T cells to mature and ...
Ann Zeleniak, Massimo Trucco
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Control of central and peripheral tolerance by Aire [PDF]
Immunological Reviews, 2011 Summary: The negative selection of self‐reactive thymocytes depends on the expression of tissue‐specific antigens by medullary thymic epithelial cells. The autoimmune regulator (Aire) protein plays an important role in turning on these antigens, and the absence of even one Aire‐induced tissue‐specific antigen in the thymus can lead to autoimmunity in ...
Todd C. Metzger, Mark S. Anderson
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