Age-Related Changes in Thymic Central Tolerance [PDF]
Frontiers in Immunology, 2021 Thymic epithelial cells (TECs) and hematopoietic antigen presenting cells (HAPCs) in the thymus microenvironment provide essential signals to self-reactive thymocytes that induce either negative selection or generation of regulatory T cells (Treg), both ...
Jayashree Srinivasan +6 more
doaj +5 more sources
Central tolerance promoted by cell chimerism. [PDF]
Proc Natl Acad Sci U S A, 2022 Historically, successful allotransplantation was only achieved by utilizing powerful immunosuppressive drugs that were exposing the patient to severe opportunistic infections. The thymus of the transplant recipient renders such therapy obligatory as it constitutively blocks self-reactive T cells while allowing alloreactive T cells to mature and ...
Zeleniak A, Trucco M.
europepmc +5 more sources
CCR4 and CCR7 differentially regulate thymocyte localization with distinct outcomes for central tolerance [PDF]
eLife, 2023 Central tolerance ensures autoreactive T cells are eliminated or diverted to the regulatory T cell lineage, thus preventing autoimmunity. To undergo central tolerance, thymocytes must enter the medulla to test their T-cell receptors (TCRs) for ...
Yu Li +5 more
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The many faces of Aire in central tolerance [PDF]
Frontiers in Immunology, 2013 Although the role that Autoimmune Regulator (Aire) plays in the induction of central tolerance is well known, the precise cellular and molecular mechanisms are still unclear and debated.
Martti eLaan, Pärt ePeterson
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Thymic B cells and central T cell tolerance [PDF]
Frontiers in Immunology, 2015 Central T cell tolerance is believed to be mainly induced by thymic dendritic cells and medullary thymic epithelial cells. The thymus also harbors substantial numbers of B cells.
Ludger eKlein +2 more
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Porcine Circovirus Type 2 Pathogenicity Alters Host’s Central Tolerance for Propagation [PDF]
Pathogens, 2020 Porcine circovirus type 2 (PCV2) infections and resulting diseases are a worldwide threat to pig production. PCV2 bears a uniqueness that allows for us to understand more about chronic infections and the immune system in general.
Xaver Sidler +4 more
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Helicobacter pylori outer membrane vesicles mediate central tolerance in C57BL/6J mice offspring T cells via maternal-fetal transmission [PDF]
Frontiers in ImmunologyOuter membrane vesicles (OMVs) released by Helicobacter pylori (H.pylori) can enter the blood circulation of the host and cause extra-gastric lesions such as atherosclerosis and hyperemesis gravidarum.
Yusen Wei +7 more
doaj +2 more sources
Analysis of a miR-148a Targetome in B Cell Central Tolerance [PDF]
Frontiers in Immunology, 2022 A microRNA (miRNA) often regulates the expression of hundreds of target genes. A fundamental question in the field of miRNA research is whether a miRNA exerts its biological function through regulating a small number of key targets or through small ...
Fengge Ma +8 more
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Active PI3K abrogates central tolerance in high-avidity autoreactive B cells. [PDF]
J Exp Med, 2019 Greaves SA +4 more
europepmc +3 more sources
Claudin 1-mediated positioning of DC1 to mTECs is essential for maintenance of central tolerance. [PDF]
J Exp MedBřezina J +24 more
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