Results 11 to 20 of about 149 (149)
Induction of Central Tolerance by Mature T Cells [PDF]
The Journal of Immunology, 2004 Abstract Induction of immunological tolerance is highly desirable for the treatment and prevention of autoimmunity, allergy, and organ transplant rejection. Adoptive transfer of MHC class I disparate mature T cells at the time of reconstitution of mice with syngeneic bone marrow resulted in specific tolerance to allogeneic skin grafts ...
Chaorui Tian +3 more
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Thymic B Cells and Central T Cell Tolerance [PDF]
Frontiers in Immunology, 2015 Central T cell tolerance is believed to be mainly induced by thymic dendritic cells and medullary thymic epithelial cells. The thymus also harbors substantial numbers of B cells. These may arise though intrathymic B lymphopoiesis or immigration from the bloodstream. Importantly, and in contrast to resting "mainstream" B cells in the periphery, thymic B
Yamano, Tomoyoshi +2 more
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Age-Related Changes in Thymic Central Tolerance
Frontiers in Immunology, 2021 Thymic epithelial cells (TECs) and hematopoietic antigen presenting cells (HAPCs) in the thymus microenvironment provide essential signals to self-reactive thymocytes that induce either negative selection or generation of regulatory T cells (Treg), both of which are required to establish and maintain central tolerance throughout life.
Jayashree Srinivasan +6 more
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Myocarditis: a defect in central immune tolerance? [PDF]
Journal of Clinical Investigation, 2011 Myocarditis, or inflammation of the heart, is a potentially devastating disease that can result from both viral infection and autoimmune attack of self antigens in the heart. In the current issue of the JCI, Lv and colleagues use a genetically susceptible mouse model to show that myocarditis is a T cell-mediated autoimmune disease that occurs due to ...
Todd C. Metzger, Mark S. Anderson
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Redefining thymus medulla specialization for central tolerance [PDF]
Journal of Experimental Medicine, 2017 During αβT cell development, the thymus medulla represents an essential microenvironment for T cell tolerance. This functional specialization is attributed to its typical organized topology consisting of a branching structure that contains medullary thymic epithelial cell (mTEC) networks to support negative selection and Foxp3+ T-regulatory cell (T-reg)
Emilie J. Cosway +8 more
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Dendritic cells steering antigen and leukocyte traffic in lymph nodes
FEBS Letters, EarlyView.Dendritic cells are key players in the activation of T cells and their commitment to effector function. In this In a Nutshell Review, we will discuss how dendritic cells guide the trafficking of antigen and leukocytes in the lymph node, thus influencing T‐cell activation processes. Dendritic cells (DCs) play a central role in initiating and shaping the
Enrico Dotta +3 more
wiley +1 more source
Central tolerance to self revealed by the autoimmune regulator [PDF]
Annals of the New York Academy of Sciences, 2015 The autoimmune regulator (Aire) was initially identified as the gene causing multiorgan system autoimmunity in humans, and deletion of this gene in mice also resulted in organ‐specific autoimmunity. Aire regulates the expression of tissue‐specific antigens (TSAs) in medullary thymic epithelial cells (mTECs), which play a critical role in the negative ...
Chan, Alice Y, Anderson, Mark S
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The dual nature of TDC – bridging dendritic and T cells in immunity
FEBS Letters, EarlyView.TDC are hematopoietic cells combining dendritic and T cell features. They reach secondary lymphoid organs (SLOs) and peripheral organs (liver and lungs) after FLT3‐dependent development in the bone marrow and maturation in the thymus. TDC are activated and enriched in SLOs upon viral infection, suggesting that they might play unique immune roles, since
Maria Nelli, Mirela Kuka
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On central max-point-tolerance graphs [PDF]
AKCE International Journal of Graphs and Combinatorics, 2020 Max-point-tolerance graphs (MPTG) were studied by Catanzaro et al. in 2017 and the same class of graphs were introduced in the name of p-BOX(1) graphs by Soto and Caro in 2015. This class has a wide application in genome studies as well as in telecommunication networks.
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FEBS Letters, EarlyView.In vivo IL‐10 produced by tissue‐resident tolDC is involved in maintaining/inducing tolerance. Depending on the agent used for ex vivo tolDC generation, cells acquire common features but prime T cells towards anergy, FOXP3+ Tregs, or Tr1 cells according to the levels of IL‐10 produced. Ex vivo‐induced tolDC were administered to patients to re‐establish/
Konstantina Morali +3 more
wiley +1 more source