Results 11 to 20 of about 1,358,589 (334)

T cell tolerance to the skin: a central role for central tolerance [PDF]

Seminars in Immunopathology, 2018
T cell tolerance to self-antigens is believed to be achieved in a two-step process. The first step, called central tolerance, takes place in the thymus. The second step takes place outside the thymus in secondary lymphoid organs.
Contassot, Emmanuel, Huard, Bertrand, Schuler, Prisca   +2 more
core   +3 more sources

Intraocular human cytomegaloviruses of ocular diseases are distinct from those of viremia and are capable of escaping from innate and adaptive immunity by exploiting HLA-E-mediated peripheral and central tolerance. [PDF]

Front Immunol, 2022
Shirane M, Yawata N, Motooka D, Shibata K, Khor SS, Omae Y, Kaburaki T, Yanai R, Mashimo H, Yamana S, Ito T, Hayashida A, Mori Y, Numata A, Murakami Y, Fujiwara K, Ohguro N, Hosogai M, Akiyama M, Hasegawa E, Paley M, Takeda A, Maenaka K, Akashi K, Yokoyama WM, Tokunaga K, Yawata M, Sonoda KH.   +27 more
europepmc   +3 more sources

Thermal Tolerance Varies Latitudinally and Broadly Mirrors Genetic Structure in the Seaweed Phyllospora comosa Across Its Entire Latitudinal Range [PDF]

Ecology and Evolution
Climate‐driven warming is causing rapid changes in marine environments, contracting ranges and reshaping ecosystems. Understanding how genetic structure and phenotypic variation interact to determine populations' ability to tolerate warming aids in ...
Rosalie J. Harris, Callum Bryant, Andrea Leigh, Melinda A. Coleman, Adrienne B. Nicotra, Georgina Wood   +5 more
doaj   +2 more sources

EBI2 contributes to the induction of thymic central tolerance in mice by promoting rapid motility of medullary thymocytes. [PDF]

Eur J Immunol, 2017
Ki S, Thyagarajan HM, Hu Z, Lancaster JN, Ehrlich LIR.   +4 more
europepmc   +3 more sources

B7-CD28 co-stimulation modulates central tolerance via thymic clonal deletion and Treg generation through distinct mechanisms. [PDF]

Nat Commun, 2020
Watanabe M, Lu Y, Breen M, Hodes RJ.
europepmc   +3 more sources

Pulling RANK on Cancer: Blocking Aire-Mediated Central Tolerance to Enhance Immunotherapy. [PDF]

Cancer Immunol Res, 2019
Su MA, Anderson MS.
europepmc   +3 more sources

Thymic central tolerance takes centre stage in autoimmune disease [PDF]

The Lancet Regional Health. Western Pacific
Smaila Mulic-Al Bunni, Adam E. Handel
doaj   +2 more sources

A model of preferential pairing between epithelial and dendritic cells in thymic antigen transfer

eLife, 2022
Medullary thymic epithelial cells (mTECs), which produce and present self-antigens, are essential for the establishment of central tolerance. Since mTEC numbers are limited, their function is complemented by thymic dendritic cells (DCs), which transfer ...
Matouš Vobořil, Jiří Březina, Tomáš Brabec, Jan Dobeš, Ondřej Ballek, Martina Dobešová, Jasper Manning, Richard S Blumberg, Dominik Filipp   +8 more
doaj   +1 more source

Central Tolerance Matters [PDF]

Immunity, 2005
In this issue of Immunity, Anderson et al. provide another clue to the riddle that is Aire--why do human beings and mice lacking Aire develop diffuse and pathogenic autoimmunity? They find that Aire influences central tolerance not only by promoting the expression of peripheral self-proteins in thymic medullary epithelial cells (MECs) but also by ...
Goldrath, Ananda W., Hedrick, Stephen M.
openaire   +2 more sources

RANK Signaling in the Differentiation and Regeneration of Thymic Epithelial Cells

Frontiers in Immunology, 2021
Thymic epithelial cells (TECs) provide essential clues for the proliferation, survival, migration, and differentiation of thymocytes. Recent advances in mouse and human have revealed that TECs constitute a highly heterogeneous cell population with ...
Magali Irla
doaj   +1 more source