Results 21 to 30 of about 1,358,589 (334)
Molecular Therapy: Methods & Clinical Development, 2022 Insulin is the primary autoantigen (Ag) targeted by T cells in type 1 diabetes (T1D). Although biomarkers precisely identifying subjects at high risk of T1D are available, successful prophylaxis is still an unmet need.
Fabio Russo +8 more
doaj +1 more source
Exploring the Origin and Antigenic Specificity of Maternal Regulatory T Cells in Pregnancy
Frontiers in Immunology, 2020 Successful pregnancy outcome is partially determined by the suppression of reactive effector T cells by maternal regulatory T cells (TRegs) at the maternal-fetal interface.
Soo Hyun Ahn +5 more
doaj +1 more source
Mechanisms of Direct and Indirect Presentation of Self-Antigens in the Thymus
Frontiers in Immunology, 2022 The inevitability of evolution of the adaptive immune system with its mechanism of randomly rearranging segments of the T cell receptor (TCR) gene is the generation of self-reactive clones. For the sake of prevention of autoimmunity, these clones must be
Jiří Březina +2 more
doaj +1 more source
Frontiers in Immunology, 2021 While there is convincing evidence on the role of Aire-positive medullary thymic epithelial cells (mTEC) in the induction of central tolerance, the nature and function of post-Aire mTECs and Hassall’s corpuscles have remained enigmatic. Here we summarize
Martti Laan +7 more
doaj +1 more source
The Role of Viral Infections in the Onset of Autoimmune Diseases
Viruses, 2023 Autoimmune diseases (AIDs) are the consequence of a breach in immune tolerance, leading to the inability to sufficiently differentiate between self and non-self.
Bhargavi Sundaresan +3 more
doaj +1 more source
The Role of Dendritic Cells in Central Tolerance. [PDF]
Immune Netw, 2015 Oh J, Shin JS.
europepmc +3 more sources
Back to Central Tolerance [PDF]
Immunity, 2004 The establishment and maintenance of immunological tolerance entails both central and peripheral mechanisms. The latter have been highlighted in the past several years, mostly because of great interest in the activities of regulatory T cells. However, an important role for central tolerance mechanisms has been reemphasized by recent results on human ...
Mathis, Diane, Benoist, Christophe
openaire +2 more sources
Frontiers in Immunology, 2019 Therapy with alloantigen-specific CD4+CD25+ T regulatory cells (Treg) for induction of transplant tolerance is desirable, as naïve thymic Treg (tTreg) are not alloantigen-specific and are weak suppressor cells.
Nirupama D. Verma +11 more
doaj +1 more source
Association between one-hour post-load plasma glucose levels and vascular stiffness in essential hypertension [PDF]
, 2012 Objectives: Pulse wave velocity (PWV) is a surrogate end-point for cardiovascular morbidity and mortality. A plasma glucose value $155 mg/dl for the 1-hour post-load plasma glucose during an oral glucose tolerance test (OGTT) is able to identify ...
Arturi, F +8 more
core +2 more sources
Normothermic central hypovolemia tolerance reflects hyperthermic tolerance [PDF]
Clinical Autonomic Research, 2014 To test the hypothesis that those who are highly tolerant to lower body negative pressure (LBNP) while normothermic are also highly tolerant to this challenge while hyperthermic.Sixty pairs of normothermic and hyperthermic LBNP tests to pre-syncope were evaluated.
Zachary J, Schlader, Craig G, Crandall
openaire +2 more sources