Results 31 to 40 of about 1,358,589 (334)

The Multifaceted Roles of B Cells in the Thymus: From Immune Tolerance to Autoimmunity

Frontiers in Immunology, 2021
The thymus is home to a significant number of resident B cells which possess several unique characteristics regarding their origin, phenotype and function.
Justine Castañeda, Yessia Hidalgo, Daniela Sauma, Mario Rosemblatt, Mario Rosemblatt, Mario Rosemblatt, María Rosa Bono, Sarah Núñez   +7 more
doaj   +1 more source

What lies beneath: exploring links between asylum policy and hate crime in the UK [PDF]

, 2010
This paper explores the link between increasing incidents of hate crime and the asylum policy of successive British governments with its central emphasis on deterrence.
A Dummett, A Harmit, Administrator, B Bowling, B Perry, British Crime Survey, C Coole, Children’s Commissioner, Crown Prosecution Service, D Coleman, D Frost, D Gadd, D Kahan, DP Green, E Bleich, E Goffman, F Anthias, G Cornelisse, G Mason, G Moon, H Hurd, H O’Nions, Helen O’Nions, Home Office, Human Rights First, Human Rights First, I Dale, ICAR (Information centre about asylum seekers and refugees), Independent Asylum Commission, J Banks, L Dixon, L Fekete, L Ray, M Wetherell, N Hall, O Fiss, O Parker, OG Bailey, OSCE, P Aspinall, P Iganksi, P Tuitt, R Capdevila, R Grillo, R Karapin, R Karapin, R Sibbitt, Refugee Action, Refugee Action, S Goodman, Scottish Executive, T Bjorgo, T Bjorgo, T Bjorgo, T Cantle, T Hayter, T Veenkamp, TA Dijk Van, TA Dijk Van, UNHCR   +59 more
core   +1 more source

The Thymus and Central Tolerance [PDF]

Clinical Immunology, 2000
T–cell differentiation in the thymus generates a peripheral repertoire of mature T cells that mounts strong responses to foreign antigens but is largely unresponsive to self–antigens. This state of specific immunological tolerance to self–components involves both central and peripheral mechanisms.
J, Sprent, H, Kishimoto
openaire   +4 more sources

CCR7 Modulates the Generation of Thymic Regulatory T Cells by Altering the Composition of the Thymic Dendritic Cell Compartment

Cell Reports, 2017
Upon recognition of auto-antigens, thymocytes are negatively selected or diverted to a regulatory T cell (Treg) fate. CCR7 is required for negative selection of auto-reactive thymocytes in the thymic medulla.
Zicheng Hu, Yu Li, Annemarie Van Nieuwenhuijze, Hilary J. Selden, Angela M. Jarrett, Anna G. Sorace, Thomas E. Yankeelov, Adrian Liston, Lauren I.R. Ehrlich   +8 more
doaj   +1 more source

Is T Cell Negative Selection a Learning Algorithm?

Cells, 2020
Our immune system can destroy most cells in our body, an ability that needs to be tightly controlled. To prevent autoimmunity, the thymic medulla exposes developing T cells to normal “self” peptides and prevents any responders from entering ...
Inge M. N. Wortel, Can Keşmir, Rob J. de Boer, Judith N. Mandl, Johannes Textor   +4 more
doaj   +1 more source

Half a century of research on diatoms in athalassic habitats in central Poland [PDF]

, 2015
The authors would like to dedicate this paper to Prof. Marcin Pliński who started the phycological research in these unique habitats of Central Poland.Part of the geology in the Łódź province was formed during the Upper Permian period when rich ...
Nowicka-Krawczyk, Paulina, Olszyński, Rafał, Żelazna-Wieczorek, Joanna   +2 more
core   +1 more source

Thymic Epithelial Cell Alterations and Defective Thymopoiesis Lead to Central and Peripheral Tolerance Perturbation in MHCII Deficiency

Frontiers in Immunology, 2021
Major Histocompatibility Complex (MHC) class II (MHCII) deficiency (MHCII-D), also known as Bare Lymphocyte Syndrome (BLS), is a rare combined immunodeficiency due to mutations in genes regulating expression of MHCII molecules.
Francesca Ferrua, Francesca Ferrua, Francesca Ferrua, Ileana Bortolomai, Elena Fontana, Elena Fontana, Dario Di Silvestre, Rosita Rigoni, Rosita Rigoni, Genni Enza Marcovecchio, Elena Draghici, Francesca Brambilla, Maria Carmina Castiello, Maria Carmina Castiello, Gloria Delfanti, Despina Moshous, Despina Moshous, Capucine Picard, Capucine Picard, Capucine Picard, Tom Taghon, Victoria Bordon, Ansgar S. Schulz, Catharina Schuetz, Catharina Schuetz, Silvia Giliani, Annarosa Soresina, Andrew R. Gennery, Andrew R. Gennery, Sara Signa, Sara Signa, Blachy J. Dávila Saldaña, Ottavia M. Delmonte, Luigi D. Notarangelo, Chaim M. Roifman, Pietro Luigi Poliani, Paolo Uva, Pier Luigi Mauri, Anna Villa, Anna Villa, Marita Bosticardo, Marita Bosticardo   +41 more
doaj   +1 more source

First Record of \u3ci\u3eAphis Helianthi\u3c/i\u3e (Homoptera: Aphididae) as a Pest of Celery [PDF]

, 2017
In 1989, the aphid Aphis helianthi severely damaged five of 10 scouted celery fields in west central Michigan. In 1990 and in 1991, A. helianthi again was a problem. reaching pestiferous levels in three of 10 and two of 10 scouted fields.
Davis, M. G. Kortier, Grafius, E.
core   +2 more sources

Redefining thymus medulla specialization for central tolerance. [PDF]

J Exp Med, 2017
During αβT cell development, the thymus medulla represents an essential microenvironment for T cell tolerance. This functional specialization is attributed to its typical organized topology consisting of a branching structure that contains medullary thymic epithelial cell (mTEC) networks to support negative selection and Foxp3+ T-regulatory cell (T-reg)
Cosway EJ, Lucas B, James KD, Parnell SM, Carvalho-Gaspar M, White AJ, Tumanov AV, Jenkinson WE, Anderson G.   +8 more
europepmc   +4 more sources

Mechanisms of immunological tolerance in central nervous system inflammatory demyelination. [PDF]

, 2015
Multiple sclerosis is a complex autoimmune disease of the central nervous system that results in a disruption of the balance between pro-inflammatory and anti-inflammatory signals in the immune system.
Anderton, Ando, Andres, Apetoh, Astier, Awasthi, Bacchetta, Bacchetta, Barrat, Batten, Bennett, Borsellino, Brunkow, Cedeno-Laurent, Chen, Chen, Dalla Libera, Darrasse-Jeze, David, Dominguez-Villar, Durelli, El-Behi, Faria, Fitzgerald, Fitzgerald, Fitzgerald, Fletcher, Fontenot, Frisullo, Gagliani, Gandhi, Garin, Getts, Getts, Gregory, Groux, Haak, Haas, Haas, Harrington, Hilliard, Hong, Hori, Huan, Huang, Huber, Hunter, Iellem, Ilarregui, Jiang, Joller, Kipnis, Kohm, Komiyama, Kopcow, Korn, Korn, Korporal, Kroenke, Kuniyasu, Langrish, Laouar, Leech, Leonard, Li, Liblau, Lutterotti, Magnani, Mariathasan, Markiewicz, Martinez-Forero, Mascanfroni, McGeachy, Mehling, Miller, Mosmann, Muls, Noseworthy, O'Connor, Ohnmacht, Peng, Pflanz, Pflanz, Pitkanen, Pot, Pot, Pot, Rabinovich, Ramgolam, Ratts, Read, Rostami, Rovetto, Russell, Sakaguchi, Secor, Segal, Sela, Smith, Stephens, Stumhofer, Sundstedt, Takahashi, Takeda, Tigno-Aranjuez, Toscano, Turley, Tzartos, Uyttenhove, Veen, Venken, Venken, Vieira, Viglietta, Villarino, Voskuhl, Wang, Wang, Weiner, Wildbaum, Wildin, Xu, Yamaguchi, Yamazaki, Yang, Yang, Zhang, Zhang, Zhang, Zhang   +129 more
core   +2 more sources