Results 41 to 50 of about 1,358,589 (334)

MHC Class II Presentation in Autoimmunity

Cells, 2023
Antigen presentation by major histocompatibility complex class II (MHC-II) molecules is crucial for eliciting an efficient immune response by CD4+ T cells and maintaining self-antigen tolerance.
Irina A. Ishina, Maria Y. Zakharova, Inna N. Kurbatskaia, Azad E. Mamedov, Alexey A. Belogurov, Alexander G. Gabibov   +5 more
doaj   +1 more source

Conformational Plasticity of HLA-B27 Molecules Correlates Inversely With Efficiency of Negative T Cell Selection

Frontiers in Immunology, 2020
The development of autoimmune disorders is incompletely understood. Inefficient thymic T cell selection against self-peptides presented by major histocompatibility antigens (HLA in humans) may contribute to the emergence of auto-reactive effector cells ...
Bernhard Loll, Christine Rückert, Barbara Uchanska-Ziegler, Barbara Uchanska-Ziegler, Andreas Ziegler   +4 more
doaj   +1 more source

Amphetamine and pseudoephedrine cross-tolerance measured by c-Fos protein expression in brains of chronically treated rats [PDF]

, 2008
Background Pseudoephedrine is a drug commonly prescribed as a nasal decongestant and bronchodilator and is also freely available in cold remedies and medications.
Casalotti, Stefano O., Govitrapong, P., Ruksee, N., Tongjaroenbuangam, W.   +3 more
core   +3 more sources

Interleukin-5 (IL-5) Therapy Prevents Allograft Rejection by Promoting CD4+CD25+ Ts2 Regulatory Cells That Are Antigen-Specific and Express IL-5 Receptor

Frontiers in Immunology, 2021
CD4+CD25+Foxp3+T cell population is heterogenous and contains three major sub-groups. First, thymus derived T regulatory cells (tTreg) that are naïve/resting. Second, activated/memory Treg that are produced by activation of tTreg by antigen and cytokines.
Bruce M. Hall, Bruce M. Hall, Rachael M. Hall, Rachael M. Hall, Giang T. Tran, Giang T. Tran, Catherine M. Robinson, Catherine M. Robinson, Paul L. Wilcox, Paul L. Wilcox, Prateek K. Rakesh, Prateek K. Rakesh, Chuanmin Wang, Alexandra F. Sharland, Nirupama D. Verma, Nirupama D. Verma, Suzanne J. Hodgkinson, Suzanne J. Hodgkinson   +17 more
doaj   +1 more source

Mechanisms of central tolerance for B cells. [PDF]

Nat Rev Immunol, 2017
Immune tolerance hinders the potentially destructive responses of lymphocytes to host tissues. Tolerance is regulated at the stage of immature B cell development (central tolerance) by clonal deletion, involving apoptosis, and by receptor editing, which reprogrammes the specificity of B cells through secondary recombination of antibody genes.
Nemazee D.
europepmc   +4 more sources

Hypothalamic Vitamin D Improves Glucose Homeostasis and Reduces Weight [PDF]

, 2016
Despite clear associations between vitamin D deficiency and obesity and/or type 2 diabetes, a causal relationship is not established. Vitamin D receptors (VDRs) are found within multiple tissues, including the brain.
Arble, Deanna M., Chambers, Adam P., Gardner, David, Gutierrez-Aguilar, Ruth, He, Yanlin, Moore, David D., Sandoval, Darleen A., Seeley, Randy J., Sisley, Stephanie R., Xu, Yong   +9 more
core   +4 more sources

Renal neuroendocrine control of desiccation and cold tolerance by Drosophila suzukii [PDF]

, 2017
Background: Neuropeptides are central to the regulation of physiological, and behavioural processes in insects, directly impacting cold and desiccation survival.
Al-Anzi, Asplen, Atallah, Audsley, Cabrero, Cabrero, Cannell, Choi, Chown, Cini, Coast, Coast, Condon, Dalton, David, Davies, Denlinger, Dow, Dow, Enriquez, Gerken, Gibbs, Goodhue, Hadley, Halberg, Hoffmann, Hoffmann, Huey, Jakobs, Jakobs, Jensen, Kacar, Kahsai, Kang, Kean, Kelty, Li, Matsumura, Matzkin, McWilliam, Nässel, O'Donnell, Plantamp, Poyet, Rajpurohit, Ryan, Schiffer, Schooley, Shearer, Sinclair, Sinclair, Sinclair, Stephens, Sørensen, Taghert, Telonis-Scott, Terblanche, Terhzaz, Terhzaz, Terhzaz, Tochen, Toxopeus, Wallingford, Yeoh   +63 more
core   +2 more sources

The RANKL-RANK Axis: A Bone to Thymus Round Trip

Frontiers in Immunology, 2019
The identification of Receptor activator of nuclear factor kappa B ligand (RANKL) and its cognate receptor Receptor activator of nuclear factor kappa B (RANK) during a search for novel tumor necrosis factor receptor (TNFR) superfamily members has ...
Cristina Sobacchi, Cristina Sobacchi, Ciro Menale, Ciro Menale, Anna Villa, Anna Villa   +5 more
doaj   +1 more source

Increased central artery stiffness in impaired glucose metabolism and type 2 diabetes - The Hoorn study [PDF]

, 2003
Impaired glucose metabolism (IGM) and type 2 diabetes (DM-2) are associated with high cardiovascular disease risk. Increases in peripheral and central artery stiffness may represent pathophysiologic pathways through which glucose tolerance status leads ...
Bouter, L.M., Dekker, J.M., Dijk, R.A.J.M. van, Heine, R.J., Henry, R.M.A., Kostense, P.J., Nijpels, G., Schram, M.T., Stehouwer, C.D.A., Westerhof, N.   +9 more
core   +3 more sources

Design degrees of freedom and mechanisms for complexity [PDF]

, 2002
We develop a discrete spectrum of percolation forest fire models characterized by increasing design degrees of freedom (DDOF’s). The DDOF’s are tuned to optimize the yield of trees after a single spark.
Carlson, J. M., Doyle, John, Reynolds, David   +2 more
core   +1 more source