Results 51 to 60 of about 1,358,589 (334)

T-Cell Tolerance: Central and Peripheral [PDF]

Cold Spring Harbor Perspectives in Biology, 2012
Somatic recombination of TCR genes in immature thymocytes results in some cells with useful TCR specificities, but also many with useless or potentially self-reactive specificities. Thus thymic selection mechanisms operate to shape the T-cell repertoire. Thymocytes that have a TCR with low affinity for self-peptide-MHC complexes are positively selected
Yan, Xing, Kristin A, Hogquist
openaire   +2 more sources

Epitope-Specific Tolerance Modes Differentially Specify Susceptibility to Proteolipid Protein-Induced Experimental Autoimmune Encephalomyelitis

Frontiers in Immunology, 2017
Immunization with myelin components can elicit experimental autoimmune encephalomyelitis (EAE). EAE susceptibility varies between mouse strains, depending on the antigen employed. BL/6 mice are largely resistant to EAE induction with proteolipid protein (
Lei Wang, Julia Winnewisser, Christine Federle, Gregor Jessberger, Klaus-Armin Nave, Hauke B. Werner, Bruno Kyewski, Ludger Klein, Maria Hinterberger   +8 more
doaj   +1 more source

Predicting Chronicity in Children and Adolescents With Newly Diagnosed Immune Thrombocytopenia at the Timepoint of Diagnosis Using Machine Learning‐Based Approaches

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Objectives To identify predictors of chronic ITP (cITP) and to develop a model based on several machine learning (ML) methods to estimate the individual risk of chronicity at the timepoint of diagnosis. Methods We analyzed a longitudinal cohort of 944 children enrolled in the Intercontinental Cooperative immune thrombocytopenia (ITP) Study ...
Severin Kasser, Alice Bizeul, Meera Chitlur, Hugo Donato, Jelena Roganovic, Julia E. Vogt, Thomas Kühne   +6 more
wiley   +1 more source

Murine liver allograft transplantation: Tolerance and donor cell chimerism [PDF]

, 1994
Nonarterialized orthotopic liver transplantation with no immunosuppression was performed in 13 mouse‐strain combinations. Two strain combinations with major histocompatibility complex class I and class II and minor histocompatibility complex disparity ...
Arnold, Billingham, Billingham, Billingham, Calne, Calne, Cohen, Corry, Coutinho, Dahmen, Davies, Demetris, Demetris, Garnier, Goulmy, Hoffmann, Houssaint, Jerne, Kamada, Liegeois, Liegeois, Mayumi, Monaco, Monaco, Murase, Ono, Peacock, Perelson, Qian, Rao, Russell, Russell, Starzl, Starzl, Starzl, Starzl, Starzl, Starzl, Starzl, Starzl, Steinman, Steinman, Strelein, Thomas, Wood, Zimmerman   +45 more
core   +1 more source

Genetic Polymorphisms in Exon 5 and Intron 5 and 7 of AIRE Are Associated with Rheumatoid Arthritis Risk in a Hungarian Population

Biology
Background: Rheumatoid arthritis (RA) is chronically persistent synovitis and systemic inflammation. Although multiple contributors are detected, only one is pivotal in the neonatal period: the negative selection of autoimmune naïve T-cells by the ...
Bálint Bérczi, Nóra Nusser, Iván Péter, Balázs Németh, Ágota Kulisch, Zsuzsanna Kiss, Zoltán Gyöngyi   +6 more
doaj   +1 more source

Silicon Sensors for Trackers at High-Luminosity Environment

, 2014
The planned upgrade of the LHC accelerator at CERN, namely the high luminosity (HL) phase of the LHC (HL-LHC foreseen for 2023), will result in a more intense radiation environment than the present tracking system was designed for.
Peltola, Timo
core   +1 more source

Rad54: the Swiss Army knife of homologous recombination? [PDF]

, 2006
Homologous recombination (HR) is a ubiquitous cellular pathway that mediates transfer of genetic information between homologous or near homologous (homeologous) DNA sequences. During meiosis it ensures proper chromosome segregation in the first division.
Heyer, Wolf-Dietrich, Li, Xuan, Rolfsmeier, Michael, Zhang, Xiao-Ping   +3 more
core   +2 more sources

Central tolerance and autoimmune diseases

Japanese Journal of Clinical Immunology, 2006
Central tolerance is established by the repertoire selection of immature T lymphocytes in the thymus, avoiding autoimmune responses to self-antigens. Differential ligand-TCR interactions that result in positive and negative selection initiate differential intracellular signals that, in turn, lead to the survival-or-death decision of immature thymocytes.
Takeshi, Nitta, Yousuke, Takahama
openaire   +3 more sources

Prognostic Impact of Treatment Modalities, Including Targeted Compartmental Radio‐Immunotherapy, in a Cohort of Neuroblastoma Patients With CNS Metastases at Relapse

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Introduction Neuroblastoma (NB) with central nervous system (CNS) metastases is rare at diagnosis, but occurs more often during relapse/progression. Patients with CNS metastases face a dismal prognosis, with no standardized curative treatment available.
Vicente Santa‐Maria Lopez, Anna Felip‐Badia, Marina Caballero‐Bellon, Nazaret Sanchez‐Sierra, Alicia Castañeda, Moira Garraus, Maite Gorostegui, Margarida Simão‐Rafael, Juan Pablo Muñoz, Marta Perez‐Somarriba, Salvador Mañe, Mariana Cecilia Planells, Sara Perez‐Jaume, Jaume Mora   +13 more
wiley   +1 more source

Destabilizing the autoinhibitory conformation of Zap70 induces up-regulation of inhibitory receptors and T cell unresponsiveness. [PDF]

, 2017
Zap70 plays a critical role in normal T cell development and T cell function. However, little is known about how perturbation of allosteric autoinhibitory mechanisms in Zap70 impacts T cell biology.
Chen, Yiling, Cheng, Debra A, Hsu, Lih-Yun, Liang, Hong-Erh, Weiss, Arthur   +4 more
core   +2 more sources