Results 81 to 90 of about 1,358,589 (334)

By dawn or dusk—how circadian timing rewrites bacterial infection outcomes

FEBS Letters, EarlyView.
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo, Catherine S. Palmer, Jacqueline M. Kimmey   +2 more
wiley   +1 more source

First record of dot-winged crake, Porzana spiloptera, durnford, 1877 (Rallidae) for the central Andes in Argentina [PDF]

, 2017
Porzana spiloptera, the Dot-wing Crake, has a patchy distribution in southern South America and has previously been considered as inhabiting exclusively lowland wetlands.
Cuervo Bustamante, Pablo Fernando, Llambías, Paulo E., Zarco, Agustín   +2 more
core   +1 more source

Hematopoietic (stem) cells—The elixir of life?

FEBS Letters, EarlyView.
The aging of HSCs (hematopoietic stem cells) and the blood system leads to the decline of other organs. Rejuvenating aged HSCs improves the function of the blood system, slowing the aging of the heart, kidney, brain, and liver, and the occurrence of age‐related diseases.
Emilie L. Cerezo, Jonah Anderson, Emilie Dinh Vedrenne, Noël Yeh Martín, Jette Lengefeld   +4 more
wiley   +1 more source

Ehf and Fezf2 regulate late medullary thymic epithelial cell and thymic tuft cell development

Frontiers in Immunology
Thymic epithelial cells are indispensable for T cell maturation and selection and the induction of central immune tolerance. The self-peptide repertoire expressed by medullary thymic epithelial cells is in part regulated by the transcriptional regulator ...
Sören Lammers, Victor Barrera, Philip Brennecke, Philip Brennecke, Corey Miller, Joon Yoon, Jared Balolong, Mark S. Anderson, Shannan Ho Sui, Lars M. Steinmetz, Lars M. Steinmetz, Lars M. Steinmetz, Ulrich H. von Andrian, Ulrich H. von Andrian, Kristin Rattay, Kristin Rattay   +15 more
doaj   +1 more source

MOLECULAR AND CELLULAR MECHANISMS MEDIATED BY DENDRITIC CELLS INVOLVED IN THE INDUCTION OF TOLERANCE

Медицинская иммунология, 2017
Autoimmune diseases  and  complications  after  transplantation  operations are  major   public health  problem, as they often  lead to deterioration in the quality  of life, reduce  work capacity  and  disability in the  population.
S. V. Sennikov, E. V. Kulikova, N. Yu. Knauer, Yu. N. Khantakova   +3 more
doaj   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Abdominal obesity and the prevalence of diabetes and intermediate hyperglycaemia in Chinese adults [PDF]

Objective: To assess the association of indicators of general and abdominal obesity with the prevalence of type 2 diabetes (T2DM) and intermediate hyperglycaemia (IHG) in the Chinese population.
Feskens, E.J.M., Fu, P., He, Y., Ma, G., Veer, P., van 't, Yang, X., Zhai, F., Zhang, J.   +7 more
core   +3 more sources

Peptide‐based ligand antagonists block a Vibrio cholerae adhesin

FEBS Letters, EarlyView.
The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang, Grace Du, Charity Yongo‐Luwawa, Angelina Lu, Brett Kinrade, Kim Munro, Karl E. Klose, William D. Lubell, Peter Davies, Shuaiqi Guo   +9 more
wiley   +1 more source

Evaluating in vivo approaches for studying the roles of thymic DCs in T cell development in mice

Frontiers in Immunology
T cells express an enormous repertoire of T cell receptors, enabling them to recognize any potential antigen. This large repertoire undergoes stringent selections in the thymus, where receptors that react to self- or non-danger-associated- antigens are ...
Yi Wang, Yi Wang, Mark M. W. Chong, Mark M. W. Chong   +3 more
doaj   +1 more source

Non-responder phenotype reveals apparent microbiome-wide antibiotic tolerance in the murine gut

Communications Biology, 2021
Diener, Hoge et al. show that a third of mice exhibit tolerance to a high dose of the β-lactam antibiotic cefoperazone, independent of antibiotic treatment duration or dietary phytochemical amendment.
Christian Diener, Anna C. H. Hoge, Sean M. Kearney, Ulrike Kusebauch, Sushmita Patwardhan, Robert L. Moritz, Susan E. Erdman, Sean M. Gibbons   +7 more
doaj   +1 more source