Movement Disorders, EarlyView.Abstract Background Peripheral disease mechanisms such as immune dysregulation may contribute to Parkinson's disease (PD). To investigate interactions between common PD mutations and immune responses to environmental pathogens, we studied responses to Pseudomonas aeruginosa (P.
Julian R. Mark +8 more
wiley +1 more source
SAS-4 is recruited to a dynamic structure in newly forming centrioles that is stabilized by the gamma-tubulin-mediated addition of centriolar microtubules. [PDF]
, 2008 Centrioles are surrounded by pericentriolar material (PCM), which is proposed to promote new centriole assembly by concentrating gamma-tubulin. Here, we quantitatively monitor new centriole assembly in living Caenorhabditis elegans embryos, focusing on ...
Dammermann, Alexander +3 more
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Augmin-dependent microtubule nucleation at microtubule walls in the spindle [PDF]
, 2013 © The Author(s), 2013. This article is distributed under the terms of the Creative Commons Attribution License. The definitive version was published in Journal of Cell Biology 202 (2013): 25-33, doi:10.1083/jcb.201304031.The formation of a functional ...
Goshima, Gohta +6 more
core +1 more source
Sub-centrosomal mapping identifies augmin-γTuRC as part of a centriole-stabilizing scaffold
Nature Communications, 2020 Centriole biogenesis and maintenance are crucial for cells to generate cilia and assemble centrosomes that function as microtubule organizing centers (MTOCs).
Nina Schweizer +6 more
semanticscholar +1 more source
Daughter centrioles assemble preferentially towards the nuclear envelope in Drosophila syncytial embryos [PDF]
, 2021 Neil Cunningham +2 more
openalex +1 more source
The Journal of Cell Biology, 1966 Sperm formation was studied in the fern, Marsilea, and the cycad, Zamia, with particular emphasis on the centrioles. In Marsilea, the mature sperm possesses over 100 flagella, the basal bodies of which have the typical cylindrical structure of centrioles. Earlier observations by light microscopy suggested that these centrioles arise by fragmentation of
Ikuko Mizukami, Joseph Gall
openaire +1 more source
Deuterosome-Mediated Centriole Biogenesis [PDF]
Developmental Cell, 2013 The ability of cells to faithfully duplicate their two centrioles once per cell cycle is critical for proper mitotic progression and chromosome segregation. Multiciliated cells represent an interesting variation of centriole duplication in that these cells generate greater than 100 centrioles, which form the basal bodies of their motile cilia.
Klos Dehring, Deborah A. +5 more
openaire +2 more sources
The use of deidentified organ donor testes for research
Andrology, EarlyView.Abstract Our knowledge of testis development and function mainly comes from research using mammalian model organisms, primarily the mouse. However, there are integral differences between men and other mammalian species regarding cellular composition and expression profiles during fetal and post‐natal testis development and in the mature testis ...
Marina V. Pryzhkova +4 more
wiley +1 more source
Intercellular Migration of Centrioles in the Germarium of \u3cem\u3eDrosophila melanogaster\u3c/em\u3e. An Electron Microscopic Study [PDF]
, 1970 A cluster of centrioles has been found in the early Drosophila oocyte. Since the oocyte is connected to 15 nurse cells by a system of intercellular bridges or ring canals, the possibility that the cluster of centrioles arose in the germarium from an ...
Mahowald, Anthony P. +1 more
core +1 more source
Photoreceptor Outer Segment-like Structures in Long-Term 3D Retinas from Human Pluripotent Stem Cells. [PDF]
, 2017 The retinal degenerative diseases, which together constitute a leading cause of hereditary blindness worldwide, are largely untreatable. Development of reliable methods to culture complex retinal tissues from human pluripotent stem cells (hPSCs) could ...
Angueyra, Juan M +9 more
core +1 more source