Results 101 to 110 of about 19,940 (252)
Q&A: Who needs a centrosome? [PDF]
, 2013 The centrosome has several functions. The central one is as the major microtubule organizing center (MTOC) in proliferating animal cells: thus, it helps to organize the microtubules that form the mitotic spindle in dividing cells, and orchestrate a ...
Bettencourt-Dias, Mónica
core +2 more sources
Photochemistry and Photobiology, EarlyView.Exposure to solar ultraviolet radiation is the main etiologic driver of nonmelanoma skin cancers (NMSCs), including basal cell (BCC) and cutaneous squamous cell carcinomas (cSCC), which are the most prevalent types of cancers in the US. In this study, we demonstrate that the serine/threonine kinase Polo‐like kinase 4 (PLK4) is overexpressed in NMSCs ...
Mary A. Ndiaye +5 more
wiley +1 more source
The mother centriole plays an instructive role in defining cell geometry.
PLoS Biology, 2007 Centriole positioning is a key step in establishment and propagation of cell geometry, but the mechanism of this positioning is unknown. The ability of pre-existing centrioles to induce formation of new centrioles at a defined angle relative to ...
Jessica L Feldman +2 more
doaj +1 more source
eLife, 2017 The centriole/basal body is a eukaryotic organelle that plays essential roles in cell division and signaling. Among five known core centriole proteins, SPD-2/Cep192 is the first recruited to the site of daughter centriole formation and regulates the ...
Kenji Sugioka +8 more
doaj +1 more source
Two-step phosphorylation of Ana2 by Plk4 is required for the sequential loading of Ana2 and Sas6 to initiate procentriole formation. [PDF]
, 2017 The conserved process of centriole duplication requires Plk4 kinase to recruit and promote interactions between Sas6 and Sas5/Ana2/STIL (respective nomenclature of worms/flies/humans).
Abdelaziz, Mohammed +6 more
core +2 more sources
Spaceborne and spaceborn: Physiological aspects of pregnancy and birth during interplanetary flight
Experimental Physiology, EarlyView.Abstract Crewed interplanetary return missions that are on the planning horizon will take years, more than enough time for initiation and completion of a pregnancy. Pregnancy is viewed as a sequence of processes – fertilization, blastocyst formation, implantation, gastrulation, placentation, organogenesis, gross morphogenesis, birth and neonatal ...
Arun V. Holden
wiley +1 more source
The Journal of Cell Biology, 2007 ![][1] A centriole (green) speeds away from the PCM (red) in a Cnn mutant embryo. Like a sailboat, centrioles drift away if they aren't properly moored, as Lucas and Raff show on page [725][2]. The researchers pin down a protein that helps keep the structures in place.
openaire +3 more sources
Production of Basal Bodies in bulk for dense multicilia formation [version 1; referees: 2 approved]
F1000Research, 2016 Centriole number is normally under tight control and is directly linked to ciliogenesis. In cells that use centrosomes as mitotic spindle poles, one pre-existing mother centriole is allowed to duplicate only one daughter centriole per cell cycle.
Xiumin Yan, Huijie Zhao, Xueliang Zhu
doaj +1 more source
Dynamic centriolar localization of Polo and Centrobin in early mitosis primes centrosome asymmetry.
PLoS Biology, 2020 Centrosomes, the main microtubule organizing centers (MTOCs) of metazoan cells, contain an older "mother" and a younger "daughter" centriole. Stem cells either inherit the mother or daughter-centriole-containing centrosome, providing a possible mechanism
Emmanuel Gallaud +8 more
doaj +1 more source
Genomic instability in human cancer: molecular insights and opportunities for therapeutic attack and prevention through diet and nutrition [PDF]
, 2015 Genomic instability can initiate cancer, augment progression, and influence the overall prognosis of the affected patient. Genomic instability arises from many different pathways, such as telomere damage, centrosome amplification, epigenetic ...
Amedei, Amedeo +34 more
core +1 more source