Results 101 to 110 of about 20,027 (280)
The Journal of Cell Biology, 2007 ![][1] A centriole (green) speeds away from the PCM (red) in a Cnn mutant embryo. Like a sailboat, centrioles drift away if they aren't properly moored, as Lucas and Raff show on page [725][2]. The researchers pin down a protein that helps keep the structures in place.
openaire +3 more sources
Cell Reports, 2015 In animal cells, supernumerary centrosomes, resulting from centriole amplification, cause mitotic aberrations and have been associated with diseases, including microcephaly and cancer.
Edo Dzafic +3 more
doaj +1 more source
C-Nap1 mutation affects centriole cohesion and is associated with a Seckel-like syndrome in cattle [PDF]
, 2015 Caprine-like Generalized Hypoplasia Syndrome (SHGC) is an autosomal-recessive disorder in Montbéliarde cattle. Affected animals present a wide range of clinical features that include the following: delayed development with low birth weight, hind limb ...
Barbey, Sarah +24 more
core +4 more sources
The absence of both RIBC1 and RIBC2 induces decreased sperm motility and litter size in male mice
Andrology, EarlyView.Abstract Background RIBC1 (RIB43A domain with coiled‐coils 1) and RIBC2 (RIB43A domain with coiled‐coils 2) are homolog proteins of RIB43a which is localized to microtubules in the cilia and flagella of unicellular organisms. Cryo‐electron microscopy and artificial intelligence studies showed that RIBC1 and RIBC2 are microtubule inner proteins (MIPs ...
Kento Katsuma +7 more
wiley +1 more source
Production of Basal Bodies in bulk for dense multicilia formation [version 1; referees: 2 approved]
F1000Research, 2016 Centriole number is normally under tight control and is directly linked to ciliogenesis. In cells that use centrosomes as mitotic spindle poles, one pre-existing mother centriole is allowed to duplicate only one daughter centriole per cell cycle.
Xiumin Yan, Huijie Zhao, Xueliang Zhu
doaj +1 more source
Role of Centriolar Matrix and Striated Rootlets in Centriolar Pairing and Orientation During Spermatogenesis in Hydractina echinata [PDF]
, 1985 Transmission electron microscopy of the spermatogenic stages of the hydroid, Hydractinia echinata, reveals a series of complex structural and positional changes in the centrioles of spermatocytes and spermatids.
Kleve, Maurice G.
core +2 more sources
A role for Separase in telomere protection [PDF]
, 2016 Drosophila telomeres are elongated by transposition of specialized retroelements rather than telomerase activity and are assembled independently of the sequence. Fly telomeres are protected by the terminin complex that localizes and functions exclusively
Bosso, Giuseppe +9 more
core +1 more source
Clinical Genetics, EarlyView.Missense variants in TMEM17 disrupt its localization and function at the ciliary transition zone, leading to a wide range of ciliopathy phenotypes, from OFD6 and Joubert syndromes to Meckel syndrome. ABSTRACT Ciliopathies are rare genetic disorders characterized by significant genetic and phenotypic variability.
Lucile Boutaud +19 more
wiley +1 more source
The mother centriole plays an instructive role in defining cell geometry.
PLoS Biology, 2007 Centriole positioning is a key step in establishment and propagation of cell geometry, but the mechanism of this positioning is unknown. The ability of pre-existing centrioles to induce formation of new centrioles at a defined angle relative to ...
Jessica L Feldman +2 more
doaj +1 more source
eLife, 2013 Centrioles organise centrosomes and template cilia and flagella. Several centriole and centrosome proteins have been linked to microcephaly (MCPH), a neuro-developmental disease associated with small brain size. CPAP (MCPH6) and STIL (MCPH7) are required
Matthew A Cottee +9 more
doaj +1 more source