Philosophical Transactions of the Royal Society B: Biological Sciences, 2014 Centrioles are among the largest protein-based structures found in most cell types, measuring approximately 250 nm in diameter and approximately 500 nm long in vertebrate cells. Here, we briefly review ultrastructural observations about centrioles and associated structures.
Mark Winey, Eileen O’Toole
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Centriole signaling restricts hepatocyte ploidy to maintain liver integrity [PDF]
Genes & Development, 2022 In this study, Sladky et al. investigated how the PIDDosome–TP53 pathway triggers hepatocyte polyploidization, a tightly controlled process that is initiated at weaning and increases with age.
Valentina C. Sladky +8 more
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Centriolar satellites expedite mother centriole remodeling to promote ciliogenesis
bioRxiv, 2022 Centrosomes are orbited by centriolar satellites, dynamic multiprotein assemblies nucleated by PCM1. To study the requirement for centriolar satellites, we generated mice lacking PCM1.
Emma A. Hall +18 more
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C. elegans SSNA-1 is required for the structural integrity of centrioles and bipolar spindle assembly [PDF]
Nature CommunicationsCentrioles play key roles in mitotic spindle assembly. Once assembled, centrioles exhibit long-term stability, but how stability is achieved and how it is regulated are not completely understood.
Jason A. Pfister +10 more
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Multimodal mechanisms of human centriole engagement and disengagement [PDF]
The EMBO JournalCentrioles are unique cellular structures that replicate to produce identical copies, ensuring accurate chromosome segregation during mitosis. A new centriole, the “daughter”, is assembled adjacent to an existing “mother” centriole.
Kei K Ito +9 more
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Mechanisms of HsSAS-6 assembly promoting centriole formation in human cells [PDF]
, 2014 SAS-6 proteins are thought to impart the ninefold symmetry of centrioles, but the mechanisms by which their assembly occurs within cells remain elusive. In this paper, we provide evidence that the N-terminal, coiled-coil, and C-terminal domains of HsSAS ...
Arquint +60 more
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Phase separation of Polo-like kinase 4 by autoactivation and clustering drives centriole biogenesis
Nature Communications, 2019 Tight control of centriole duplication is critical for normal chromosome segregation and the maintenance of genomic stability. Polo-like kinase 4 (Plk4) is a key regulator of centriole biogenesis.
Jung-Eun Park +2 more
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Cep63 and cep152 cooperate to ensure centriole duplication. [PDF]
PLoS ONE, 2013 Centrosomes consist of two centrioles embedded in pericentriolar material and function as the main microtubule organising centres in dividing animal cells.
Nicola J Brown +4 more
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Once and only once: mechanisms of centriole duplication and their deregulation in disease
Nature Reviews Molecular Cell Biology, 2018 Erich A Nigg, Andrew J Holland
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NR5A1 prevents centriole splitting by inhibiting centrosomal DNA-PK activation and β-catenin accumulation [PDF]
, 2014 Chia‐Yih Wang +3 more
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