Results 11 to 20 of about 20,027 (280)
Insights into centriole geometry revealed by cryotomography of doublet and triplet centrioles. [PDF]
eLife, 2018 Centrioles are cylindrical assemblies comprised of 9 singlet, doublet, or triplet microtubules, essential for the formation of motile and sensory cilia.
Agard, David A +3 more
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Current Biology, 2010 Centrioles are conserved microtubule-based organelles that lie at the core of the animal centrosome and play a crucial role in nucleating the formation of cilia and flagella in most eukaryotes. Centrioles have a complex ultrastructure with ninefold symmetry and a well-defined length.
Juliette Azimzadeh, Wallace F. Marshall
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Philosophical Transactions of the Royal Society B: Biological Sciences, 2014 Centrioles are among the largest protein-based structures found in most cell types, measuring approximately 250 nm in diameter and approximately 500 nm long in vertebrate cells. Here, we briefly review ultrastructural observations about centrioles and associated structures.
Winey, Mark, O'Toole, Eileen
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Revisiting the Role of the Mother Centriole in Centriole Biogenesis [PDF]
Science, 2007 Centrioles duplicate once in each cell division cycle through so-called templated or canonical duplication. SAK, also called PLK4 (SAK/PLK4), a kinase implicated in tumor development, is an upstream regulator of canonical biogenesis necessary for centriole formation.
Giuliano Callaini +12 more
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Molecular and Cellular Endocrinology, 2020 Centrioles are eukaryotic subcellular structures that produce and regulate massive cytoskeleton superstructures. They form centrosomes and cilia, regulate new centriole formation, anchor cilia to the cell, and regulate cilia function. These basic centriolar functions are executed in sperm cells during their amplification from spermatogonial stem cells ...
Alexa Carr +3 more
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Current Opinion in Cell Biology, 2013 Centrioles are the key foundation of centrosomes and cilia, yet a molecular understanding of how they form has only recently begun to emerge. Building a fully functional centriole that can form a centrosome and cilium requires two cell cycles. Centriole building starts with procentriole nucleation, a process that is coordinated by the conserved ...
Tomer Avidor-Reiss +1 more
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The Centriole’s Role in Miscarriages [PDF]
Frontiers in Cell and Developmental Biology, 2022 Centrioles are subcellular organelles essential for normal cell function and development; they form the cell’s centrosome (a major cytoplasmic microtubule organization center) and cilium (a sensory and motile hair-like cellular extension). Centrioles with evolutionarily conserved characteristics are found in most animal cell types but are absent in egg
Tomer Avidor-Reiss +4 more
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Centrioles without microtubules - a new morphological type of centriole [PDF]
Biology Open, 2018 The centrosome is the organizing center of microtubules in the cell, the basis for the origin of cilia and flagella and a site for the concentration of a regulatory proteins multitude. The centrosome comprises two centrioles surrounded by pericentriolar material.
Christophe Bressac +3 more
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Flies without Centrioles [PDF]
Cell, 2006 Centrioles and centrosomes have an important role in animal cell organization, but it is uncertain to what extent they are essential for animal development. The Drosophila protein DSas-4 is related to the human microcephaly protein CenpJ and the C. elegans centriolar protein Sas-4.
C. Geoffrey Woods +8 more
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Overview of the centriole architecture
Current Opinion in Structural Biology, 2021 The centriole is a magnificent molecular assembly of several giga-daltons, one of the largest of the eukaryotic cell, and whose atomic structure remains unsolved to date. However, numerous electron microscopy, cryo-tomography, and super-resolution studies now make it possible to establish a global architectural view of it with its different sub-regions.
LeGuennec, Maeva +4 more
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