Results 11 to 20 of about 19,940 (252)
Insights into centriole geometry revealed by cryotomography of doublet and triplet centrioles. [PDF]
eLife, 2018 Centrioles are cylindrical assemblies comprised of 9 singlet, doublet, or triplet microtubules, essential for the formation of motile and sensory cilia.
Agard, David A +3 more
core +7 more sources
CEP162: A critical regulator of ciliary transition zone assembly and its implications in ciliopathies. [PDF]
J Cell Commun SignalAbstract CEP162, a 162‐kDa centrosome protein, is a crucial centrosomal adapter, mediating cell differentiation and polarization. CEP162 maintains mitosis by dynamically stabilizing microtubules. CEP162 promotes the transition zone (TZ) assembly in the basal body through interaction with CEP131, CEP290, and axoneme microtubules as well as the distal ...
Yin J +7 more
europepmc +2 more sources
Current Biology, 2010 Centrioles are conserved microtubule-based organelles that lie at the core of the animal centrosome and play a crucial role in nucleating the formation of cilia and flagella in most eukaryotes. Centrioles have a complex ultrastructure with ninefold symmetry and a well-defined length.
Juliette Azimzadeh, Wallace F. Marshall
openaire +3 more sources
Philosophical Transactions of the Royal Society B: Biological Sciences, 2014 Centrioles are among the largest protein-based structures found in most cell types, measuring approximately 250 nm in diameter and approximately 500 nm long in vertebrate cells. Here, we briefly review ultrastructural observations about centrioles and associated structures.
Winey, Mark, O'Toole, Eileen
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Revisiting the Role of the Mother Centriole in Centriole Biogenesis [PDF]
Science, 2007 Centrioles duplicate once in each cell division cycle through so-called templated or canonical duplication. SAK, also called PLK4 (SAK/PLK4), a kinase implicated in tumor development, is an upstream regulator of canonical biogenesis necessary for centriole formation.
Giuliano Callaini +12 more
openaire +6 more sources
Molecular and Cellular Endocrinology, 2020 Centrioles are eukaryotic subcellular structures that produce and regulate massive cytoskeleton superstructures. They form centrosomes and cilia, regulate new centriole formation, anchor cilia to the cell, and regulate cilia function. These basic centriolar functions are executed in sperm cells during their amplification from spermatogonial stem cells ...
Alexa Carr +3 more
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Mechanical stretch scales centriole number to apical area via Piezo1 in multiciliated cells
eLife, 2021 How cells count and regulate organelle number is a fundamental question in cell biology. For example, most cells restrict centrioles to two in number and assemble one cilium; however, multiciliated cells (MCCs) synthesize hundreds of centrioles to ...
Saurabh Kulkarni +5 more
doaj +1 more source
Current Opinion in Cell Biology, 2013 Centrioles are the key foundation of centrosomes and cilia, yet a molecular understanding of how they form has only recently begun to emerge. Building a fully functional centriole that can form a centrosome and cilium requires two cell cycles. Centriole building starts with procentriole nucleation, a process that is coordinated by the conserved ...
Tomer Avidor-Reiss +1 more
openaire +3 more sources
Centrioles without microtubules - a new morphological type of centriole [PDF]
Biology Open, 2018 The centrosome is the organizing center of microtubules in the cell, the basis for the origin of cilia and flagella and a site for the concentration of a regulatory proteins multitude. The centrosome comprises two centrioles surrounded by pericentriolar material.
Christophe Bressac +3 more
openaire +4 more sources
The Centriole’s Role in Miscarriages [PDF]
Frontiers in Cell and Developmental Biology, 2022 Centrioles are subcellular organelles essential for normal cell function and development; they form the cell’s centrosome (a major cytoplasmic microtubule organization center) and cilium (a sensory and motile hair-like cellular extension). Centrioles with evolutionarily conserved characteristics are found in most animal cell types but are absent in egg
Tomer Avidor-Reiss +4 more
openaire +3 more sources