Results 71 to 80 of about 20,027 (280)

The Role of Sperm Centrioles in Human Reproduction – The Known and the Unknown

Frontiers in Cell and Developmental Biology, 2019
Each human spermatozoon contains two remodeled centrioles that it contributes to the zygote. There, the centrioles reconstitute a centrosome that assembles the sperm aster and participate in pronuclei migration and cleavage. Thus, centriole abnormalities
Tomer Avidor-Reiss, Tomer Avidor-Reiss, Matthew Mazur, Matthew Mazur, Emily L. Fishman, Puneet Sindhwani, Puneet Sindhwani   +6 more
doaj   +1 more source

Cep63 and cep152 cooperate to ensure centriole duplication. [PDF]

PLoS ONE, 2013
Centrosomes consist of two centrioles embedded in pericentriolar material and function as the main microtubule organising centres in dividing animal cells.
Nicola J Brown, Marko Marjanović, Jens Lüders, Travis H Stracker, Vincenzo Costanzo   +4 more
doaj   +1 more source

Photoreceptor Outer Segment-like Structures in Long-Term 3D Retinas from Human Pluripotent Stem Cells. [PDF]

, 2017
The retinal degenerative diseases, which together constitute a leading cause of hereditary blindness worldwide, are largely untreatable. Development of reliable methods to culture complex retinal tissues from human pluripotent stem cells (hPSCs) could ...
Angueyra, Juan M, Ball, John, Grebe, Rhonda, Jones, Bryan W, Kim, Catherine, Li, Wei, Maruotti, Julien A, Sripathi, Srinivasa R, Wahlin, Karl J, Zack, Donald J   +9 more
core   +1 more source

PLK4: Master Regulator of Centriole Duplication and Its Therapeutic Potential

Cytoskeleton, EarlyView.
ABSTRACT Centrosomes catalyze the assembly of a microtubule‐based bipolar spindle, essential for the precise chromosome segregation during cell division. At the center of this process lies Polo‐Like Kinase 4 (PLK4), the master regulator that controls the duplication of the centriolar core to ensure the correct balance of two centrosomes per dividing ...
Muhammad Hamzah, Franz Meitinger, Midori Ohta   +2 more
wiley   +1 more source

Intercellular Migration of Centrioles in the Germarium of \u3cem\u3eDrosophila melanogaster\u3c/em\u3e. An Electron Microscopic Study [PDF]

, 1970
A cluster of centrioles has been found in the early Drosophila oocyte. Since the oocyte is connected to 15 nurse cells by a system of intercellular bridges or ring canals, the possibility that the cluster of centrioles arose in the germarium from an ...
Mahowald, Anthony P., Strassheim, Joan M.   +1 more
core   +1 more source

Dissecting the Structural Organization, Recruitment and Activation Mechanisms of Centrosomal γ‐TuRCs

Cytoskeleton, EarlyView.
ABSTRACT Visualizing human centrosomes using cryo‐electron tomography revealed the native structure and molecular organization of γ‐tubulin ring complexes (γ‐TuRCs). γ‐TuRCs localized to two distinct centrosomal pools, one in the pericentriolar material (PCM) and another in the centriole lumen, which is released during mitosis.
Florian W. Hofer, Martin Würtz, Qi Gao, Bram J. A. Vermeulen, Elmar Schiebel, Stefan Pfeffer   +5 more
wiley   +1 more source

Ultrastructural description and cytochemical study of the spermatozoon of Crotallus durissus (Squamata, Serpentes) [PDF]

, 2008
The present study was undertaken to elucidate some aspects about the nature of the spermatozoon ultrastructure of Crotallus durissus using cytochemical methods.
Bastos, Leonora Tavares, Báo, Sônia Nair, Cunha, Larissa Dias   +2 more
core   +1 more source

LZTS2 Negatively Regulates Centrosomal CEP135 Levels and Microtubule Nucleation

Cytoskeleton, EarlyView.
ABSTRACT The microtubule cytoskeleton is a fundamental functional component of the cell. In vertebrate proliferating cells, centrosomes are the primary microtubule organizing center (MTOC), and their dysregulation has been linked to genomic instability and cancer.
Catarina Peneda, Joana N. Bugalhao, Marco Antonio Dias Louro, Andreia Henriques‐Soares, Monica Bettencourt‐Dias   +4 more
wiley   +1 more source

Mouse SAS-6 is required for centriole formation in embryos and integrity in embryonic stem cells

eLife
SAS-6 (SASS6) is essential for centriole formation in human cells and other organisms but its functions in the mouse are unclear. Here, we report that Sass6-mutant mouse embryos lack centrioles, activate the mitotic surveillance cell death pathway, and ...
Marta Grzonka, Hisham Bazzi
doaj   +1 more source

SAS-4 is recruited to a dynamic structure in newly forming centrioles that is stabilized by the gamma-tubulin-mediated addition of centriolar microtubules. [PDF]

, 2008
Centrioles are surrounded by pericentriolar material (PCM), which is proposed to promote new centriole assembly by concentrating gamma-tubulin. Here, we quantitatively monitor new centriole assembly in living Caenorhabditis elegans embryos, focusing on ...
Dammermann, Alexander, Desai, Arshad, Maddox, Paul S, Oegema, Karen   +3 more
core   +1 more source