Architecture of the centriole cartwheel‐containing region revealed by cryo‐electron tomography
EMBO Journal, 2020 Centrioles are evolutionarily conserved barrels of microtubule triplets that form the core of the centrosome and the base of the cilium. While the crucial role of the proximal region in centriole biogenesis has been well documented, its native ...
N. Klena +14 more
semanticscholar +1 more source
Centrioles without microtubules - a new morphological type of centriole [PDF]
Biology Open, 2018 The centrosome is the organizing center of microtubules in the cell, the basis for the origin of cilia and flagella and a site for the concentration of a regulatory proteins multitude. The centrosome comprises two centrioles surrounded by pericentriolar material.
Rustem Uzbekov +2 more
openaire +3 more sources
Asymmetric Centriole Numbers at Spindle Poles Cause Chromosome Missegregation in Cancer
Cell Reports, 2017 Chromosomal instability is a hallmark of cancer and correlates with the presence of extra centrosomes, which originate from centriole overduplication. Overduplicated centrioles lead to the formation of centriole rosettes, which mature into supernumerary ...
Marco R. Cosenza +14 more
doaj +1 more source
PLoS Genetics, 2022 Centrioles are submicron-scale, barrel-shaped organelles typically found in pairs, and play important roles in ciliogenesis and bipolar spindle assembly.
Jyoti Iyer +10 more
doaj +1 more source
A novel Cep120-dependent mechanism inhibits centriole maturation in quiescent cells [PDF]
, 2018 The two centrioles of the centrosome in quiescent cells are inherently asymmetric structures that differ in age, morphology and function. How these asymmetric properties are established and maintained during quiescence remains unknown. Here, we show that
Betleja, Ewelina +3 more
core +2 more sources
Regulation of cilia abundance in multiciliated cells
eLife, 2019 Multiciliated cells (MCC) contain hundreds of motile cilia used to propel fluid over their surface. To template these cilia, each MCC produces between 100-600 centrioles by a process termed centriole amplification.
Rashmi Nanjundappa +6 more
doaj +1 more source
The SKP1-Cullin-F-box E3 ligase βTrCP and CDK2 cooperate to control STIL abundance and centriole number [PDF]
Open Biology, 2018 Deregulation of centriole duplication has been implicated in cancer and primary microcephaly. Accordingly, it is important to understand how key centriole duplication factors are regulated.
Christian Arquint +4 more
doaj +1 more source
Polo-like kinase 4 controls centriole duplication but does not directly regulate cytokinesis. [PDF]
, 2012 Centrioles organize the centrosome, and accurate control of their number is critical for the maintenance of genomic integrity. Centrioles duplicate once per cell cycle, and duplication is coordinated by Polo-like kinase 4 (Plk4).
Bettencourt-Dias, Monica +10 more
core +4 more sources
WDR90 is a centriolar microtubule wall protein important for centriole architecture integrity
bioRxiv, 2020 Centrioles are characterized by a nine-fold arrangement of long-lived microtubule triplets that are held together by an inner protein scaffold. These structurally robust organelles experience strenuous cellular processes such as cell division or ciliary ...
Emmanuelle Steib +12 more
semanticscholar +1 more source
Role for polo-like kinase 4 in mediation of cytokinesis. [PDF]
, 2019 The mitotic protein polo-like kinase 4 (PLK4) plays a critical role in centrosome duplication for cell division. By using immunofluorescence, we confirm that PLK4 is localized to centrosomes.
Brugge, Joan S +10 more
core +2 more sources