Two-step phosphorylation of Ana2 by Plk4 is required for the sequential loading of Ana2 and Sas6 to initiate procentriole formation. [PDF]
, 2017 The conserved process of centriole duplication requires Plk4 kinase to recruit and promote interactions between Sas6 and Sas5/Ana2/STIL (respective nomenclature of worms/flies/humans).
Abdelaziz, Mohammed +6 more
core +2 more sources
Nature Communications, 2018 Centrosomes are the major microtubule organising centres of animal cells. Deregulation in their number occurs in cancer and was shown to trigger tumorigenesis in mice.
Gaëlle Marteil +18 more
semanticscholar +1 more source
NuSAP Safeguards Centriole Integrity to Mediate CEP57‐CEP152 Torus Recruitment for Proper Engagement
Advanced Science, EarlyView.This study reveals a novel role for the microtubule stabilizer NuSAP at centrioles. NuSAP depletion destabilizes the centriole's tubulin structure, causing premature disengagement, PCM defects, and mis‐localization of the CEP57‐CEP63‐CEP152 complex. By reinforcing centriole architecture, NuSAP enables early CEP57 loading and initiates a newly proposed ...
Shiyu Zhang +8 more
wiley +1 more source
Insights into centriole geometry revealed by cryotomography of doublet and triplet centrioles. [PDF]
, 2018 Centrioles are cylindrical assemblies comprised of 9 singlet, doublet, or triplet microtubules, essential for the formation of motile and sensory cilia.
Agard, David A +3 more
core +1 more source
Meier–Gorlin syndrome and Wolf–Hirschhorn syndrome: two developmental disorders highlighting the importance of efficient DNA replication for normal development and neurogenesis [PDF]
, 2013 Microcephaly represents one of the most obvious clinical manifestations of impaired neurogenesis. Defects in the DNA damage response, in DNA repair, and structural abnormalities in centrosomes, centrioles and the spindle microtubule network have all been
Abramowicz, Iga +4 more
core +1 more source
Centriole and PCM cooperatively recruit CEP192 to spindle poles to promote bipolar spindle assembly
bioRxiv, 2020 The pericentriolar material (PCM) that accumulates around the centriole expands during mitosis and nucleates microtubules. While centrosomes facilitate bipolar spindle formation, the individual functions of the centriole and PCM in mitosis remain elusive.
Takumi Chinen +10 more
semanticscholar +1 more source
Centrioles: Duplicating Precariously [PDF]
Current Biology, 2007 To assemble a mitotic spindle and accurately segregate chromosomes to progeny, a cell needs to precisely regulate its centrosome number, a feat largely accomplished through the tight control of centriole duplication. Recent work showing that the overexpression of centriolar proteins can lead to the formation of multiple centrioles in the absence of pre-
openaire +2 more sources
LZTS2 Negatively Regulates Centrosomal CEP135 Levels and Microtubule Nucleation
Cytoskeleton, EarlyView.ABSTRACT The microtubule cytoskeleton is a fundamental functional component of the cell. In vertebrate proliferating cells, centrosomes are the primary microtubule organizing center (MTOC), and their dysregulation has been linked to genomic instability and cancer.
Catarina Peneda +4 more
wiley +1 more source
Re-examining the role of Drosophila Sas-4 in centrosome assembly using two-colour-3D-SIM FRAP
eLife, 2015 Centrosomes have many important functions and comprise a ‘mother’ and ‘daughter’ centriole surrounded by pericentriolar material (PCM). The mother centriole recruits and organises the PCM and templates the formation of the daughter centriole. It has been
Paul T Conduit +4 more
doaj +1 more source
Nature Communications, 2020 Centrosomes are essential organelles with functions in microtubule organization that duplicate once per cell cycle. The first step of centrosome duplication is the daughter centriole formation followed by the pericentriolar material recruitment to this ...
E. Atorino +4 more
semanticscholar +1 more source