Results 111 to 120 of about 15,297 (219)

Ana1/CEP295 is an essential player in the centrosome maintenance program regulated by Polo kinase and the PCM

EMBO Reports
Centrioles are part of centrosomes and cilia, which are microtubule organising centres (MTOC) with diverse functions. Despite their stability, centrioles can disappear during differentiation, such as in oocytes, but little is known about the regulation ...
Ana Pimenta-Marques, Tania Perestrelo, Patricia Reis-Rodrigues, Paulo Duarte, Ana Ferreira-Silva, Mariana Lince-Faria, Mónica Bettencourt-Dias   +6 more
doaj   +1 more source

Centriole triplet microtubules are required for stable centriole formation and inheritance in human cells

eLife, 2017
Centrioles are composed of long-lived microtubules arranged in nine triplets. However, the contribution of triplet microtubules to mammalian centriole formation and stability is unknown.
Jennifer T Wang, Dong Kong, Christian R Hoerner, Jadranka Loncarek, Tim Stearns   +4 more
doaj   +1 more source

Meier–Gorlin syndrome and Wolf–Hirschhorn syndrome: two developmental disorders highlighting the importance of efficient DNA replication for normal development and neurogenesis [PDF]

, 2013
Microcephaly represents one of the most obvious clinical manifestations of impaired neurogenesis. Defects in the DNA damage response, in DNA repair, and structural abnormalities in centrosomes, centrioles and the spindle microtubule network have all been
Abramowicz, Iga, Carpenter, Gillian, Colnaghi, Rita, Kerzendorfer, Claudia, O'Driscoll, Mark   +4 more
core   +1 more source

An ensemble of specifically targeted proteins stabilizes cortical microtubules in the human parasite Toxoplasma gondii [PDF]

, 2016
Although all microtubules within a single cell are polymerized from virtually identical subunits, different microtubule populations carry out specialized and diverse functions, including directional transport, force generation, and cellular morphogenesis.
Benmerzouga, Imaan, He, Yudou, Hu, Ke, Liu, Jun, Morrissette, Naomi S., Murray, John M., Sullivan, William J.   +6 more
core   +1 more source

Roles of centrioles in neural attraction of dental pulp stem cells

Journal of the Formosan Medical Association
Background/Purpose: Human nerve development is vital, affecting trauma recovery and dental issues. Early embryonic clues link nerves to tooth development via factors like Wnt and Hedgehog pathways.
Shan-Li Pei, Rung-Shu Chen, Min-Huey Chen   +2 more
doaj   +1 more source

Cep295 is a conserved scaffold protein required for generation of a bona fide mother centriole

Nature Communications, 2016
Newly formed centrioles mature into functional mother centrioles. Here the authors show that the scaffolding protein Cep295 is recruited to the procentriole assembly site and assists daughter centriole assembly and daughter-to-mother centriole conversion.
Yuki Tsuchiya, Satoko Yoshiba, Akshari Gupta, Koki Watanabe, Daiju Kitagawa   +4 more
doaj   +1 more source

Mechanisms of HsSAS-6 assembly promoting centriole formation in human cells [PDF]

, 2014
SAS-6 proteins are thought to impart the ninefold symmetry of centrioles, but the mechanisms by which their assembly occurs within cells remain elusive. In this paper, we provide evidence that the N-terminal, coiled-coil, and C-terminal domains of HsSAS ...
Arquint, Azimzadeh, Azimzadeh, Beck, Bettencourt-Dias, Bornens, Bulseco, Carvalho-Santos, Cavalier-Smith, Chen, Chrétien, Cizmecioglu, Debora Keller, Dickson, Dippell, Dzhindzhev, Gopalakrishnan, Guichard, Guichard, Gönczy, Hatch, Haupts, Hoh, Jan Ellenberg, Kim, Kitagawa, Kleylein-Sohn, Kuriyama, Lau, Lawo, Leidel, Lettman, Lin, Lukinavičius, Maeder, Malte Wachsmuth, Marshall, Mennella, Meritxell Orpinell, Middendorp, Nakazawa, Nicolas Olivier, Nigg, Olivier, Olivier, Pierre Gönczy, Puklowski, Robert Mahen, Romain Wyss, Schmidt, Sonnen, Stevens, Strnad, Strnad, Strnad, Suliana Manley, van Breugel, Virginie Hachet, Vladar, Vulprecht, Wachsmuth   +60 more
core   +3 more sources

Male gametogenesis without centrioles

Developmental Biology, 2011
The orientation of the mitotic spindle plays a central role in specifying stem cell-renewal by enabling interaction of the daughter cells with external cues: the daughter cell closest to the hub region is instructed to self-renew, whereas the distal one starts to differentiate.
Riparbelli, Maria Giovanna, Callaini, Giuliano   +1 more
openaire   +3 more sources

The basal bodies of Chlamydomonas reinhardtii [PDF]

, 2016
The unicellular green alga, Chlamydomonas reinhardtii, is a biflagellated cell that can swim or glide. C. reinhardtii cells are amenable to genetic, biochemical, proteomic, and microscopic analysis of its basal bodies.
Dutcher, Susan, O\u27Toole, Eileen T
core   +2 more sources

Ultrastructure of the Spermiogenesis in Halyomorpha halys (Hemiptera: Pentatomidae): X-Irradiation and New Insights on the Centriolar Region Organization

Insects
Halyomorpha halys (Heteroptera: Pentatomidae) is an insect pest native to Asia that has spread over the last two decades to most of the North America, parts of South America, Europe and North Africa.
Francesco Paoli, Massimo Cristofaro, Gerardo Roselli, Raffaele Sasso, Sergio Musmeci, Francesco Barbieri, Chiara Sciandra, Valentina Vanoni, Loris Menegotti, Pio Federico Roversi, Gianfranco Anfora, David Mercati, Romano Dallai   +12 more
doaj   +1 more source