Results 61 to 70 of about 15,297 (219)

SAS-4 is recruited to a dynamic structure in newly forming centrioles that is stabilized by the gamma-tubulin-mediated addition of centriolar microtubules. [PDF]

, 2008
Centrioles are surrounded by pericentriolar material (PCM), which is proposed to promote new centriole assembly by concentrating gamma-tubulin. Here, we quantitatively monitor new centriole assembly in living Caenorhabditis elegans embryos, focusing on ...
Dammermann, Alexander, Desai, Arshad, Maddox, Paul S, Oegema, Karen   +3 more
core   +1 more source

C-Nap1 mutation affects centriole cohesion and is associated with a Seckel-like syndrome in cattle [PDF]

, 2015
Caprine-like Generalized Hypoplasia Syndrome (SHGC) is an autosomal-recessive disorder in Montbéliarde cattle. Affected animals present a wide range of clinical features that include the following: delayed development with low birth weight, hind limb ...
Barbey, Sarah, Bertaud, Maud, Boichard, Didier, Bourgain-Guglielmetti, Florence, Cesbron, Nora, Cormier-Daire, Valérie, Duchesne, Amandine, E L Hokayem, Joyce, Eggen, Andre, Floriot, Sandrine, Fritz, Sebastien, Gautier, Mathieu, Guatteo, Raphaël, Halliez, Sophie, Karaiskou, Anthi, Manciaux, Luc, Moudjou, Mohammed, Nigg, Erich A, Rodriguez, Sabrina, Schibler, Laurent, Schneider-Maunoury, Sylvie, Sobczak-Thépot, Joelle, Toutirais, Geraldine, Vasilescu, Alexandre, Vesque, Christine   +24 more
core   +4 more sources

Centrioles: Duplicating Precariously [PDF]

Current Biology, 2007
To assemble a mitotic spindle and accurately segregate chromosomes to progeny, a cell needs to precisely regulate its centrosome number, a feat largely accomplished through the tight control of centriole duplication. Recent work showing that the overexpression of centriolar proteins can lead to the formation of multiple centrioles in the absence of pre-
openaire   +2 more sources

Unveiling a New Link: Cholesterol Deficiency in Smith–Lemli–Opitz and Niemann–Pick C as a Driver of Ciliopathies

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT The ciliopathies are a group of genetic disorders caused by defective function of either the primary cilia (a large number) or the motile cilia (a much smaller number). These have been defined as diseases with mutations in genes encoding individual ciliary or cilia‐associated proteins.
Robert P. Erickson, Maria Teresa Fiorenza   +1 more
wiley   +1 more source

Centriole polarisation to the immunological synapse directs secretion from cytolytic cells of both the innate and adaptive immune systems [PDF]

, 2011
BACKGROUND: Cytolytic cells of the immune system destroy pathogen-infected cells by polarised exocytosis of secretory lysosomes containing the pore-forming protein perforin.
Daniela Pende, Gillian M Griffiths, Jane C Stinchcombe, Mariolina Salio, Maurizo Arico, Vincenzo Cerundolo   +5 more
core   +3 more sources

Revisiting the Role of the Mother Centriole in Centriole Biogenesis [PDF]

Science, 2007
Centrioles duplicate once in each cell division cycle through so-called templated or canonical duplication. SAK, also called PLK4 (SAK/PLK4), a kinase implicated in tumor development, is an upstream regulator of canonical biogenesis necessary for centriole formation.
Rodrigues Martins, A., Riparbelli, M. G., Callaini, G., Glover, D. M., Bettencourt, D.   +4 more
openaire   +4 more sources

Recombinant Monoclonal Antibodies for Detecting the Tubulin Post‐Translational Modifications Glutamylation and Lysine‐40 Acetylation

Cytoskeleton, EarlyView.
ABSTRACT Post‐translational modifications (PTMs) to tubulin subunits in microtubule filaments are thought to comprise a component of the tubulin code that specifies microtubule functions in cell physiology and animal development. Acetylation of Lysine‐40 (K40) on α‐tubulin (αTub‐K40ac) and glutamylation of both α‐ and β‐tubulin are two tubulin PTMs of ...
Lynne Blasius, Ezekiel C. Thomas, Erik H. Collet, Erin Jenson, Chad G. Pearson, Ryoma Ohi, Kristen J. Verhey   +6 more
wiley   +1 more source

Maternal inheritance of functional centrioles in two parthenogenetic nematodes

Nature Communications
Centrioles are the core constituent of centrosomes, microtubule-organizing centers involved in directing mitotic spindle assembly and chromosome segregation in animal cells.
Aurélien Perrier, Nadège Guiglielmoni, Delphine Naquin, Kevin Gorrichon, Claude Thermes, Sonia Lameiras, Alexander Dammermann, Philipp H. Schiffer, Maia Brunstein, Julie C. Canman, Julien Dumont   +10 more
doaj   +1 more source

Titin Is Present in the Elastic Tethers That Connect Separating Anaphase Chromosomes in Crane‐Fly Spermatocytes

Cytoskeleton, EarlyView.
ABSTRACT Elastic tethers connect telomeres of separating chromosomes in anaphase of animal cells. Immunofluorescence staining of titin in crane‐fly spermatocytes, using 4 different antibodies, shows that the giant elastic protein titin seems to be a component of mitotic tethers: titin “strands” extend between separating chromosomes, connecting their ...
Demetra Economopoulos, Maral Janan, Martina Krüger, Aavo‐Valdur Mikelsaar, Arthur Forer, Rose Sheykhani   +5 more
wiley   +1 more source

Intercellular Migration of Centrioles in the Germarium of \u3cem\u3eDrosophila melanogaster\u3c/em\u3e. An Electron Microscopic Study [PDF]

, 1970
A cluster of centrioles has been found in the early Drosophila oocyte. Since the oocyte is connected to 15 nurse cells by a system of intercellular bridges or ring canals, the possibility that the cluster of centrioles arose in the germarium from an ...
Mahowald, Anthony P., Strassheim, Joan M.   +1 more
core   +1 more source