Results 91 to 100 of about 74,831 (235)
APC/CFZR-1 regulates centrosomal ZYG-1 to limit centrosome number [PDF]
, 2021 Jeffrey C. Medley +5 more
openalex +1 more source
Advanced Science, Volume 13, Issue 4, 19 January 2026.Brillouin‐Raman Microspectroscopy on‐a‐Chip (BRmS) enables real‐time analysis of breast tumor spheroids in microfluidic channels. Following cyclical deformations, MCF10.DCIS.com spheroids are captured in recovery traps and imaged with BRmS. The applied deformations trigger a stiffening response marked by increased frequency shifts, elevation of the ...
Mona Makkieh +22 more
wiley +1 more source
Mitochondrial Adaptation to Mechanical Stress in Cardiac Ageing and Disease
Advanced Science, Volume 13, Issue 4, 19 January 2026.Mechanical forces shape the heart's energy factories. This review explores how mitochondria in cardiac cells sense and respond to biomechanical stress, altering their structure, positioning, and metabolism. By linking mechanical cues to mitochondrial adaptation, the article highlights pathways driving heart disease and points to new strategies for ...
Aishwarya Prakash, Thomas Iskratsch
wiley +1 more source
Supernumerary Centrosomes Nucleate Extra Cilia and Compromise Primary Cilium Signaling [PDF]
, 2012 Moe R. Mahjoub, Tim Stearns
openalex +1 more source
Where, When, and How? Integrating Spatiotemporal Cues in Cell Division
BioEssays, Volume 48, Issue 1, January 2026.Accurate chromosome segregation during mitosis depends on the spatial and temporal regulation of spindle assembly, kinetochore‐microtubule attachment, and checkpoint signaling. Here, we highlight how mitotic chromosomes can serve as dynamic hubs that integrate molecular cues to coordinate spindle organization and timing, ensuring faithful genome ...
Luca Cirillo +3 more
wiley +1 more source
The NLS3 Motif in TPX2 Regulates Spindle Architecture in Xenopus Egg Extracts
Cytoskeleton, Volume 83, Issue 1, Page 29-39, January 2026.ABSTRACT A bipolar spindle composed of microtubules and many associated proteins functions to segregate chromosomes during cell division in all eukaryotes, yet both spindle size and architecture vary dramatically across different species and cell types.
Guadalupe E. Pena +4 more
wiley +1 more source
Dissecting the Structural Organization, Recruitment and Activation Mechanisms of Centrosomal γ‐TuRCs
Cytoskeleton, Volume 83, Issue 1, Page 53-56, January 2026.ABSTRACT Visualizing human centrosomes using cryo‐electron tomography revealed the native structure and molecular organization of γ‐tubulin ring complexes (γ‐TuRCs). γ‐TuRCs localized to two distinct centrosomal pools, one in the pericentriolar material (PCM) and another in the centriole lumen, which is released during mitosis.
Florian W. Hofer +5 more
wiley +1 more source
A Role for Centrin 3 in Centrosome Reproduction [PDF]
, 2000 Sandrine Middendorp +7 more
openalex +1 more source
Molecular Glues Stabilize Water‐Mediated Hydrogen Bonds in Ternary Complexes
ChemPhysChem, Volume 27, Issue 2, January 2026.The molecular glues modulate the pattern and stability of water‐mediated hydrogen bonds between the proteins of ternary complexes. By stabilizing weak and transient protein–protein interactions (PPIs), molecular glues address the challenge of targeting proteins previously considered undruggable.
Apoorva Mathur +4 more
wiley +1 more source
Microtubule nucleation and γTuRC centrosome localization in interphase cells require ch-TOG [PDF]
, 2023 Aamir Ali +3 more
openalex +1 more source