Results 101 to 110 of about 74,831 (235)

Synthetic lethality in cancer therapy: Mechanisms, models and clinical translation for overcoming therapeutic resistance

Clinical and Translational Medicine, Volume 16, Issue 1, January 2026.
Application of synthetic lethality screening in drug resistance models. Abstract Background and Rationale Synthetic lethality (SL)‐based strategies hold significant promise for overcoming therapeutic resistance, a critical bottleneck in cancer treatment where cancer cells evade anticancer therapies, leading to diminished efficacy or treatment failure ...
Junyan Li, Liyuan Zhang, Yan Shang, Juan Liu, Hailong Zhao   +4 more
wiley   +1 more source

A Role for RIC-8 (Synembryn) and GOA-1 (Goα) in Regulating a Subset of Centrosome Movements During Early Embryogenesis in Caenorhabditis elegans [PDF]

, 2000
Kenneth G. Miller, James B. Rand
openalex   +1 more source

The phosphorylation and dephosphorylation switch of VCP/p97 regulates the architecture of centrosome and spindle [PDF]

, 2022
Kaiyuan Zhu, Yang Cai, Xiaotong Si, Zuodong Ye, Yuanzhu Gao, Chuang Liu, Rui Wang, Zhibin Ma, Huazhang Zhu, Liang Zhang, Shengjin Li, Hongmin Zhang, Jianbo Yue   +12 more
openalex   +1 more source

Mapping protein–protein interactions by mass spectrometry

Mass Spectrometry Reviews, Volume 45, Issue 1, Page 69-106, January/February 2026.
Abstract Protein–protein interactions (PPIs) are essential for numerous biological activities, including signal transduction, transcription control, and metabolism. They play a pivotal role in the organization and function of the proteome, and their perturbation is associated with various diseases, such as cancer, neurodegeneration, and infectious ...
Xiaonan Liu, Lawrence Abad, Lopamudra Chatterjee, Ileana M. Cristea, Markku Varjosalo   +4 more
wiley   +1 more source

RNAi‐mediated gene silencing of a 26S proteasome subunit increases mortality of the Japanese beetle Popillia japonica

Pest Management Science, Volume 82, Issue 1, Page 1066-1078, January 2026.
We propose the regulatory particle non‐ATPase subunit 6 of the 26S proteasome as a first good promising RNA interference target candidate to control the Japanese beetle Popillia japonica. This will help to optimize a double‐stranded RNA insecticide against this priority pest with low off‐target effects on pollinators on a gene sequence‐based prediction.
Giulia Lucetti, Simona Abbà, Gabriele Pesavento, Elena Fanelli, Francesca De Luca, Elia Battagini, Stefano Cazzaniga, Matteo Ballottari, Diletta Frizzon, Nicola Mori, Luciana Galetto   +10 more
wiley   +1 more source

Asymmetry in centrosome maturation revealed through AIR-1 dynamics in the early Caenorhabditis elegans embryo

Scientific Reports
Centrosomes are critical organelles associated with the nucleus, consisting of a pair of centrioles surrounded by a cloud of pericentriolar material. They serve as key nucleation sites for microtubule arrays and are essential for positioning the nucleus ...
Shayne M. Plourde, Natalia Kravtsova, Adriana T. Dawes   +2 more
doaj   +1 more source

Centrosome amplification promotes cell invasion via cell–cell contact disruption and Rap-1 activation [PDF]

, 2023
Anu Prakash, Shishir Paunikar, Mark Webber, Emma McDermott, Sri HariKrishna Vellanki, Kerry Thompson, Peter Dockery, Hanne Jahns, James A. L. Brown, Ann M. Hopkins, Emer Bourke   +10 more
openalex   +1 more source

Multiwalled Carbon Nanotubes as Physical Drivers of Chromosome Instability and Inflammatory Responses

Small Structures, Volume 7, Issue 1, January 2026.
This article highlights the fibrous morphology of multiwalled carbon nanotubes as a key factor in their genotoxicity. Fibers physically interfere in cell division, generating binucleated cells and micronuclei, both of which are precursors of carcinogenesis.
Núria Pulido‐Artola, Joan Repullés, Marina Rodriguez‐Muñoz, Teresa Anglada, Anna Genescà   +4 more
wiley   +1 more source

Centrosomes Isolated from Spisula solidissima Oocytes Contain Rings and an Unusual Stoichiometric Ratio of α/β Tubulin [PDF]

, 1997
Jacalyn M. Vogel, Tim Stearns, Conly L. Rieder, Robert E. Palazzo   +3 more
openalex   +1 more source

The Proinflammatory Secretome of Senescent Cells Can Be Controlled by a HIF2A‐Dependent Upregulation and a FURIN‐Dependent Cleavage of the ANGPTL4 Secreted Factor

Aging Cell, Volume 25, Issue 1, January 2026.
This article supports that ANGPTL4 secreted factor is induced transcriptionally and activated by proteolytic cleavage during senescence, contributing to the production of a pro‐inflammatory SASP. In the senescent cell microenvironment, ANGPTL4 could thus contribute to senescence‐dependent alterations such as inflammation and tumor initiation.
Gabriela Makulyte, Hasan Safwan‐Zaiter, Delphine Goehrig, Anda Huna, Adèle Mangelinck, Takumi Mikawa, Alberta Palazzo, Lyvia Moudombi, Jean‐Jacques Medard, Marie Chanal, Pacôme Lecot, Marie‐Cécile Michallet, Julie Gavard, Serge Adnot, Pierre Dubus, Hiroshi Kondoh, Carl Mann, Nguan Soon Tan, Philippe Bertolino, Jean‐Michel Flaman, David Bernard   +20 more
wiley   +1 more source