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Centrosome Remodelling in Evolution [PDF]
Cells, 2018 The centrosome is the major microtubule organizing centre (MTOC) in animal cells. The canonical centrosome is composed of two centrioles surrounded by a pericentriolar matrix (PCM).
D. Ito, M. Bettencourt-Dias
semanticscholar +4 more sources
Actin nucleation at the centrosome controls lymphocyte polarity
Nature Communications, 2016 Cell polarity is marked by re-orientation of the centrosome, but the mechanisms governing centrosome polarization are poorly understood. Here Obino et al.
Dorian Obino +12 more
doaj +2 more sources
A CEP215-HSET complex links centrosomes with spindle poles and drives centrosome clustering in cancer. [PDF]
Nature Communications, 2016 Numerical centrosome aberrations underlie certain developmental abnormalities and may promote cancer. A cell maintains normal centrosome numbers by coupling centrosome duplication with segregation, which is achieved through sustained association of each ...
Barr, Alexis R +8 more
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Centrosome amplification induces high grade features and is prognostic of worse outcomes in breast cancer [PDF]
BMC Cancer, 2016 Table S1. Patient characteristics. Table S2. Hazard ratios from multivariate analysis. Table S3. Sequences of primers used for qRT-PCR. Figure S1. Distribution of average centrosome number per cell in the breast cancer patients represented in our TMA ...
Beth A. Weaver +5 more
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The centrosome and cell proliferation
Cell Division, 2006 Centrosomes are frequently amplified in cancer cells. Increased numbers of centrosomes can give rise to multipolar spindles in mitosis, and thereby lead to the formation of aneuploid daughter cells. However, whether centrosome amplification is a cause or
Merdes Andreas, Srsen Vlastimil
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The Dictyostelium Centrosome [PDF]
Cells, 2021 The centrosome of Dictyostelium amoebae contains no centrioles and consists of a cylindrical layered core structure surrounded by a corona harboring microtubule-nucleating γ-tubulin complexes. It is the major centrosomal model beyond animals and yeasts.
Ralph Gräf +4 more
openaire +4 more sources
Nature Communications, 2021 Drug resistance and tumor recurrence are major challenges in cancer treatment. Cancer cells often display centrosome amplification. To maintain survival, cancer cells achieve bipolar division by clustering supernumerary centrosomes.
Guangjian Fan +16 more
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Centrosome anchoring regulates progenitor properties and cortical formation
Nature, 2020 Radial glial progenitor cells (RGPs) are the major neural progenitor cells that generate neurons and glia in the developing mammalian cerebral cortex 1 – 4 .
W. Shao +11 more
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Centrosomal and Non-centrosomal Functions Emerged through Eliminating Centrosomes
Cell Structure and Function, 2020 Centrosomes are highly conserved organelles that act as the major microtubule-organizing center (MTOC) in animal somatic cells. Through their MTOC activity, centrosomes play various roles throughout the cell cycle, such as supporting cell migration in interphase and spindle organization and positioning in mitosis.
Takumi Chinen +3 more
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EMBO Journal, 2020 Centriole copy number is tightly maintained by the once‐per‐cycle duplication of these organelles. Centrioles constitute the core of centrosomes, which organize the microtubule cytoskeleton and form the poles of the mitotic spindle.
Lauren T. Evans +5 more
semanticscholar +1 more source