Results 11 to 20 of about 97,305 (209)
The centrosome and cell proliferation [PDF]
Cell Division, 2006 Centrosomes are frequently amplified in cancer cells. Increased numbers of centrosomes can give rise to multipolar spindles in mitosis, and thereby lead to the formation of aneuploid daughter cells. However, whether centrosome amplification is a cause or
Merdes Andreas, Srsen Vlastimil
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Site-specific phosphorylation of ZYG-1 regulates ZYG-1 stability and centrosome number
iScience, 2023 Summary: Spindle bipolarity is critical for genomic integrity. As centrosome number often dictates bipolarity, tight control of centrosome assembly is vital for faithful cell division.
Jeffrey C. Medley +8 more
doaj +1 more source
Scientific Reports, 2023 Primary cilia are key regulators of embryo development and tissue homeostasis. However, their mechanisms and functions, particularly in the context of human cells, are still unclear.
Lucia Binó, Lukáš Čajánek
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Centrosomal JAK2 Tyrosine Kinase Regulates Primary Cilia Length, Cell Proliferation, and Cilia Orientation During Cell Migration. [PDF]
FASEB JGrowth hormone (GH) activates GHR at the primary cilium and stimulates centrosomal JAK2. JAK2 centrosomal localization requires both its SH2 domain and kinase activity. Cells expressing JAK2 variants deficient in centrosomal targeting show impaired control of cilia length, reduced proliferation, and cell migration compared with parental and JAK2 WT ...
Karki G +7 more
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A catalog of numerical centrosome defects in epithelial ovarian cancers
EMBO Molecular Medicine, 2022 Centrosome amplification, the presence of more than two centrosomes in a cell is a common feature of most human cancer cell lines. However, little is known about centrosome numbers in human cancers and whether amplification or other numerical aberrations
Jean‐Philippe Morretton +25 more
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Centrosome-phagy: implications for human diseases
Cell & Bioscience, 2021 Autophagy is a prominent mechanism to preserve homeostasis and the response to intracellular or extracellular stress. Autophagic degradation can be selectively targeted to dysfunctional subcellular compartments.
Qi Wu +4 more
doaj +1 more source
iScience, 2023 Summary: Centrosomal protein 120 (CEP120) is a 120 kDa centrosome protein that plays an important role in centrosome replication. Overexpression of CEP120 can lead to centrosome duplicate abnormality, which is closely associated with tumorigenesis and ...
Chenggang Zhang +11 more
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Centrosome-kinase fusions promote oncogenic signaling and disrupt centrosome function in myeloproliferative neoplasms. [PDF]
PLoS ONE, 2014 Chromosomal translocations observed in myeloproliferative neoplasms (MPNs) frequently fuse genes that encode centrosome proteins and tyrosine kinases. This causes constitutive activation of the kinase resulting in aberrant, proliferative signaling.
Joanna Y Lee +3 more
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Cells, 2022 The Golgi complex of mammalian cells is organized in a ribbon-like structure often closely associated with the centrosome during interphase. Conversely, the Golgi complex assumes a fragmented and dispersed configuration away from the centrosome during ...
Fabiola Mascanzoni +2 more
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The phosphorylation of PHF5A by TrkA-ERK1/2-ABL1 cascade regulates centrosome separation
Cell Death and Disease, 2023 During interphase, the newly duplicated pairs of centrosomes are held together by a centrosome linker, and the centrosome separation needs the disruption of this linker to induce the duplicated centrosomes separating into two distinct microtubule ...
Chen Song +10 more
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