Results 11 to 20 of about 74,831 (235)

The Dictyostelium Centrosome [PDF]

Cells, 2021
The centrosome of Dictyostelium amoebae contains no centrioles and consists of a cylindrical layered core structure surrounded by a corona harboring microtubule-nucleating γ-tubulin complexes. It is the major centrosomal model beyond animals and yeasts.
Ralph Gräf, Marianne Grafe, Irene Meyer, Kristina Mitic, Valentin Pitzen   +4 more
openaire   +3 more sources

Centrosomal and Non-centrosomal Functions Emerged through Eliminating Centrosomes

Cell Structure and Function, 2020
Centrosomes are highly conserved organelles that act as the major microtubule-organizing center (MTOC) in animal somatic cells. Through their MTOC activity, centrosomes play various roles throughout the cell cycle, such as supporting cell migration in interphase and spindle organization and positioning in mitosis.
Takeda, Yutaka, Kuroki, Kanako, Chinen, Takumi, Kitagawa, Daiju   +3 more
openaire   +3 more sources

Centrosome Biology: Polymer-Based Centrosome Maturation [PDF]

Current Biology, 2017
The molecular mechanisms that control how the centrosome increases in size and microtubule nucleation capacity during mitosis have remained elusive. Recent work using in vitro assays provide exciting clues as to how this may occur.
Gagan D, Gupta, Laurence, Pelletier
openaire   +2 more sources

Centrosome-Associated NDR Kinase Regulates Centrosome Duplication [PDF]

Molecular Cell, 2007
Human NDR kinases are upregulated in some cancer types, yet their functions still remain undefined. Here, we report the first known function of a mammalian NDR kinase by demonstrating that human NDR directly contributes to centrosome duplication. A subpopulation of endogenous NDR localizes to centrosomes in a cell-cycle-dependent manner. Overexpression
Hergovich, Alexander, Lamla, Stefan, Nigg, Erich A., Hemmings, Brian A.   +3 more
openaire   +3 more sources

Lysine demethylase 4A: from chromatin to centrosomes. [PDF]

FEBS J
The lysine demethylase 4A (KDM4A) remodels chromatin by histone demethylation, regulating gene expression. In this issue, Chowdhury et al. report a previously undescribed localisation for KDM4A outside the nucleus, at the pericentriolar material around the centrosome.
Sharma A, Kearney RM, Morrison CG.
europepmc   +2 more sources

Cep295 is a conserved scaffold protein required for generation of a bona fide mother centriole

Nature Communications, 2016
Newly formed centrioles mature into functional mother centrioles. Here the authors show that the scaffolding protein Cep295 is recruited to the procentriole assembly site and assists daughter centriole assembly and daughter-to-mother centriole conversion.
Yuki Tsuchiya, Satoko Yoshiba, Akshari Gupta, Koki Watanabe, Daiju Kitagawa   +4 more
doaj   +1 more source

Bimodal Binding of STIL to Plk4 Controls Proper Centriole Copy Number

Cell Reports, 2018
Summary: The number of centrioles is tightly controlled to ensure bipolar spindle assembly, which is a prerequisite to maintain genome integrity. However, our understanding of the fundamental principle that governs the formation of a single procentriole ...
Midori Ohta, Koki Watanabe, Tomoko Ashikawa, Yuka Nozaki, Satoko Yoshiba, Akatsuki Kimura, Daiju Kitagawa   +6 more
doaj   +1 more source

The Cep57-pericentrin module organizes PCM expansion and centriole engagement

Nature Communications, 2019
Centriole disengagement occurs towards mitotic exit and involves cleavage of pericentrin, a component of the pericentriolar material. Here the authors show that depletion of the centrosomal protein Cep57 leads to precocious centriole disengagement, and ...
Koki Watanabe, Daisuke Takao, Kei K Ito, Mikiko Takahashi, Daiju Kitagawa   +4 more
doaj   +1 more source

IFT proteins spatially control the geometry of cleavage furrow ingression and lumen positioning

Nature Communications, 2017
Cytokinesis relies on central spindle organization and provides a spatial landmark for lumen formation. Here, the authors show that intraflagellar transport proteins are required for the localization of the cytokinetic regulator Aurora B and subsequent ...
Nicolas Taulet, Benjamin Vitre, Christelle Anguille, Audrey Douanier, Murielle Rocancourt, Michael Taschner, Esben Lorentzen, Arnaud Echard, Benedicte Delaval   +8 more
doaj   +1 more source

Centrosome loss or amplification does not dramatically perturb global gene expression in Drosophila

Biology Open, 2012
Summary Centrosome defects are a common feature of many cancers, and they can predispose fly brain cells to form tumours. In flies, centrosome defects perturb the asymmetric division of the neural stem cells, but it is unclear how this might lead to ...
Janina Baumbach, Mitchell P. Levesque, Jordan W. Raff   +2 more
doaj   +1 more source