Results 11 to 20 of about 17,279 (253)
Beyond the GTP‐cap: Elucidating the molecular mechanisms of microtubule catastrophe
BioEssays, Volume 45, Issue 1, January 2023., 2023 Microtubule dynamics are essential for myriad cellular processes. The switching between microtubule growth and shrinkage is traditionally explained by the loss of a protective “cap” of GTP‐bound tubulin subunits from the growing microtubule end. New research shows that features beyond the nucleotide content at the growing end impact microtubule ...
Veronica J. Farmer, Marija Zanic
wiley +1 more source
Dynein localization and pronuclear movement in the C. elegans zygote
Cytoskeleton, Volume 79, Issue 12, Page 133-143, December 2022., 2022 Abstract Centrosomes serve as a site for microtubule nucleation and these microtubules will grow and interact with the motor protein dynein at the cortex. The position of the centrosomes determines where the mitotic spindle will develop across all cell types.
David P. Ignacio +4 more
wiley +1 more source
Choreography of the centrosome [PDF]
Heliyon, 2020 More than a century ago, the centrosome was discovered and described as "the true division organ of the cell". Electron microscopy revealed that a centrosome is an amorphous structure or pericentriolar protein matrix that surrounds a pair of well-organized centrioles.
openaire +4 more sources
Centrosome-kinase fusions promote oncogenic signaling and disrupt centrosome function in myeloproliferative neoplasms. [PDF]
PLoS ONE, 2014 Chromosomal translocations observed in myeloproliferative neoplasms (MPNs) frequently fuse genes that encode centrosome proteins and tyrosine kinases. This causes constitutive activation of the kinase resulting in aberrant, proliferative signaling.
Joanna Y Lee +3 more
doaj +1 more source
Centriolar distal appendages activate the centrosome‐PIDDosome‐p53 signalling axis via ANKRD26
EMBO Journal, 2020 Centrosome amplification results into genetic instability and predisposes cells to neoplastic transformation. Supernumerary centrosomes trigger p53 stabilization dependent on the PIDDosome (a multiprotein complex composed by PIDD1, RAIDD and Caspase‐2 ...
Matteo Burigotto +11 more
semanticscholar +1 more source
Cells, 2022 The Golgi complex of mammalian cells is organized in a ribbon-like structure often closely associated with the centrosome during interphase. Conversely, the Golgi complex assumes a fragmented and dispersed configuration away from the centrosome during ...
Fabiola Mascanzoni +2 more
doaj +1 more source
EMBO Journal, 2020 Centriole copy number is tightly maintained by the once‐per‐cycle duplication of these organelles. Centrioles constitute the core of centrosomes, which organize the microtubule cytoskeleton and form the poles of the mitotic spindle.
Lauren T. Evans +5 more
semanticscholar +1 more source
Genes, Chromosomes and Cancer, Volume 62, Issue 2, Page 93-100, February 2023., 2023 Abstract Chromosomal instability is a common feature in malignant tumors. Previous studies have indicated that inactivation of the classical tumor suppressor genes RB1, CDKN2A, and TP53 may contribute to chromosomal aberrations in cancer by disrupting different aspects of the cell cycle and DNA damage checkpoint machinery.
Natalie Andersson +6 more
wiley +1 more source
Centrosome-phagy: implications for human diseases
Cell & Bioscience, 2021 Autophagy is a prominent mechanism to preserve homeostasis and the response to intracellular or extracellular stress. Autophagic degradation can be selectively targeted to dysfunctional subcellular compartments.
Qi Wu +4 more
doaj +1 more source
Regulated changes in material properties underlie centrosome disassembly during mitotic exit
Journal of Cell Biology, 2020 Centrosomes withstand microtubule-mediated forces during spindle assembly, yet they are disassembled by similar forces during mitotic exit. Mittasch et al.
Matthäus Mittasch +8 more
semanticscholar +1 more source