Results 21 to 30 of about 74,905 (314)
Choreography of the centrosome [PDF]
Heliyon, 2020 More than a century ago, the centrosome was discovered and described as "the true division organ of the cell". Electron microscopy revealed that a centrosome is an amorphous structure or pericentriolar protein matrix that surrounds a pair of well-organized centrioles.
openaire +4 more sources
Polo-like kinase 1 independently controls microtubule-nucleating capacity and size of the centrosome
bioRxiv, 2020 Centrosomes are composed of a centriolar core surrounded by a pericentriolar material (PCM) matrix that docks microtubule-nucleating γ-tubulin complexes.
Midori Ohta +7 more
semanticscholar +1 more source
Centriolar distal appendages activate the centrosome‐PIDDosome‐p53 signalling axis via ANKRD26
EMBO Journal, 2020 Centrosome amplification results into genetic instability and predisposes cells to neoplastic transformation. Supernumerary centrosomes trigger p53 stabilization dependent on the PIDDosome (a multiprotein complex composed by PIDD1, RAIDD and Caspase‐2 ...
Matteo Burigotto +11 more
semanticscholar +1 more source
Regulated changes in material properties underlie centrosome disassembly during mitotic exit
Journal of Cell Biology, 2020 Centrosomes withstand microtubule-mediated forces during spindle assembly, yet they are disassembled by similar forces during mitotic exit. Mittasch et al.
Matthäus Mittasch +8 more
semanticscholar +1 more source
EMBO Journal, 2020 Mutations in centrosome genes deplete neural progenitor cells (NPCs) during brain development, causing microcephaly. While NPC attrition is linked to TP53‐mediated cell death in several microcephaly models, how TP53 is activated remains unclear.
Thao P Phan +11 more
semanticscholar +1 more source
Centrosome dysfunction: a link between senescence and tumor immunity
Signal Transduction and Targeted Therapy, 2020 Centrosome aberrations are hallmarks of human cancers and contribute to the senescence process. Structural and numerical centrosome abnormalities trigger mitotic errors, cellular senescence, cell death, genomic instability and/or aneuploidy, resulting in
Qi Wu +4 more
semanticscholar +1 more source
Dual pathway spindle assembly increases both the speed and the fidelity of mitosis [PDF]
, 2011 Roughly half of all animal somatic cell spindles assemble by the classical prophase pathway, in which the centrosomes separate ahead of nuclear envelope breakdown (NEBD).
Cross, R. A. +2 more
core +2 more sources
Primary cilium-dependent cAMP/PKA signaling at the centrosome regulates neuronal migration
Science Advances, 2020 The primary cilium regulates neuronal migration via cyclic AMP production activating protein kinase A at the centrosome. The primary cilium (PC) is a small centrosome-assembled organelle, protruding from the surface of most eukaryotic cells.
J. Stoufflet +9 more
semanticscholar +1 more source
Emerging roles of centrosome cohesion
Open Biology, 2022 The centrosome, consisting of centrioles and the associated pericentriolar material, is the main microtubule-organizing centre (MTOC) in animal cells.
Hairuo Dang, Elmar Schiebel
doaj +1 more source
Generation and Characterization of a Tissue-Specific Centrosome Indicator Mouse Line. [PDF]
, 2016 Centrosomes are major microtubule organizing centers (MTOCs) that play an important role in chromosome segregation during cell division. Centrosomes provide a stable anchor for microtubules, constituting the centers of the spindle poles in mitotic cells,
Chen, Ju +2 more
core +2 more sources