Results 21 to 30 of about 17,279 (253)
Centrosome dysfunction: a link between senescence and tumor immunity
Signal Transduction and Targeted Therapy, 2020 Centrosome aberrations are hallmarks of human cancers and contribute to the senescence process. Structural and numerical centrosome abnormalities trigger mitotic errors, cellular senescence, cell death, genomic instability and/or aneuploidy, resulting in
Qi Wu +4 more
semanticscholar +1 more source
Primary cilium-dependent cAMP/PKA signaling at the centrosome regulates neuronal migration
Science Advances, 2020 The primary cilium regulates neuronal migration via cyclic AMP production activating protein kinase A at the centrosome. The primary cilium (PC) is a small centrosome-assembled organelle, protruding from the surface of most eukaryotic cells.
J. Stoufflet +9 more
semanticscholar +1 more source
Molecular Informatics, Volume 42, Issue 1, January 2023., 2023 Abstract Modification of the tubulin‐microtubule (Tub‐Mts) system has generated effective strategies for developing different treatments for cancer. A huge amount of clinical data about inhibitors of the tubulin‐microtubule system have supported and validated the studies on this pharmacological target.
Edgar López‐López +2 more
wiley +1 more source
The phosphorylation of PHF5A by TrkA-ERK1/2-ABL1 cascade regulates centrosome separation
Cell Death and Disease, 2023 During interphase, the newly duplicated pairs of centrosomes are held together by a centrosome linker, and the centrosome separation needs the disruption of this linker to induce the duplicated centrosomes separating into two distinct microtubule ...
Chen Song +10 more
doaj +1 more source
Acto-myosin network geometry defines centrosome position
bioRxiv, 2020 The centrosome is the main organizer of microtubules and as such, its position is a key determinant of polarized cell functions. As the name says, the default position of the centrosome is considered to be the cell geometrical center.
A. J. Jimenez +8 more
semanticscholar +1 more source
A little less aggregation a little more replication: Viral manipulation of stress granules
WIREs RNA, Volume 14, Issue 1, January/February 2023., 2023 Viruses depend entirely on host machinery and therefore aim to conquer the host and defeat its defenses to co‐opt its resources for its own replication. Improved understanding of how viruses counteract host immune responses such as stress granule assembly, detailed here, will inform future antiviral therapeutic strategies.
Matthew J. Brownsword, Nicolas Locker
wiley +1 more source
Centrosome Biology: The Ins and Outs of Centrosome Assembly [PDF]
Current Biology, 2015 As a microtubule-organizing center, the centrosome undergoes a dramatic increase in size - via expansion of the pericentriolar material - during mitosis. Recent work reveals shared assembly properties of a protein scaffold that facilitates and supports this expansion, a process critical to spindle assembly.
Laurence Pelletier +2 more
openaire +3 more sources
Cep295 is a conserved scaffold protein required for generation of a bona fide mother centriole
Nature Communications, 2016 Newly formed centrioles mature into functional mother centrioles. Here the authors show that the scaffolding protein Cep295 is recruited to the procentriole assembly site and assists daughter centriole assembly and daughter-to-mother centriole conversion.
Yuki Tsuchiya +4 more
doaj +1 more source
Emerging roles of centrosome cohesion
Open Biology, 2022 The centrosome, consisting of centrioles and the associated pericentriolar material, is the main microtubule-organizing centre (MTOC) in animal cells.
Hairuo Dang, Elmar Schiebel
doaj +1 more source
Narrow escape problem in two-shell spherical domains [PDF]
Phys. Rev. E 104, 044124 (2021), 2021 Intracellular transport in living cells is often spatially inhomogeneous with an accelerated effective diffusion close to the cell membrane and a ballistic motion away from the centrosome due to active transport along actin filaments and microtubules, respectively.
arxiv +1 more source