Results 31 to 40 of about 17,279 (253)
An intact centrosome is required for the maintenance of polarization during directional cell migration. [PDF]
PLoS ONE, 2010 Establishing and maintaining polarization is critical during cell migration. It is known that the centrosome contains numerous proteins whose roles of organizing the microtubule network range include nucleation, stabilization and severing.
Nicole M Wakida +3 more
doaj +1 more source
Physical Basis of Large Microtubule Aster Growth [PDF]
eLife 2016;5:e19145, 2016 Microtubule asters - radial arrays of microtubules organized by centrosomes - play a fundamental role in the spatial coordination of animal cells. The standard model of aster growth assumes a fixed number of microtubules originating from the centrosomes.
arxiv +1 more source
The Cep57-pericentrin module organizes PCM expansion and centriole engagement
Nature Communications, 2019 Centriole disengagement occurs towards mitotic exit and involves cleavage of pericentrin, a component of the pericentriolar material. Here the authors show that depletion of the centrosomal protein Cep57 leads to precocious centriole disengagement, and ...
Koki Watanabe +4 more
doaj +1 more source
Maintaining centrosomes and cilia [PDF]
Journal of Cell Science, 2017 ABSTRACT Centrosomes and cilia are present in organisms from all branches of the eukaryotic tree of life. These structures are composed of microtubules and various other proteins, and are required for a plethora of cell processes such as structuring the cytoskeleton, sensing the environment, and motility.
Sascha Werner +2 more
openaire +3 more sources
IFT proteins spatially control the geometry of cleavage furrow ingression and lumen positioning
Nature Communications, 2017 Cytokinesis relies on central spindle organization and provides a spatial landmark for lumen formation. Here, the authors show that intraflagellar transport proteins are required for the localization of the cytokinetic regulator Aurora B and subsequent ...
Nicolas Taulet +8 more
doaj +1 more source
Centrosome loss or amplification does not dramatically perturb global gene expression in Drosophila
Biology Open, 2012 Summary Centrosome defects are a common feature of many cancers, and they can predispose fly brain cells to form tumours. In flies, centrosome defects perturb the asymmetric division of the neural stem cells, but it is unclear how this might lead to ...
Janina Baumbach +2 more
doaj +1 more source
Centrosome Defects in Hematological Malignancies: Molecular Mechanisms and Therapeutic Insights
Blood Science, 2022 Defects in centrosomes are associated with a broad spectrum of hematological malignancies, such as leukemia and lymphoma. Centrosomes in these malignancies display both numerical and structural aberrations, including alterations in the number and size of
Mingzheng Hu, Yijie Wang, Jun Zhou
doaj +1 more source
Cancer: CINful Centrosomes [PDF]
Current Biology, 2009 The regulation of centrosome number is lost in many tumors and the presence of extra centrosomes correlates with chromosomal instability. Recent work now reveals how extra centrosomes cause chromosome mis-segregation in tumor cells.
Duane A. Compton, Samuel F. Bakhoum
openaire +3 more sources
FEBS Letters, 2002 The centrosome is the major microtubule‐organizing center of animal cells. It influences cell shape and polarity and directs the formation of the bipolar mitotic spindle. Numerical and structural centrosome aberrations have been implicated in disease, notably cancer.
Meraldi, P., Nigg, E. A.
openaire +3 more sources
Cortical microtubule nucleation can organise the cytoskeleton of $Drosophila$ oocytes to define the anteroposterior axis [PDF]
eLife 4, e06088 (2015), 2015 Many cells contain non-centrosomal arrays of microtubules (MT), but the assembly, organisation and function of these arrays are poorly understood. We present the first theoretical model for the non-centrosomal MT cytoskeleton in $Drosophila$ oocytes, in which $bicoid$ and $oskar$ mRNAs become localised to establish the anterior-posterior body axis ...
arxiv +1 more source