Results 41 to 50 of about 17,279 (253)
The Identification and Functional Analysis of mRNA Localizing to Centrosomes
Frontiers in Cell and Developmental Biology, 2021 Centrosomes are multifunctional organelles tasked with organizing the microtubule cytoskeleton required for genome stability, intracellular trafficking, and ciliogenesis.
Hala Zein-Sabatto, Dorothy A. Lerit
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Site-specific phosphorylation of ZYG-1 regulates ZYG-1 stability and centrosome number
iScience, 2023 Summary: Spindle bipolarity is critical for genomic integrity. As centrosome number often dictates bipolarity, tight control of centrosome assembly is vital for faithful cell division.
Jeffrey C. Medley +8 more
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Collective behavior of minus-ended motors in mitotic microtubule asters gliding towards DNA [PDF]
2014 Phys. Biol. 11 016008, 2014 Microtubules (MTs) nucleated by centrosomes form star-shaped structures referred to as asters. Aster motility and dynamics is vital for genome stability, cell division, polarization and differentiation. Asters move either towards the cell center or away from it.
arxiv +1 more source
Cells, 2021 The timing of centrosome separation and the distance moved apart influence the formation of the bipolar spindle, affecting chromosome stability. Epidermal growth factor receptor (EGFR) signaling induces early centrosome separation through downstream G ...
Clara Reglero +4 more
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The Centrosome and the Primary Cilium: The Yin and Yang of a Hybrid Organelle
Cells, 2019 Centrosomes and primary cilia are usually considered as distinct organelles, although both are assembled with the same evolutionary conserved, microtubule-based templates, the centrioles.
V. Joukov, A. De Nicolo
semanticscholar +1 more source
Centrosome Biology: Polymer-Based Centrosome Maturation [PDF]
Current Biology, 2017 The molecular mechanisms that control how the centrosome increases in size and microtubule nucleation capacity during mitosis have remained elusive. Recent work using in vitro assays provide exciting clues as to how this may occur.
Gagan D. Gupta +2 more
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Defect driven shapes in nematic droplets: analogies with cell division [PDF]
Soft Matter 13, 1257 (2017), 2016 Building on the striking similarity between the structure of the spindle during mitosis in living cells and nematic textures in confined liquid crystals, we use a continuum model of two-dimensional nematic liquid crystal droplets, to examine the physical aspects of cell division.
arxiv +1 more source
APC/CFZR-1 Controls SAS-5 Levels To Regulate Centrosome Duplication in Caenorhabditis elegans
G3: Genes, Genomes, Genetics, 2017 As the primary microtubule-organizing center, centrosomes play a key role in establishing mitotic bipolar spindles that secure correct transmission of genomic content.
Jeffrey C. Medley +3 more
doaj +1 more source
Frontiers in Cell and Developmental Biology, 2020 Mammalian haploid somatic cells are unstable and prone to diploidize, but the cause of haploid instability remains largely unknown. Previously, we found that mammalian haploid somatic cells suffer chronic centrosome loss stemming from the uncoupling of ...
Koya Yoshizawa +3 more
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