Results 61 to 70 of about 55,767 (297)
, 2014 The underlying etiologies of genetic congenital microcephaly are complex and multifactorial. Recently, with the exponential growth in the identification and characterization of novel genetic causes of congenital microcephaly, there has been a ...
Agha +129 more
core +1 more source
Frontiers in Cell and Developmental Biology, 2020 Mammalian haploid somatic cells are unstable and prone to diploidize, but the cause of haploid instability remains largely unknown. Previously, we found that mammalian haploid somatic cells suffer chronic centrosome loss stemming from the uncoupling of ...
Koya Yoshizawa +3 more
doaj +1 more source
The Neoplasia as embryological phenomenon and its implication in the animal evolution and the origin of cancer. III. The role of flagellated cell fusion in the formation of the first animal and evolutionary clues to the Warburg effect [PDF]
arXiv, 2022 Cytasters have been underestimated in terms of their potential relevance to embryonic development and evolution. From the perspective discussed herein, structures such as the multiciliated cells of comb rows and balancers supporting mineralized statoliths and macrocilia in Beroe ovata point to a past event of multiflagellate fusion in the origin of ...
arxiv
Optimality of spatially inhomogeneous search strategies [PDF]
Phys. Rev. Lett. 117, 068101 (2016), 2016 We consider random search processes alternating stochastically between diffusion and ballistic motion, in which the distribution function of ballistic motion directions varies from point to point in space. The specific space dependence of the directional distribution together with the switching rates between the two modes of motion establishes a ...
arxiv +1 more source
The small GTPase Rab29 is a common regulator of immune synapse assembly and ciliogenesis [PDF]
, 2015 Acknowledgements We wish to thank Jorge Galán, Gregory Pazour, Derek Toomre, Giuliano Callaini, Joel Rosenbaum, Alessandra Boletta and Francesco Blasi for generously providing reagents and for productive discussions, and Sonia Grassini for technical ...
A Batista +51 more
core +1 more source
Mechanical stability of bipolar spindle assembly [PDF]
, 2016 Assembly and stability of mitotic spindle is governed by the interplay of various intra-cellular forces, e.g. the forces generated by motor proteins by sliding overlapping anti-parallel microtubules (MTs) polymerized from the opposite centrosomes, the interaction of kinetochores with MTs, and the interaction of MTs with the chromosomes arms.
arxiv +1 more source
The role of vimentin-nuclear interactions in persistent cell motility through confined spaces [PDF]
, 2021 The ability of cells to move through small spaces depends on the mechanical properties of the cellular cytoskeleton and on nuclear deformability. In mammalian cells, the cytoskeleton is comprised of three interacting, semi-flexible polymer networks: actin, microtubules, and intermediate filaments (IF).
arxiv +1 more source
Centrosome Remodelling in Evolution [PDF]
Cells, 2018 The centrosome is the major microtubule organizing centre (MTOC) in animal cells. The canonical centrosome is composed of two centrioles surrounded by a pericentriolar matrix (PCM). In contrast, yeasts and amoebozoa have lost centrioles and possess acentriolar centrosomes—called the spindle pole body (SPB) and the nucleus-associated body (NAB ...
Daisuke Ito, Mónica Bettencourt-Dias
openaire +3 more sources
The Centrosome: Conclusions and Perspectives
Cells, 2022 The centrosome consists of two centrioles surrounded by pericentriolar material [...]
Rustem E. Uzbekov, Tomer Avidor-Reiss
openaire +3 more sources
Cigarette smoke condensate induces centrosome clustering in normal lung epithelial cells
Cancer Medicine, 2023 Background Unlike normal cells, cancer cells frequently have multiple centrosomes that can cluster to form bipolar mitotic spindles and allow for successful cell division.
Jose Thaiparambil +4 more
doaj +1 more source