Results 61 to 70 of about 74,905 (314)

A mitotic kinase scaffold depleted in testicular seminomas impacts spindle orientation in germ line stem cells. [PDF]

, 2015
Correct orientation of the mitotic spindle in stem cells underlies organogenesis. Spindle abnormalities correlate with cancer progression in germ line-derived tumors.
Bucko, Paula, Canton, David, Gelman, Irwin, Hehnly, Heidi, Langeberg, Lorene K, Ogier, Leah, Santana, L Fernando, Scott, John D, Wordeman, Linda   +8 more
core   +1 more source

Centrosome-Associated NDR Kinase Regulates Centrosome Duplication [PDF]

Molecular Cell, 2007
Human NDR kinases are upregulated in some cancer types, yet their functions still remain undefined. Here, we report the first known function of a mammalian NDR kinase by demonstrating that human NDR directly contributes to centrosome duplication. A subpopulation of endogenous NDR localizes to centrosomes in a cell-cycle-dependent manner. Overexpression
Hergovich, Alexander, Lamla, Stefan, Nigg, Erich A., Hemmings, Brian A.   +3 more
openaire   +3 more sources

FancJ regulates interstrand crosslinker induced centrosome amplification through the activation of polo-like kinase 1

Biology Open, 2013
Summary DNA damage response (DDR) and the centrosome cycle are two of the most critical processes for maintaining a stable genome in animals. Sporadic evidence suggests a connection between these two processes.
Jianqiu Zou, Fen Tian, Ji Li, Wyatt Pickner, Molly Long, Khosrow Rezvani, Hongmin Wang, Dong Zhang   +7 more
doaj   +1 more source

Interaction of CK1δ with γTuSC ensures proper microtubule assembly and spindle positioning. [PDF]

, 2015
Casein kinase 1δ (CK1δ) family members associate with microtubule-organizing centers (MTOCs) from yeast to humans, but their mitotic roles and targets have yet to be identified.
Agard, David A, Barnes, Georjana, Drubin, David G, Giddings, Thomas H, Han, Xuemei, Kollman, Justin, Lyon, Andrew, Moritz, Michelle, Peng, Yutian, Winey, Mark, Yates, John   +10 more
core   +1 more source

53BP1 and USP28 mediate p53 activation and G1 arrest after centrosome loss or extended mitotic duration

Journal of Cell Biology, 2016
Meitinger et al. perform a genome-wide CRISPR/Cas9 screen for centrinone resistance and identify a 53BP1-USP28 module as critical for communicating mitotic challenges to the p53 circuit and TRIM37 as an enforcer of the singularity of centrosome assembly.
Franz Meitinger, J. Anzola, M. Kaulich, Amelia Richardson, Joshua D Stender, C. Benner, C. Glass, S. Dowdy, A. Desai, A. Shiau, K. Oegema   +10 more
semanticscholar   +1 more source

Cigarette smoke condensate induces centrosome clustering in normal lung epithelial cells

Cancer Medicine, 2023
Background Unlike normal cells, cancer cells frequently have multiple centrosomes that can cluster to form bipolar mitotic spindles and allow for successful cell division.
Jose Thaiparambil, Chandra S. Amara, Subrata Sen, Nagireddy Putluri, Randa El‐Zein   +4 more
doaj   +1 more source

A USP28–53BP1–p53–p21 signaling axis arrests growth after centrosome loss or prolonged mitosis

Journal of Cell Biology, 2016
Lambrus et al. show that centrosome loss or a prolonged mitosis activates a USP28–53BP1–p53–p21 signaling axis that prevents the growth of cells with an increased propensity for mitotic errors.
Bramwell G. Lambrus, Vikas Daggubati, Yumi Uetake, Phillip Scott, Kevin M. Clutario, G. Sluder, A. Holland   +6 more
semanticscholar   +1 more source

CCDC102B functions in centrosome linker assembly and centrosome cohesion [PDF]

Journal of Cell Science, 2018
ABSTRACT The proteinaceous centrosome linker is an important structure that allows the centrosome to function as a single microtubule-organizing center (MTOC) in interphase cells. However, the assembly mechanism of the centrosome linker components remains largely unknown.
Yuqing Xia, Ning Huang, Zhiquan Chen, Fangyuan Li, Guiliang Fan, Dandan Ma, Jianguo Chen, Junlin Teng   +7 more
openaire   +3 more sources

Actin filaments regulate microtubule growth at the centrosome

bioRxiv, 2018
The centrosome is the main microtubule-organizing centre. It also organizes a local network of actin filaments. However, the precise function of the actin network at the centrosome is not well understood.
Daisuke Inoue, Dorian Obino, F. Farina, J. Gaillard, Christophe Guérin, L. Blanchoin, A. Lennon-Duménil, M. Théry   +7 more
semanticscholar   +1 more source

The Centrosome: Conclusions and Perspectives

Cells, 2022
The centrosome consists of two centrioles surrounded by pericentriolar material [...]
Rustem E. Uzbekov, Tomer Avidor-Reiss
openaire   +3 more sources