Results 71 to 80 of about 74,905 (314)

An intact centrosome is required for the maintenance of polarization during directional cell migration.

PLoS ONE, 2010
BackgroundEstablishing and maintaining polarization is critical during cell migration. It is known that the centrosome contains numerous proteins whose roles of organizing the microtubule network range include nucleation, stabilization and severing.
Nicole M Wakida, Elliot L Botvinick, Justin Lin, Michael W Berns   +3 more
doaj   +1 more source

Ccdc11 is a novel centriolar satellite protein essential for ciliogenesis and establishment of left-right asymmetry [PDF]

, 2016
The establishment of left–right (L-R) asymmetry in vertebrates is dependent on the sensory and motile functions of cilia during embryogenesis. Mutations in CCDC11 disrupt L-R asymmetry and cause congenital heart disease in humans, yet the molecular and ...
Betleja, Ewelina, John, Emily, Mahjoub, Moe R, Mitchell, Brian J, Moresco, James J, Silva, Erica, Spear, Philip, Yates, John R, III, Zhang, Siwei   +8 more
core   +2 more sources

Selective autophagy maintains centrosome integrity and accurate mitosis by turnover of centriolar satellites

Nature Communications, 2018
The centrosome is the master orchestrator of mitotic spindle formation and chromosome segregation in animal cells. Centrosome abnormalities are frequently observed in cancer, but little is known of their origin and about pathways affecting centrosome ...
Søs Grønbæk Holdgaard, V. Cianfanelli, Emanuela Pupo, M. Lambrughi, M. Lubas, Julie C Nielsen, Susana Eibes, Emiliano Maiani, Lea M. Harder, Nicole Wesch, M. M. Foged, K. Maeda, F. Nazio, L. R. de la Ballina, V. Dötsch, A. Brech, Lisa B. Frankel, M. Jäättelä, F. Locatelli, M. Barišić, J. Andersen, Simon Bekker-Jensen, A. Lund, V. Rogov, Elena Papaleo, Letizia Lanzetti, D. De Zio, F. Cecconi   +27 more
semanticscholar   +1 more source

Inactivation of PLK4-STIL Module Prevents Self-Renewal and Triggers p53-Dependent Differentiation in Human Pluripotent Stem Cells

Stem Cell Reports, 2018
Summary: Centrioles account for centrosomes and cilia formation. Recently, a link between centrosomal components and human developmental disorders has been established.
Tereza Renzova, Dasa Bohaciakova, Milan Esner, Veronika Pospisilova, Tomas Barta, Ales Hampl, Lukas Cajanek   +6 more
doaj   +1 more source

Astrin is required for the maintenance of sister chromatid cohesion and centrosome integrity [PDF]

, 2007
Faithful chromosome segregation in mitosis requires the formation of a bipolar mitotic spindle with stably attached chromosomes. Once all of the chromosomes are aligned, the connection between the sister chromatids is severed by the cysteine protease ...
Gruneberg, Ulrike, Kleylein-Sohn, Julia, Nigg, Erich A., Thein, Kerstin H.   +3 more
core   +3 more sources

STED nanoscopy of the centrosome linker reveals a CEP68-organized, periodic rootletin network anchored to a C-Nap1 ring at centrioles

Proceedings of the National Academy of Sciences of the United States of America, 2018
Significance The integrity of the centrosome linker that joints both centrosomes of a cell into one microtubule-organizing unit plays important roles in cell organization, chromosome segregation, and cancer development. However, little is known about the
R. Vlijm, Xue Li, Marko Panic, Diana Rüthnick, S. Hata, Frank Herrmannsdörfer, T. Kuner, M. Heilemann, J. Engelhardt, S. Hell, E. Schiebel   +10 more
semanticscholar   +1 more source

Localization of MLH3 at the Centrosomes [PDF]

International Journal of Molecular Sciences, 2014
Mutations in human DNA mismatch repair (MMR) genes are commonly associated with hereditary nonpolyposis colorectal cancer (HNPCC). MLH1 protein heterodimerizes with PMS2, PMS1, and MLH3 to form MutLα, MutLβ, and MutLγ, respectively. We reported recently stable expression of GFP-linked MLH3 in human cell lines.
Roesner, Lennart M, Mielke, Christian, Faehnrich, Silke, Merkhoffer, Yvonne, Dittmar, Kurt E J, Drexler, Hans G, Dirks, Wilhelm G   +6 more
openaire   +4 more sources

Organization of the Proteostasis Network of Membraneless Organelles

Advanced Science, EarlyView.
A comprehensive mapping of the proteostasis network (PN) across membraneless organelles (MLOs) reveals how central PN components coordinate MLO regulation. The analysis uncovers principles of specificity and promiscuity within the PN. The findings suggest that HSP70 chaperones act as generic MLO regulators, while client specific HSP70 co‐chaperones may
Christine M. Lim, Yuqi Bian, Alicia González Díaz, Frank Pun, Alex Zhavoronkov, Richard I. Morimoto, Michele Vendruscolo   +6 more
wiley   +1 more source

Tau-tubulin kinase 2 restrains microtubule-depolymerizer KIF2A to support primary cilia growth

Cell Communication and Signaling
Background Primary cilia facilitate cellular signalling and play critical roles in development, homeostasis, and disease. Their assembly is under the control of Tau-Tubulin Kinase 2 (TTBK2), a key enzyme mutated in patients with spinocerebellar ataxia ...
David Benk Vysloužil, Ondřej Bernatík, Eva Lánská, Tereza Renzová, Lucia Binó, Andrea Lacigová, Tereza Drahošová, Zdeněk Lánský, Lukáš Čajánek   +8 more
doaj   +1 more source

Immunofluorescence-based Determination of Centrosome Number in Tissue Samples

Bio-Protocol, 2019
Centrosome numerical abnormalities have been reported in a variety of tumors. Centrosome numbers in cancer cells display both inter-tumor and intra-tumor heterogeneity.
Mengdie Wang, Gregory Rogers, Anne Cress
doaj   +1 more source