Results 161 to 170 of about 6,648 (196)
Some of the next articles are maybe not open access.
Ceramidase and Signal Transduction
1997The deacylation of ceramide to form sphingosine in cells is the result of the activity of a group of enzymes referred to as the ceramidases (EC 3.5.1.23). There is a lysosomal form with an acidic pH optimum, a form with an alkaline pH optimum that may be associated with the plasma membrane and a form with a neutral pH optimum with a more limited tissue
openaire +1 more source
Ceramidases in the Regulation of Ceramide Levels and Function
2004Ceramide (Cer) occupies a central role in sphingolipid metabolism (Hannun and Luberto, 2000; Merrill and Wang, 1992). Ceramide metabolism commences in the de novo pathway with the condensation of serine and palmitoyl CoA, resulting in the formation of 3ketodihydrosphingosine (Merrill and Wang, 1992), which in turn serves as a precursor to ...
Samer, el Bawab +3 more
openaire +2 more sources
Ceramidase and Related Enzymes
2009Ceramide, composed of a fatty acid and a sphingoid base linked by an N-acyl linkage, is the common lipid moiety of glycosphingoslipids (GSLs). Ceramide is synthesized in the ER, from where it is transported to the Golgi apparatus, and glycosylated in a stepby- step manner by various glycosyltransferases.
openaire +1 more source
Biochimica et biophysica acta, 1975
It has been shown that tissues of patients with Farber's disease characteristically lack acid (pH 4.0) ceramidase. In normal cerebellum, however, ceramide cleavage and the reverse reaction, free fatty acid-dependent ceramide synthesis, both occur not only at pH 4.0 but also at pH 9.0, although normal kidney exhibits these activities only at pH 4.0 ...
M, Sugita +3 more
openaire +1 more source
It has been shown that tissues of patients with Farber's disease characteristically lack acid (pH 4.0) ceramidase. In normal cerebellum, however, ceramide cleavage and the reverse reaction, free fatty acid-dependent ceramide synthesis, both occur not only at pH 4.0 but also at pH 9.0, although normal kidney exhibits these activities only at pH 4.0 ...
M, Sugita +3 more
openaire +1 more source
Alkaline ceramidase family: The first two decades
Cellular Signalling, 2021Cungui Mao, Ruijuan Xu
exaly