Results 171 to 180 of about 7,033 (216)

Inhibitors of Ceramidases

Chemistry and Physics of Lipids, 2016
The topic of ceramidases has experienced an enormous boost during the last few years. Ceramidases catalyze the degradation of ceramide to sphingosine and fatty acids. Ceramide is not only the central hub of sphingolipid biosynthesis and degradation, it is also a key molecule in sphingolipid signaling, promoting differentiation or apoptosis.
Essa M, Saied, Christoph, Arenz
openaire   +2 more sources

The molecular medicine of acid ceramidase

Biological Chemistry, 2015
Abstract Acid ceramidase (N-acylsphingosine deacylase, EC 3.5.1.23; AC) is the lipid hydrolase responsible for the degradation of ceramide into sphingosine and free fatty acids within lysosomes. The enzymatic activity was first identified over four decades ago and is deficient in two rare inherited disorders, Farber lipogranulomatosis (Farber disease ...
Michael, Frohbergh, Xingxuan, He, Edward H, Schuchman   +2 more
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Acid and alkaline ceramidases of rat tissues

Biochemistry and Cell Biology, 1986
Ceramidase (N-acylsphingosine deacylase) was measured in rat tissue homogenates with N-[1-14C]oleoyl- and N-[9,10-3H]palmitoyl-sphingosine. Two activities were observed with pH optima of approximately 5 and 8. The activity at pH 8 exceeded that at pH 5 in all tissues and tissue areas examined, and both activities decreased in the following order ...
M W, Spence, S, Beed, H W, Cook
openaire   +2 more sources

Alkaline ceramidase 1–mediated platelet ceramide catabolism mitigates vascular inflammation and abdominal aortic aneurysm formation

Nature Cardiovascular Research, 2023
Xu Zhang, Ze Gong, Yicong Shen, Z. Cai, Liu Yang, Tao Zhang, Weihao Li, Yang Zhao, Shirong Zhu, Cihang Liu, Jin Wang, Xian Wang, Ruomei Qi, Junling Liu, Xiaoguang Lei, Wengong Wang, Changtao Jiang, Yi Fu, Wei Kong   +18 more
semanticscholar   +1 more source

Alkaline sphingomyelinases and ceramidases of the gastrointestinal tract

Chemistry and Physics of Lipids, 1999
In addition to the acid and neutral sphingomyelinases (SMase) that occur in most tissues, distinct alkaline sphingomyelinases occur in the mucosa of the gastrointestinal tract and human bile. These enzymes exhibit characteristic properties with regard to bile-salt dependence, protease resistance, and longitudinal distribution in the gut. Alkaline SMase
A, Nilsson, R D, Duan
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Ceramidase Deficiency in Farber's Disease (Lipogranulomatosis)

Science, 1972
Ceramidase activity could not be demonstrated in the kidney and cerebellum from a deceased patient with Farber's disease, whereas the activities of six control acid hydrolase enzymes appeared normal. This enzyme defect presumably accounts for the accumulation that has been described in two patients and may represent the biochemical basis of this ...
M, Sugita, J T, Dulaney, H W, Moser
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Ceramidase and Related Enzymes

2009
Ceramide, composed of a fatty acid and a sphingoid base linked by an N-acyl linkage, is the common lipid moiety of glycosphingoslipids (GSLs). Ceramide is synthesized in the ER, from where it is transported to the Golgi apparatus, and glycosylated in a stepby- step manner by various glycosyltransferases.
openaire   +1 more source

Ceramidases in the Regulation of Ceramide Levels and Function

2004
Ceramide (Cer) occupies a central role in sphingolipid metabolism (Hannun and Luberto, 2000; Merrill and Wang, 1992). Ceramide metabolism commences in the de novo pathway with the condensation of serine and palmitoyl CoA, resulting in the formation of 3ketodihydrosphingosine (Merrill and Wang, 1992), which in turn serves as a precursor to ...
Samer, el Bawab, Cungui, Mao, Lina M, Obeid, Yasuf A, Hannun   +3 more
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Ceramidase and Signal Transduction

1997
The deacylation of ceramide to form sphingosine in cells is the result of the activity of a group of enzymes referred to as the ceramidases (EC 3.5.1.23). There is a lysosomal form with an acidic pH optimum, a form with an alkaline pH optimum that may be associated with the plasma membrane and a form with a neutral pH optimum with a more limited tissue
openaire   +1 more source

Efficacy of ceramidase inhibition on human renal cell carcinoma: a cell culture study.

European Review for Medical and Pharmacological Sciences, 2023
F. Palit, C. Sezer, H. M. Kutlu, ID Orcid, C. Sezer   +4 more
semanticscholar   +1 more source