Results 121 to 130 of about 124,464 (285)

Sphingosine 1-phosphate in renal diseases [PDF]

, 2013
Because of its highly bioactive properties sphingosine 1-phosphate (S1P) is an attractive target for the treatment of several diseases. Since the expression of sphingosine kinases as well as S1P receptors was demonstrated in the kidney, questions about ...
Huwiler, Andrea, Koch, Alexander, Pfeilschifter, Josef Martin   +2 more
core   +2 more sources

Glycolipid abnormalities in a myoclonic variant of late infantile amaurotic idiocy

Journal of Lipid Research, 1970
Glycolipids were isolated from the brain of a patient with a myoclonic variant of late infantile amaurotic idiocy. There was an abnormal glycolipid pattern in gray and white matter.
Guenter G. Bartsch
doaj   +1 more source

Opportunistic pathogen Porphyromonas gingivalis targets the LC3B-ceramide complex and mediates lethal mitophagy resistance in oral tumors

iScience
Summary: Mechanisms by which Porphyromonas gingivalis (P. gingivalis) infection enhances oral tumor growth or resistance to cell death remain elusive. Here, we determined that P.
Megan Sheridan, Nityananda Chowdhury, Bridgette Wellslager, Natalia Oleinik, Mohamed Faisal Kassir, Han G. Lee, Mindy Engevik, Yuri Peterson, Subramanya Pandruvada, Zdzislaw M. Szulc, Özlem Yilmaz, Besim Ogretmen   +11 more
doaj   +1 more source

Regulation of Neuronal Stem Cell Proliferation in the Hippocampus by Endothelial Ceramide

Cellular Physiology and Biochemistry, 2016
Background/Aims: Major depressive disorder is one of the most common diseases in western countries. The disease is mainly defined by its psychiatric symptoms.
Anne Gulbins, Heike Grassmé, Richard Hoehn, Barbara Wilker, Matthias Soddemann, Marcus Kohnen, Michael J. Edwards, Johannes Kornhuber, Erich Gulbins   +8 more
doaj   +1 more source

Finding undetected protein associations in cell signaling by belief propagation

, 2011
External information propagates in the cell mainly through signaling cascades and transcriptional activation, allowing it to react to a wide spectrum of environmental changes.
A. Braunstein, A. Dagkessamanskaia, Aronova, Bashor, Bayati, Benayoun, Burkholder, C. Borgs, Dickson, Guldener, Huang, J. Chayes, J.- M. Francois, Jenness, King, Kuranda, Locasale, M. Bailly-Bechet, Miyake, Nickell, Pei, R. Zecchina, Roberts, Scott, Soufi, Spode, Thattai, Travers, Xenarios, Yosef, Zheng   +30 more
core   +3 more sources

Coupling In vitro and In vivo Paradigm Reveals a Dose Dependent Inhibition of Angiogenesis Followed by Initiation of Autophagy by C6-Ceramide

International Journal of Biological Sciences, 2011
The activity of N-hexanoyl-D-erythro-sphingosine, a C6-ceramide against angiogenesis was tested in vitro and in vivo. The effect of ceramide in inhibiting MCF-7 cancer cells was also determined.
Rishipal R. Bansode, Mohamed Ahmedna, Kurt R. Svoboda, Jack N. Losso
doaj  

Ceramide-Induced Apoptosis in Renal Tubular Cells: A Role of Mitochondria and Sphingosine-1-Phoshate

International Journal of Molecular Sciences, 2015
Ceramide is synthesized upon stimuli, and induces apoptosis in renal tubular cells (RTCs). Sphingosine-1 phosphate (S1P) functions as a survival factor. Thus, the balance of ceramide/S1P determines ceramide-induced apoptosis. Mitochondria play a key role
N. Ueda
semanticscholar   +1 more source

Demographic and clinical variables affecting mid‐ to late‐life trajectories of plasma ceramide and dihydroceramide species

Aging Cell, 2015
It has been increasingly recognized at the basic science level that perturbations in ceramide metabolism are associated with the development and progression of many age‐related diseases.
M. Mielke, V. Bandaru, Dingfen Han, Y. An, S. Resnick, L. Ferrucci, N. Haughey   +6 more
semanticscholar   +1 more source

Unravelling neuronal and glial differences in ceramide composition, synthesis, and sensitivity to toxicity

Communications Biology
Ceramides are lipids that play vital roles in complex lipid synthesis, membrane function, and cell signaling. Disrupted ceramide homeostasis is implicated in cell-death and several neurologic diseases.
John J. McInnis, Disha Sood, Lilu Guo, Michael R. Dufault, Mariana Garcia, Rachel Passaro, Grace Gao, Bailin Zhang, James C. Dodge   +8 more
doaj   +1 more source

Physico-chemical requirements and kinetics of membrane fusion of flavivirus-like particles. [PDF]

, 2015
Flaviviruses deliver their RNA genome into the host-cell cytoplasm by fusing their lipid envelope with a cellular membrane. Expression of the flavivirus pre-membrane and envelope glycoprotein genes in the absence of other viral genes results in the ...

core   +1 more source