Results 121 to 130 of about 110,293 (352)
iScienceSummary: Mechanisms by which Porphyromonas gingivalis (P. gingivalis) infection enhances oral tumor growth or resistance to cell death remain elusive. Here, we determined that P.
Megan Sheridan +11 more
doaj +1 more source
Intracellular trafficking of ceramide by ceramide transfer protein
Proceedings of the Japan Academy, Series B, 2010 The transport and sorting of lipids are fundamental to membrane biogenesis. In the synthesis of sphingolipids in mammalian cells, ceramide is newly produced at the endoplasmic reticulum (ER), and transported from the ER to the trans Golgi regions, where it is converted to sphingomyelin.
openaire +3 more sources
A Somatic Mutation in HIF-2α Affects Glucose and Lipid Metabolism via CD36 and Ceramide. [PDF]
FASEB JA mutation within the C‐terminal transactivation domain of HIF‐2α enhances Cd36 expression by increased transactivation activity, leading to ceramide accumulation and disruption of glucose and lipid metabolism. Inhibition of ceramide synthesis by myriocin reduces ceramide levels and ameliorates these metabolic disturbances.
Gao F +9 more
europepmc +2 more sources
Astrocytic ceramide as possible indicator of neuroinflammation
Journal of Neuroinflammation, 2019 Background Neurodegenerative diseases such as Alzheimer’s disease (AD), Parkinson’s disease dementia (PDD), and frontotemporal lobar dementia (FTLD) are characterized by progressive neuronal loss but differ in their underlying pathological mechanisms ...
Nienke M. de Wit +5 more
doaj +1 more source
Ibrain, EarlyView.In this review, agents such baicalein, troxerutin, epigallocatechin gallate, quercetin, melatonin, valproic acid, lithium, neurosteroid progesterone, as well as minocycline have been implicated as neuroprotective agents for irradiation‐induced neurological deficits. Also, agents such as glucocorticoids, methylphenidate, vitamin E, bisdemethoxycurcumin,
Seidu A. Richard +2 more
wiley +1 more source
Glycolipid abnormalities in a myoclonic variant of late infantile amaurotic idiocy
Journal of Lipid Research, 1970 Glycolipids were isolated from the brain of a patient with a myoclonic variant of late infantile amaurotic idiocy. There was an abnormal glycolipid pattern in gray and white matter.
Guenter G. Bartsch
doaj +1 more source
Molecular crosstalk via exosomes in lung cancer progression
Interdisciplinary Medicine, EarlyView.“Molecular and theranostics roles of exosomes in Lung Cancer.” Abstract Exosomes play a critical role in lung cancer metastasis, facilitating tumor progression through intercellular communication between cancer cells and the tumor microenvironment. These nanosized extracellular vesicles carry bioactive molecules such as proteins, nucleic acids, and ...
Rajib Dhar +3 more
wiley +1 more source
Ceramide Initiates NFκB-Mediated Caspase Activation in Neuronal Apoptosis
Neurobiology of Disease, 2000 The objective of the present study was to evaluate the role of ceramide in mediating apoptosis of dorsal root ganglion neurons induced by either nerve growth factor withdrawal or treatment with the chemotherapeutic agents suramin and cisplatin ...
Jagjit S. Gill, Anthony J. Windebank
doaj +1 more source
Finding undetected protein associations in cell signaling by belief propagation
, 2011 External information propagates in the cell mainly through signaling cascades and transcriptional activation, allowing it to react to a wide spectrum of environmental changes.
A. Braunstein +30 more
core +3 more sources
JEADV Clinical Practice, EarlyView.ABSTRACT Skin changes such as xerosis and pruritus are common complications among diabetes patients and may lead to serious adverse events such as diabetic foot syndrome and amputations. Evidence suggests that daily application of optimal skincare, including gentle cleansers and moisturizers, may help improve skin barrier function, preventing ...
Robert S. Kirsner +5 more
wiley +1 more source