Results 41 to 50 of about 124,464 (285)

C6-ceramide nanoliposomes target the Warburg effect in chronic lymphocytic leukemia. [PDF]

PLoS ONE, 2013
Ceramide is a sphingolipid metabolite that induces cancer cell death. When C6-ceramide is encapsulated in a nanoliposome bilayer formulation, cell death is selectively induced in tumor models. However, the mechanism underlying this selectivity is unknown.
Lindsay K Ryland, Ushma A Doshi, Sriram S Shanmugavelandy, Todd E Fox, Cesar Aliaga, Kathleen Broeg, Kendall Thomas Baab, Megan Young, Osman Khan, Jeremy K Haakenson, Nancy Ruth Jarbadan, Jason Liao, Hong-Gang Wang, David J Feith, Thomas P Loughran, Xin Liu, Mark Kester   +16 more
doaj   +1 more source

Feeding Stimulates Sphingosine-1-Phosphate Mobilization in Mouse Hypothalamus. [PDF]

, 2019
Previous studies have shown that the sphingolipid-derived mediator sphingosine-1-phosphate (S1P) reduces food intake by activating G protein-coupled S1P receptor-1 (S1PR1) in the hypothalamus.
Misto, Alessandra, Piomelli, Daniele, Realini, Natalia, Vozella, Valentina   +3 more
core   +1 more source

Apoptotic signaling through CD95 (Fas/Apo-1) activates an acidic sphingomyelinase. [PDF]

, 1994
Intracellular pathways leading from membrane receptor engagement to apoptotic cell death are still poorly characterized. We investigated the intracellular signaling generated after cross-linking of CD95 (Fas/Apo-1 antigen), a broadly expressed cell ...
Azuma, M, Cifone, MG, De Maria, R, Lanier, LL, Rippo, MR, Roncaioli, P, Santoni, A, Testi, R   +7 more
core   +2 more sources

Structure, functions and regulation of CERT, a lipid‐transfer protein for the delivery of ceramide at the ER–Golgi membrane contact sites

FEBS Letters, 2019
The inter‐organelle transport of lipids must be regulated to ensure appropriate lipid composition of each organelle. In mammalian cells, ceramide synthesised in the endoplasmic reticulum (ER) is transported to the trans‐Golgi regions, where ceramide is ...
Keigo Kumagai, K. Hanada
semanticscholar   +1 more source

Ceramide is More Effective than Shea Butter in Maintaining Skin Acidity

Berkala Ilmu Kesehatan Kulit dan Kelamin (Periodical of Dermatology and Venerology), 2022
Background: Skin is the largest organ that functions as a physical barrier. Stable skin pH can maximize its function. Ceramide and shea butter cream have components that maintain the skin pH in the stratum corneum. Purpose: The aim is to compare ceramide
Zilpa Widyastuti, Suci Widhiati
doaj   +1 more source

Turnover of endogenous ceramide in cultured normal and Farber fibroblasts

Journal of Lipid Research, 1997
De novo synthesis and turnover of endogenous ceramide in cultured skin fibroblasts from patients affected with Farber lipogranulomatosis were studied by biosynthetical labeling of cellular sphingolipids with [14C]serine.
G van Echten-Deckert, A Klein, T Linke, T Heinemann, J Weisgerber, K Sandhoff   +5 more
doaj   +1 more source

Genetic Determinants of Circulating Sphingolipid Concentrations in European Populations [PDF]

, 2009
Sphingolipids have essential roles as structural components of cell membranes and in cell signalling, and disruption of their metabolism causes several diseases, with diverse neurological, psychiatric, and metabolic consequences.
A Caspi, A Schulz, A. CecileJ.W. Janssens, Aaron Isaacs, AE Bielawska, Alan Wright, Anatoly V. Kirichenko, Andrew A. Hicks, Annette Peters, AR Morgan, Ayse Demirkan, B Devlin, Ben A. Oostra, C Gieger, C Pattaro, Caroline Hayward, Carsten Gnewuch, Christian Hengstenberg, Christine Schwienbacher, Christopher S. Franklin, Cornelia M. van Duijn, Cristian Pattaro, E Wang, F Dudbridge, Fabio Marroni, G Liebisch, G Liebisch, Gerd Schmitz, Gerhard Liebisch, Ghazal Zaboli, Greg Gibson, H.-Erich Wichmann, Harry Campbell, Heribert Schunkert, I Rudan, Igor Rudan, Inger Jonasson, Inke R. König, Irene Pichler, Irina V. Zorkoltseva, Ivana Kolcic, J Bras, J Erdmann, Jacqueline C. M. Witteman, James F. Wilson, Jeanette Erdmann, JL Dawkins, KJ Brookes, L Schaeffer, LN Clark, M Mehrabian, MA Simpson, N Amin, N Martinelli, Nick Hastie, NJ Samani, Ozren Polasek, P Wiesner, Peter P. Pramstaller, Peter Ugocsai, S Flamant, S Kathiresan, S Narayan, Sarah H. Wild, SL Schissel, ST Pruett, Stefan Schreiber, Susan Campbell, T Kolter, T Tanaka, Tatiana I. Axenovich, Thomas Meitinger, Ulf Gyllensten, V Vitart, Veronique Vitart, W Zheng, WC Nichols, Wilmar Igl, WL Holland, WM Chen, YS Aulchenko, YS Aulchenko, Yurii Aulchenko, Zrinka Biloglav, Åsa Johansson   +84 more
core   +7 more sources

Inhibiting Ceramide Synthesis Attenuates Hepatic Steatosis and Fibrosis in Rats With Non-alcoholic Fatty Liver Disease

Frontiers in Endocrinology, 2019
Non-alcoholic fatty liver disease (NAFLD) is one of the most common metabolic disorder diseases, which include a histological spectrum of conditions ranging from simple steatosis to non-alcoholic steatohepatitis (NASH).
Meng Jiang, Chun Li, Qiaoshu Liu, Aimin Wang, Minxiang Lei   +4 more
semanticscholar   +1 more source

Ceramide Kinase and Ceramide‐1‐Phosphate

, 2007
It has been over a decade since the sphingolipid ceramide-1-phosphate (C1P) was described. Until recently, only sparse reports on possible biological functions for this lipid have been published. A large number of reports have now surfaced demonstrating distinct biological mechanisms regulated by C1P produced from ceramide kinase (CERK).
Antonio Gómez-Muñoz, Nadia F. Lamour, Charles E. Chalfant, Charles E. Chalfant, Dayanjan S. Wijesinghe   +4 more
openaire   +4 more sources

Chemotherapy with ceramide in TNBC

Oncoscience, 2015
Metastasis remains the major cause of cancer-related mortality, and currently there is a lack of therapies to eliminate this risk. Therefore, it is of crucial interest to better understand this multi-step cellular process and find the best markers to identify patients who will develop early and distant relapse.
Legembre, Patrick, Micheau, Olivier, Ségui, Bruno   +2 more
openaire   +4 more sources