Results 61 to 70 of about 124,464 (285)
Ceramides and ceramide synthases in cancer: Focus on apoptosis and autophagy
European Journal of Cell Biology, 2023 Different studies corroborate a role for ceramide synthases and their downstream products, ceramides, in modulation of apoptosis and autophagy in the context of cancer. These mechanisms of regulation, however, appear to be context dependent in terms of ceramides' fatty acid chain length, subcellular localization, and the presence or absence of their ...
Javad Alizadeh +11 more
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Intestinal Acid Sphingomyelinase Protects From Severe Pathogen-Driven Colitis [PDF]
, 2019 Inflammatory diseases of the gastrointestinal tract are emerging as a global problem with increased evidence and prevalence in numerous countries. A dysregulated sphingolipid metabolism occurs in patients with ulcerative colitis and is discussed to ...
Becker, Katrin A. +9 more
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Characterization of neutral sphingolipids from chicken erythrocytes.
Journal of Lipid Research, 1985 The neutral sphingolipids from chicken erythrocytes were characterized. The total concentration of neutral sphingolipids was found to be 480 nmol/g of dry stroma.
T Shiraishi, Y Uda
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Cell Reports, 2021 Summary: We lack a mechanistic understanding of aging-mediated changes in mitochondrial bioenergetics and lipid metabolism that affect T cell function.
Silvia Vaena +14 more
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The low intestinal and hepatic toxicity of hydrolyzed fumonisin B1 correlates with its inability to alter the metabolism of sphingolipids [PDF]
, 2012 Fumonisins are mycotoxins frequently found as natural contaminants in maize, where they are produced by the plant pathogen Fusarium verticillioides. They are toxic to animals and exert their effects through mechanisms involving disruption of sphingolipid
Bracarense, Ana-Paula +8 more
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Separation of neutral glycosphingolipids and sulfatides by thin-layer chromatography
Journal of Lipid Research, 1967 Two one-dimensional systems for separation of glycolipids from total lipid extracts of tissues by thin-layer chromatography are described. System I used, as adsorbent, an alkaline mixture of silica gel without CaSO4 binder (75%) and magnesium silicate ...
Vladimir P. Skipski +2 more
doaj +1 more source
A simple, highly sensitive, and facile method to quantify ceramide at the plasma membrane
Journal of Lipid Research, 2023 The role of ceramide in biological functions is typically based on the elevation of cellular ceramide, measured by LC-MS in the total cell lysate. However, it has become increasingly appreciated that ceramide in different subcellular organelles regulates
Meaghan Greene +4 more
doaj +1 more source
Influence of the sebaceous gland density on the stratum corneum lipidome [PDF]
, 2018 The skin surface lipids (SSL) result from the blending of sebaceous and epidermal lipids, which derive from the sebaceous gland (SG) secretion and the permeability barrier of the stratum corneum (SC), respectively.
Camera, Emanuela +5 more
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Journal of Lipid Research, 2016 Nonalcoholic steatohepatitis (NASH) is a lipotoxic disease wherein activation of endoplasmic reticulum (ER) stress response and macrophage-mediated hepatic inflammation are key pathogenic features.
Eiji Kakazu, Amy Mauer, M. Yin, H. Malhi
semanticscholar +1 more source
Ceramide in Stress Response [PDF]
, 2010 Evidence has consistently indicated that activation of sphingomyelinases and/or ceramide synthases and the resulting accumulation of ceramide mediate cellular responses to stressors such as lipopolysaccharide, interleukin 1beta, tumor necrosis factor alpha, serum deprivation, irradiation and various antitumor treatments.
Mariana Nikolova-Karakashian +1 more
openaire +3 more sources