Eczema and ceramides: an update [PDF]
Contact Dermatitis, 2013 SummaryAlthough normal epidermal barrier function depends on numerous factors, including corneocytes, lipids, enzymes, pH, and calcium gradient, the key players are lipids and proteins in the stratum corneum. Atopic dermatitis is characterized by barrier abnormalities, such as the presence of filaggrin mutations in almost 50% of patients with moderate ...
Jungersted, Jakob Mutanu, Agner, Tove
openaire +4 more sources
Elevated plasma ceramide levels in post-menopausal women: a cross-sectional study. [PDF]
, 2019 Circulating ceramide levels are abnormally elevated in age-dependent pathologies such as cardiovascular diseases, obesity and Alzheimer's disease.
Armirotti, Andrea +9 more
core +1 more source
Water permeation through stratum corneum lipid bilayers from atomistic simulations [PDF]
, 2009 Stratum corneum, the outermost layer of skin, consists of keratin filled rigid non-viable corneocyte cells surrounded by multilayers of lipids. The lipid layer is responsible for the barrier properties of the skin.
Bemporad +43 more
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Increased de novo ceramide synthesis and accumulation in failing myocardium.
JCI Insight, 2017 Abnormal lipid metabolism may contribute to myocardial injury and remodeling. To determine whether accumulation of very long-chain ceramides occurs in human failing myocardium, we analyzed myocardial tissue and serum from patients with severe heart ...
R. Ji +15 more
semanticscholar +2 more sources
Ceramide-1-phosphate protection of cochlear hair cells against cisplatin ototoxicity
Toxicology Reports, 2016 Background: Ceramide-1-phosphate (C1P) is a phosphorylated form of ceramide. While ceramide is known to be an inducer of apoptosis of cochlear hair cells in cisplatin ototoxicity, little is known about the function of C1P in cochlear diseases.
Quang Le, Keiji Tabuchi, Akira Hara
doaj +1 more source
Lamellar and inverse micellar structures of skin lipids: Effect of templating [PDF]
, 2014 The outermost layer of skin, the stratum corneum (SC), comprises rigid corneocytes in a layered lipid matrix. Using atomistic simulations we find that the equilibrium phase of the SC lipids is inverse micellar.
Das, Chinmay +2 more
core +1 more source
The Role of Sphingosine-1-Phosphate and Ceramide-1-Phosphate in Inflammation and Cancer
Mediators of Inflammation, 2017 Inflammation is part of our body's response to tissue injury and pathogens. It helps to recruit various immune cells to the site of inflammation and activates the production of mediators to mobilize systemic protective processes.
N. Hait, A. Maiti
semanticscholar +1 more source
Lipids of the spleen in Gaucher's disease
Journal of Lipid Research, 1965 Thin-layer chromatography (TLC) was used to analyze lipids of eight spleens of patients with Gaucher's disease. Four non-Gaucher spleens were also analyzed.
William D. Suomi, Bernard W. Agranoff
doaj +1 more source
Ceramide species are elevated in human breast cancer and are associated with less aggressiveness
OncoTarget, 2018 Sphingolipids have emerged as key regulatory molecules in cancer cell survival and death. Although important roles of sphingolipids in breast cancer progression have been reported in experimental models, their roles in human patients are yet to be ...
Kazuki Moro +8 more
semanticscholar +1 more source
Identification and characterization of protein phosphatase 2C activation by ceramide[S]
Journal of Lipid Research, 2012 Ceramide is a bioactive sphingolipid with many associated biological outcomes, yet there is a significant gap in our current understanding of how ceramide mediates these processes.
David M. Perry +4 more
doaj +1 more source