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The Role of Ceramides in Metabolic and Cardiovascular Diseases [PDF]
Journal of Cardiovascular Development and DiseaseCeramides are bioactive sphingolipids increasingly recognized as mediators of cardiometabolic disease and residual cardiovascular risk. Accumulating evidence from experimental and clinical studies indicates that specific ceramide species contribute to ...
Manuel Gonzalez-Plascencia +3 more
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Selective Knockdown of Ceramide Synthases Reveals Opposite Roles of Different Ceramide Species in Cardiac Homeostasis [PDF]
MetabolitesBackground/Objectives: Sphingolipids are a class of lipids that play important structural and functional roles in the cell. Specific ceramide species are distinguishable through the fatty acid that is acylated to the sphingosine backbone, leading to ...
Alexandra M. Wiley +9 more
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Mitochondria-specific photorelease of ceramide induces apoptosis [PDF]
Journal of Lipid ResearchDeciphering the mechanisms by which bioactive intermediates of lipid metabolism influence cell behavior is a challenging task. We previously demonstrated that de novo synthesized ceramides are authentic transducers of apoptosis and that their CERT ...
Christian Schröer +5 more
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Frontiers in Behavioral Neuroscience, 2022 Increased long-chain C20:0 ceramides have been found in the serum of patients with depression. Moreover, ceramides are linked with increased microglia reactivity and inflammatory cytokine production, which are associated with depression.
Lubriel Sambolín-Escobales +9 more
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Assessment of plasma ceramides as predictor for subclinical atherosclerosis
Atherosclerosis Plus, 2021 Background and aims: Ceramides have been identified as novel biomarkers for cardiovascular disease (CVD) related events and mortality but their role in etiology of subclinical atherosclerosis is unknown.
Pashupati P. Mishra +10 more
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Ceramides during Pregnancy and Obstetrical Adverse Outcomes
Metabolites, 2023 Ceramides are a group of sphingolipids located in the external plasma membrane layer and act as messengers in cellular pathways such as inflammatory processes and apoptosis.
Maria Lantzanaki +5 more
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Frontiers in Molecular Biosciences, 2022 Clinical and preclinical studies suggest that increases in long-chain ceramides in blood may contribute to the development of depressive-like behavior.
Lubriel Sambolín-Escobales +8 more
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Frontiers in Cell and Developmental Biology, 2022 Ceramides represent a class of biologically active lipids that are involved in orchestrating vital signal transduction pathways responsible for regulating cellular differentiation and proliferation. However, accumulating clinical evidence have shown that
Youssef M. Shalaby +7 more
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Journal of Lipid Research, 2020 Ceramides are the predominant lipids in the stratum corneum (SC) and are crucial components for normal skin barrier function. Although the composition of various ceramide classes in the human SC has been reported, that in mice is still unknown, despite ...
Momoko Kawana +3 more
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Cardiovascular Diabetology, 2023 Background There is growing evidence that ceramides play a significant role in the onset and progression of non-alcoholic fatty liver disease (NAFLD), a highly prevalent condition in patients with type 2 diabetes associated with hepatic and ...
Damien Denimal +7 more
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