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Ceramide signaling in immunity: a molecular perspective [PDF]

Lipids in Health and Disease
Ceramides are bioactive lipids that play a crucial role in cellular signaling and structural integrity (Nat Rev Mol Cell Biol 19:175-191, 2018). As members of the sphingolipid family, ceramides consist of a sphingoid base attached to a fatty acid (Annu ...
Himani Thakkar, Vinnyfred Vincent, Bhagirath Chaurasia   +2 more
doaj   +2 more sources

Selective Knockdown of Ceramide Synthases Reveals Opposite Roles of Different Ceramide Species in Cardiac Homeostasis [PDF]

Metabolites
Background/Objectives: Sphingolipids are a class of lipids that play important structural and functional roles in the cell. Specific ceramide species are distinguishable through the fatty acid that is acylated to the sphingosine backbone, leading to ...
Alexandra M. Wiley, Melissa A. Krueger, Jessica O. Becker, Matthew Karasu, Nona Sotoodehnia, Jason G. Umans, Andrew N. Hoofnagle, Sina A. Gharib, Rheem A. Totah, Rozenn N. Lemaitre   +9 more
doaj   +2 more sources

Mitochondria-specific photorelease of ceramide induces apoptosis [PDF]

Journal of Lipid Research
Deciphering the mechanisms by which bioactive intermediates of lipid metabolism influence cell behavior is a challenging task. We previously demonstrated that de novo synthesized ceramides are authentic transducers of apoptosis and that their CERT ...
Christian Schröer, Matthijs Kol, Anna Koch, Emely Döffinger, Murali Annamalai, Joost C.M. Holthuis   +5 more
doaj   +2 more sources

Targeting ceramide metabolism to restore hypoxia-induced apoptosis in p53-deficient colon cancer cells. [PDF]

PLoS One
Mechleb K, Hourani N, Fakhry M, Alyamani OA, Hage-Sleiman R, Younes H, Fayad AA, Soudani N, Sakr A, Darwiche N, Nemer G, Saab R, Mrad M, Dbaibo G.   +13 more
europepmc   +2 more sources

Individual lipid alterations at the origin of neuronal Ceramide Synthase defects. [PDF]

PLoS Genet
Ziegler AB, Wesselmann C, Beckschäfer K, Wulf AL, Dhiman N, Soba P, Thiele C, Bauer R, Tavosanis G.   +8 more
europepmc   +2 more sources

Infusion of C20:0 ceramide into ventral hippocampus triggers anhedonia-like behavior in female and male rats

Frontiers in Behavioral Neuroscience, 2022
Increased long-chain C20:0 ceramides have been found in the serum of patients with depression. Moreover, ceramides are linked with increased microglia reactivity and inflammatory cytokine production, which are associated with depression.
Lubriel Sambolín-Escobales, Adariana Feliciano-Quiñones, Lizmarie Tirado-Castro, Cristina Suárez, Dariangelly Pacheco-Cruz, Nashaly Irizarry-Méndez, Wilfred Fonseca-Ferrer, Anixa Hernández-López, María Colón-Romero, James T. Porter   +9 more
doaj   +1 more source

Assessment of plasma ceramides as predictor for subclinical atherosclerosis

Atherosclerosis Plus, 2021
Background and aims: Ceramides have been identified as novel biomarkers for cardiovascular disease (CVD) related events and mortality but their role in etiology of subclinical atherosclerosis is unknown.
Pashupati P. Mishra, Binisha H. Mishra, Leo-Pekka Lyytikäinen, Mika Hilvo, Markus Juonala, Mika Kähönen, Nina Hutri-Kähönen, Dimitrios I. Fotiadis, Olli T. Raitakari, Reijo Laaksonen, Terho Lehtimäki   +10 more
doaj   +1 more source

Ceramides during Pregnancy and Obstetrical Adverse Outcomes

Metabolites, 2023
Ceramides are a group of sphingolipids located in the external plasma membrane layer and act as messengers in cellular pathways such as inflammatory processes and apoptosis.
Maria Lantzanaki, Theofanis Vavilis, Vikentia C. Harizopoulou, Helen Bili, Dimitrios G. Goulis, Dimitrios Vavilis   +5 more
doaj   +1 more source

High-Fat Diet and Short-Term Unpredictable Stress Increase Long-Chain Ceramides Without Enhancing Behavioral Despair

Frontiers in Molecular Biosciences, 2022
Clinical and preclinical studies suggest that increases in long-chain ceramides in blood may contribute to the development of depressive-like behavior.
Lubriel Sambolín-Escobales, Lizmarie Tirado-Castro, Cristina Suarez, Dariangelly Pacheco-Cruz, Wilfred Fonseca-Ferrer, Pragney Deme, Norman Haughey, Gladys Chompre, James T. Porter   +8 more
doaj   +1 more source

Role of Ceramides in the Molecular Pathogenesis and Potential Therapeutic Strategies of Cardiometabolic Diseases: What we Know so Far

Frontiers in Cell and Developmental Biology, 2022
Ceramides represent a class of biologically active lipids that are involved in orchestrating vital signal transduction pathways responsible for regulating cellular differentiation and proliferation. However, accumulating clinical evidence have shown that
Youssef M. Shalaby, Youssef M. Shalaby, Anas Al Aidaros, Anjana Valappil, Bassam R. Ali, Bassam R. Ali, Nadia Akawi, Nadia Akawi   +7 more
doaj   +1 more source