Results 11 to 20 of about 33,232 (287)

Many Ceramides [PDF]

Journal of Biological Chemistry, 2011
Intensive research over the past 2 decades has implicated ceramide in the regulation of several cell responses. However, emerging evidence points to dramatic complexities in ceramide metabolism and structure that defy the prevailing unifying hypothesis on ceramide function that is based on the understanding of ceramide as a single entity.
Yusuf A, Hannun, Lina M, Obeid
openaire   +2 more sources

Comparative profiling and comprehensive quantification of stratum corneum ceramides in humans and mice by LC/MS/MS[S]

Journal of Lipid Research, 2020
Ceramides are the predominant lipids in the stratum corneum (SC) and are crucial components for normal skin barrier function. Although the composition of various ceramide classes in the human SC has been reported, that in mice is still unknown, despite ...
Momoko Kawana, Masatoshi Miyamoto, Yusuke Ohno, Akio Kihara   +3 more
doaj   +1 more source

Plasma ceramides are associated with MRI-based liver fat content but not with noninvasive scores of liver fibrosis in patients with type 2 diabetes

Cardiovascular Diabetology, 2023
Background There is growing evidence that ceramides play a significant role in the onset and progression of non-alcoholic fatty liver disease (NAFLD), a highly prevalent condition in patients with type 2 diabetes associated with hepatic and ...
Damien Denimal, Sarah Béland-Bonenfant, Jean-Paul Pais-de-Barros, Alexia Rouland, Benjamin Bouillet, Laurence Duvillard, Bruno Vergès, Jean-Michel Petit   +7 more
doaj   +1 more source

Neutral Ceramidase Is Required for the Reproduction of Brown Planthopper, Nilaparvata lugens (Stål)

Frontiers in Physiology, 2021
Ceramides are bioactive sphingolipids that have been implicated in insect development; however, their role in insect reproduction remains poorly understood.
Xiao-Xiao Shi, Mu-Fei Zhu, Ni Wang, Yuan-Jie Huang, Yuan-Jie Huang, Min-Jing Zhang, Chao Zhang, Soomro A. Ali, Wen-Wu Zhou, Chuanxi Zhang, Cungui Mao, Zeng-Rong Zhu, Zeng-Rong Zhu   +12 more
doaj   +1 more source

The Role of Ceramides in Diabetes and Cardiovascular Disease Regulation of Ceramides by Adipokines

Frontiers in Endocrinology, 2020
Metabolic dysfunction is intertwined with the pathophysiology of both diabetes and cardiovascular disease. Recently, one particular lipid class has been shown to influence the development and sustainment of these diseases: ceramides.
Bianca C. Field, Ruth Gordillo, Philipp E. Scherer, Philipp E. Scherer   +3 more
doaj   +1 more source

Blood-brain barrier permeability analysis of plant ceramides.

PLoS ONE, 2020
Ceramides, a type of sphingolipid, are cell membrane components and lipid mediators that modulate a variety of cell functions. In plants, ceramides are mostly present in a glucosylated glucosylceramide (GlcCer) form.
Koichi Eguchi, Daisuke Mikami, Hui Sun, Takuya Tsumita, Kaori Takahashi, Katsuyuki Mukai, Kohei Yuyama, Yasuyuki Igarashi   +7 more
doaj   +1 more source

Targeting Ceramides and Adiponectin Receptors in the Islet of Langerhans for Treating Diabetes

Molecules, 2022
Ceramides belong to the sphingolipid family and represent the central hub of the sphingolipid network. In obesity, oversupply of saturated fatty acids including palmitate raises ceramide levels which can be detrimental to cells.
Wen-hong Li
doaj   +1 more source

Identification and quantitation of free ceramides in human platelets

Journal of Lipid Research, 1972
Free ceramides were isolated from human platelets. Their structures were unequivocally determined by gas–liquid chromatography–mass spectrometry of the trimethylsilyl ether derivatives.
William Krivit, Sven Hammarström
doaj   +1 more source

Ceramides and phospholipids in plasma extracellular vesicles are associated with high risk of major cardiovascular events after carotid endarterectomy

Scientific Reports, 2022
Ceramides and phosphatidylcholines (PCs) are bioactive lipids and lipid bilayer membrane components. Distinct ceramides/PCs (ratios) predict cardiovascular outcome in patients with coronary artery disease.
Nathalie Timmerman, Farahnaz Waissi, Mirthe Dekker, Gert J. de Borst, Joelle van Bennekom, Robbert J. de Winter, Mika Hilvo, Antti Jylhä, Gerard Pasterkamp, Dominique P. V. de Kleijn, Reijo Laaksonen   +10 more
doaj   +1 more source

Whole picture of human stratum corneum ceramides, including the chain-length diversity of long-chain bases

Journal of Lipid Research, 2022
Ceramides are essential lipids for skin permeability barrier function, and a wide variety of ceramide species exist in the stratum corneum (SC). Although ceramides with long-chain bases (LCBs) of various lengths have been identified in the human SC, a ...
Madoka Suzuki, Yusuke Ohno, Akio Kihara
doaj   +1 more source