Results 91 to 100 of about 459,917 (239)

Organoid Brain‐Machine‐Interface Devices for Central Nervous System Repair

Advanced Science, EarlyView.
We envision organoid brain‐machine‐interface (Organoid‐BMI) devices as new biohybrid bidirectional communication pathways to connect the human CNS and the external world for personalized CNS repair and regeneration. ABSTRACT Central nervous system (CNS) repair and regeneration suffer from tremendous clinical challenges due to current limitations in ...
Yantao Xing, Yang Yang, Zichen Hong, Chunhui Tian, Huiyu Chu, Susanne Clara Prokop, Hongwei Cai, Mingxia Gu, Jason Tchieu, Ken Mackie, Feng Guo   +10 more
wiley   +1 more source

A brain metastasis model for breast cancer using human embryonic stem cell-derived cerebral organoids [PDF]

, 2022
Background Breast cancer is a common cause of brain metastasis. Although breast cancer has relatively high survival rates, its survival rate after metastasis to the brain is lower.
Min Young Lee, Mu Seog Choe
core   +1 more source

Electrophysiological Analysis of Brain Organoids: Current Approaches and Advancements

Frontiers in Neuroscience, 2021
Brain organoids, or cerebral organoids, have become widely used to study the human brain in vitro. As pluripotent stem cell-derived structures capable of self-organization and recapitulation of physiological cell types and architecture, brain organoids ...
Austin P. Passaro, Austin P. Passaro, Steven L. Stice, Steven L. Stice, Steven L. Stice   +4 more
doaj   +1 more source

Functionalized Biomimetic Scaffolds for Human‐Derived Auditory Neural Circuit Construction

Advanced Science, EarlyView.
In Vitro Auditory Circuit Model. ABSTRACT Damage to auditory circuits results in sensorineural hearing loss. However, the scarcity of human inner ear tissue significantly hinders the development of therapies to preserve auditory function, creating a critical need for reliable in vitro models.
Pan Feng, Qian Zhu, Yusong Wang, Hao Rong, Xu Zhang, Fuchun Wang, Tianqi Yu, Wenxuan Wang, Jing Li, Lei Tian, Menghui Liao, Renjie Chai, Yangnan Hu   +12 more
wiley   +1 more source

Síndrome de vigilia sin respuesta y de mínima conciencia [PDF]

, 2021
El presente documento recoge el resumen y las conclusiones de un taller dedicado a uno de los segmentos de población con daño cerebral adquirido (DCA) que, junto al de niños con DCA y a las personas con trastorno conductual severo, constituyen ...
Federación Española de Daño Cerebral
core  

Remodeling and repair of the damaged brain: the potential and challenges of organoids for ischaemic stroke

Journal of Translational Medicine
Ischemic stroke induces irreversible cerebral tissue damage, a condition exacerbated by the brain’s limited endogenous neuroplasticity and inability to regenerate neurons.
Yi-Xuan Hao, Chen-Rui Li, Zhi-Jie Lu, Nan Kong, Rong-Hua Huang, Shu-Yan Ma, Wen-Fei Zhou, Hao Jiao, Yue Qiu, Yuan-Feng Yu, Bing-Wei Lv, Hai-Liang Tang, Jian Chen, Nai-Li Wei   +13 more
doaj   +1 more source

Gestational Hypoxia Disrupts Medial Ganglionic Eminence Progenitor Dynamics and Interneuron Development in Schizophrenia

Advanced Science, EarlyView.
FES‐derived MGE spheroids exhibit progenitor‐stage alterations in developmental trajectory and hypoxia‐responsive transcriptional programs, followed by functional disruption. Gestational hypoxia recapitulates impaired progenitor proliferation, shortened cell‐cycle progression, interneuron developmental abnormalities, and schizophrenia‐like behaviors in
Peiyan Ni, Qiancheng Zhang, Youhui Jiang, Huiying Yao, Chuqing Zhou, Xiaoyi Tian, Shiyingnan Gao, Jun Zhao, Xinyi Ren, Naxin Xu, Mengshan Fu, Liansheng Zhao, Xueyu Qi, Xueli Yu, Wanjun Guo, Sangmi Chung, Fan Guo, Tao Li   +17 more
wiley   +1 more source

Engineering organoids as cerebral disease models

Current Opinion in Biotechnology
Cerebral organoids pioneered in replicating complex brain tissue architectures in vitro, offering a vast potential for human disease modeling. They enable the in vitro study of human physiological and pathophysiological mechanisms of various neurological diseases and disorders.
Alexander Geidies, Marija LJ Medar, Hannes M Beyer   +2 more
openaire   +3 more sources

Characterizing Tissue Oxygen Tension During Neurogenesis in Human Cerebral Organoids

Bio-Protocol
Oxygen tension is a key regulator of early human neurogenesis; however, quantifying intra-tissue O2 in 3D models for an extended period remains difficult.
Yuan- Liu, Hsiao- Wu
doaj   +1 more source

Neuromorphic Devices and Computing for Sensing, Memory, and Control

Advanced Science, EarlyView.
This review introduces neuromorphic devices made from diverse materials. These devices mimic neuronal functions and architectures and, when integrated with artificial or biological computing, can form closed loops with neurons for pressure, optical, acoustic, and biochemical sensing and modulation.
Zhengguang Zhu, Nicholas Schaffer, Xiao Yang   +2 more
wiley   +1 more source