Results 141 to 150 of about 459,917 (239)
Energetic dysregulations in psychotic disorders: Targets for new therapeutics
The FEBS Journal, EarlyView.The present review synthesizes literature documenting aberrant energy production and use, specifically related to mitochondrial and redox dysregulation, in psychotic disorders. Findings from different levels of investigation—genetic, cellular, and in vivo imaging—converge on aberrant energy metabolism as a hallmark of psychotic disorders.
Jacey Anderson +10 more
wiley +1 more source
Engineering cerebral folding in brain organoids
Neural Regeneration Research, 2022 Glen Scott, Yu Huang
openaire +3 more sources
RLIM‐associated neurodevelopmental disorders: From clinical spectrum to molecular mechanisms
The FEBS Journal, EarlyView.RLIM (RNF12) is an E3 ubiquitin ligase essential for mammalian development. Loss‐of‐function variants cause Tønne–Kalscheuer syndrome, while duplications cause Xq13 duplication syndrome, highlighting RLIM dosage sensitivity. This review summarizes the genetics, clinical features, and molecular mechanisms of RLIM‐associated disorders, integrating ...
Madison Landon +4 more
wiley +1 more source
20th Anniversary of human‐induced pluripotent stem cells and the role of microscopy
Journal of Microscopy, EarlyView.Abstract It has been 20 years since the pioneering work of Shinya Yamanaka and Kazutoshi Takahashi at Kyoto University led to the first successful generation of induced pluripotent stem cells (iPSCs) from mouse embryonic and adult fibroblast cells. iPSCs have the capacity to differentiate into any type of cell in the human body, and as such, they have ...
Philomena Hallford +3 more
wiley +1 more source
Guía de orientación para familiares, amistades y personas que ejercen los cuidados de personas con daño cerebral adquirido [PDF]
Esta guía está dirigida a familiares, amigos y cuidadores de personas con daño cerebral. El texto ofrece indicaciones sencillas sobre las diferentes etapas en la evolución del daño cerebral desde los primeros momentos de la lesión y pretende servir de ...
Daño Cerebral Estatal
core
CellsGenome editing, notably CRISPR (cluster regularly interspaced short palindromic repeats)/Cas9 (CRISPR-associated protein 9), has revolutionized genetic engineering allowing for precise targeted modifications.
Lucia Gallego Villarejo +6 more
doaj +1 more source
Lower density of calretinin‐immunopositive neurons in the putamen of subjects with schizophrenia
Journal of Anatomy, Volume 246, Issue 4, Page 505-516, April 2025.Recent neuroimaging and histological studies highlight the striatum as a key area involved in SCH, but the specific impairment of neuronal subtypes in subcortical structures is not fully understood. This study is the first detailed investigation of neuroanatomical changes in the putamen in SCH, specifically examining the density of calretinin ...
Paz Kelmer +4 more
wiley +1 more source
Journal of Anatomy, EarlyView.A well‐preserved 20 post‐conception week human brain was obtained and finely dissected into 18 anatomically distinct regions, including the pia mater. Each region underwent in‐depth proteomic analysis, encompassing both total protein content and post‐translational modifications.
S. Bandiera +9 more
wiley +1 more source
iScienceSummary: Efforts to efficiently target brain tumors are constrained by the dearth of appropriate models to study tumor behavior toward treatment approaches as well as potential side effects to the surrounding normal tissue.
Esther Schickel +7 more
doaj +1 more source
Understanding extracellular vesicles in antiaging
Periodontology 2000, EarlyView.Abstract Background Aging is a multifactorial process marked by gradual cellular dysregulation, regulated by hallmarks, including genomic instability, mitochondrial dysregulation, and chronic inflammation. Extracellular vesicles (EVs), especially exosomes, have emerged as pivotal mediators of cell‐to‐cell communication with potential roles in both ...
Paras Ahmad +3 more
wiley +1 more source