Results 131 to 140 of about 459,917 (239)

Organoid data distributions.

, 2020
(A) Distribution of the number of manual segmentation boundary points per organoid. (B) Distribution of organoid effective diameter, defined as .
Kevin J. Cheung (8339253), Veena Padmanaban (8339247), Joel S. Bader (205554), Yohannes Tsehay (8339250), Andrew J. Ewald (8339256)   +4 more
core   +1 more source

Chronic Prostatitis/Chronic Pelvic Pain Syndrome: Research Progress and Precision Diagnosis‐Therapy Under the Integrated Neuro–Immune–Metabolic–Microbiota Axis Framework

iMetaMed, EarlyView.
Chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) is increasingly recognized as a systemic disorder rather than a purely local prostate disease. The diagram illustrates the transition from the traditional local prostate‐centered model to a multi‐axis systemic framework involving clinical heterogeneity, local prostatic inflammation, systemic ...
Kun Wang, Jinfei Liu, Qiangsheng Wang, Lei Fan, Ziang Li, Xuexin Yu, Yonghao Chen, Xiaofan Lu, Guiyi Liao, Jialin Meng, Yu Guan   +10 more
wiley   +1 more source

Toxicity Differences Between Microplastics and Nanoplastics in Organs: From Molecular Mechanisms to Potential Therapeutic Strategies

Med Research, EarlyView.
This review systematically compares the size‐dependent toxicity of microplastics and nanoplastics in the intestine, liver, kidney, lung, and brain. Particle size determines bioavailability, barrier penetration, and injury mechanisms. Because of their small size and high surface reactivity, NPs readily cross the intestinal epithelium and blood–brain ...
Yixian Cheng, Junjie Chen, Rui Fu, Jiawei Zhang, Jianguang Jia, Wei Wang, Zheng Zhang, Peng Zhang, Haosong Chen, Huake Cao, Gang Li, Weiwei Sheng, Ting Li, Bo Chen, Guodong Cao   +14 more
wiley   +1 more source

Cryopreservation of human cortical organoids using vitrification

Frontiers in Molecular Neuroscience
Vitrification is a fast-cooling cryopreservation technique that limits ice crystal formation and cryoprotectant toxicity. We adapted an established vitrification method used on oocytes and blastocysts and optimized it for the cryopreservation of single ...
Kyle Stokes, Sandra Mojica-Perez, Sandra Mojica-Perez, Samantha Jacobs, Joy Huang, Shivanshi Vaid, Shivanshi Vaid, Yukun Yuan, Caroline A. Pearson, Daniel Montes, Andrew Tidball, Andrew Tidball, Debora VanHeyningen, Jonathan Gaillard, Jonathan Gaillard, Louis T. Dang, Louis T. Dang, Louis T. Dang, Margaret Elizabeth Ross, Lori L. Isom, Lori L. Isom, Lori L. Isom, Michael Uhler, Michael Uhler, Wei Niu, Wei Niu, Wei Niu, Jack M. Parent, Jack M. Parent, Jack M. Parent, Jack M. Parent   +30 more
doaj   +1 more source

Navigating the Complexity: A Comprehensive Review of GSK‐3 Inhibition in Regenerative Medicine

Medicinal Research Reviews, EarlyView.
ABSTRACT Glycogen synthase kinase‐3 (GSK‐3) is a central regulator of numerous cellular signaling pathways, with critical roles in metabolism, proliferation, differentiation, and tissue regeneration. This review explores the multifaceted effects of pharmacological GSK‐3 inhibition across multiple body districts, focusing on its highly context‐dependent
Davide Schiroli, Alessia Merra, Chiara Marraccini, Lucia Merolle, Graziella Pellegrini, Eleonora Maurizi   +5 more
wiley   +1 more source

A tumorigenicity evaluation platform for cell therapies based on brain organoids

Translational Neurodegeneration
Background Tumorigenicity represents a critical challenge in stem cell-based therapies requiring rigorous monitoring. Conventional approaches for tumorigenicity evaluation are based on animal models and have numerous limitations.
Jun Xue, Youjun Chu, Yanwang Huang, Ming Chen, Meng Sun, Zhiqin Fan, Yonghe Wu, Liang Chen   +7 more
doaj   +1 more source

Cell‐Based Micro/Nanorobots: From Living Carriers to Living Therapeutic Specialists

SmartBot, EarlyView.
Cell‐based micro/nanorobots integrate evolutionarily acquired biological intelligence with engineered capabilities, offering new opportunities for precision medicine in vivo. However, the complex physiological environments of different organs pose significant challenges to their clinical translation.
Junfeng Wu, Zhaoyu Zhang, Ke Xu, Enkuo Li, Yuting Cui, Yuting Zhou, Huanyu Zhou, Beipei Zhang, Shuai Jiang, Xiaodong Wang, Jialin Jiang, Lianqing Liu, Niandong Jiao   +12 more
wiley   +1 more source

Advances and Challenges in Cerebral Organoids Research

Advanced NanoBiomed Research
Cerebral organoids are three‐dimensional (3D) aggregates with a more advanced composition, maturation, and architecture. It has emerged as a novel and sophisticated model system for studying neurodevelopment and neurological disorders, in comparison to ...
Dandan Luo, Jiaqi Xu, Fuyao Liu, Zhen Gu
doaj   +1 more source

Challenges in Gene‐Directed Therapies for Rare Neurodevelopmental Disorders Using HNRNPU as an Exemplar

Clinical Genetics, EarlyView.
Beyond diagnosing rare neurodevelopmental disorders like HNRNPU‐RNDD, developing gene‐directed therapies requires overcoming complex hurdles, including spatial, developmental, and cell‐type constraints. Addressing these requires understanding the molecular effects of dosage and chromatin dynamics to deliver precise, effective treatments.
Daniel Aiyedun, Susan F. Rogers, Doaa M. Taha, Meena Balasubramanian   +3 more
wiley   +1 more source

Applications of multiphoton microscopy in imaging cerebral and retinal organoids

Frontiers in Neuroscience
Cerebral organoids, self-organizing structures with increased cellular diversity and longevity, have addressed shortcomings in mimicking human brain complexity and architecture.
Macit Emre Lacin, Murat Yildirim
doaj   +1 more source