Results 51 to 60 of about 100,816 (310)

PTENP1 is a ceRNA for PTEN: it’s CRISPR clear [PDF]

Journal of Hematology & Oncology, 2020
AbstractHere we apply state-of-the-art CRISPR technologies to study the impact that PTENP1 pseudogene transcript has on the expression levels of its parental gene PTEN, and hence on the output of AKT signaling in cancer. Our data expand the repertoire of approaches that can be used to dissect competing endogenous RNA (ceRNA)-based interactions, while ...
Leonardo Salmena, Leonardo Salmena, Monica Evangelista, Marianna Vitiello, Pier Paolo Pandolfi, Pier Paolo Pandolfi, Pier Paolo Pandolfi, Laura Poliseno, Yang Zhang   +8 more
openaire   +7 more sources

MicroRNAs-mediated heat stress regulations in plants: Mechanisms and targets. [PDF]

Plant Genome
Abstract Heat stress, exacerbated by global warming, can cause significant challenges to agriculture, adversely impacting plant growth, reproduction, and yield. This review examines the crucial role of microRNAs (miRNAs) in mediating plant responses to heat stress across various key crops, including Arabidopsis (Arabidopsis thaliana), rice (Oryza ...
Farooq M, Tanveer H, Rehman HM, Cheema RA, Nawaz S, Ijaz A, Arif M, Lam HM.   +7 more
europepmc   +2 more sources

Integrated Analysis of circRNA-miRNA-mRNA ceRNA Network in Cardiac Hypertrophy

Frontiers in Genetics, 2022
Cardiac hypertrophy is an adaptive cardiac response that accommodates the variable hemodynamic demands of the human body during extended periods of preload or afterload increase.
Yangfeng Chen, Ling-Feng Zhong, Xia Hong, Qian-li Zhu, Songduo Wang, Ji-Bo Han, Wei‐Jian Huang, Bo Ye   +7 more
semanticscholar   +1 more source

Optimal Control of MDPs with Temporal Logic Constraints [PDF]

, 2013
In this paper, we focus on formal synthesis of control policies for finite Markov decision processes with non-negative real-valued costs. We develop an algorithm to automatically generate a policy that guarantees the satisfaction of a correctness ...
Belta, Calin, Cerna, Ivana, Svorenova, Maria   +2 more
core   +1 more source

Prognostic Roles of ceRNA Network-Based Signatures in Gastrointestinal Cancers

Frontiers in Oncology, 2022
Gastrointestinal cancers (GICs) are high-incidence malignant tumors that seriously threaten human health around the world. Their complexity and heterogeneity make the classic staging system insufficient to guide patient management.
Xin Qi, Xingqi Chen, Yuanchun Zhao, Jiajia Chen, Beifang Niu, Bairong Shen   +5 more
semanticscholar   +1 more source

Analysis of a circRNA-, miRNA-, and mRNA-associated ceRNA network reveals potential biomarkers in preeclampsia a ceRNA network in preeclampsia [PDF]

Annals of Medicine, 2021
Preeclampsia (PE), one of hypertension-related disorders of pregnancy, is a common cause of maternal death worldwide. This study aimed to identify a circRNA-miRNA-mRNA-associated ceRNA network and related pathways in PE. We downloaded 3 microarray datasets from the Gene Expression Omnibus database, obtained 163 differentially expressed circRNAs (dif ...
Xiaoxiao Xu, Sha Lv, Ziwen Xiao
openaire   +3 more sources

Identification of circular RNA expression profiles in renal fibrosis induced by obstructive injury

Renal Failure, 2021
Introduction Advancing renal fibrosis is the common histopathological feature of chronic obstructive nephropathy, representing the final pathway of nearly all chronic and progressive nephropathies.
Jiangju Huang, Zhihao Zhang, Benquan Liu, Ying Gao, Jiayi Nie, Shihong Wen, Xiaohong Lai, Hua Liang   +7 more
doaj   +1 more source

LncRNAs in Ovarian Cancer Progression, Metastasis, and Main Pathways: ceRNA and Alternative Mechanisms

International Journal of Molecular Sciences, 2020
Ovarian cancer (OvCa) develops asymptomatically until it reaches the advanced stages with metastasis, chemoresistance, and poor prognosis. Our review focuses on the analysis of regulatory long non-coding RNAs (lncRNAs) competing with protein-coding mRNAs
E. Braga, M. Fridman, A. A. Moscovtsev, E. Filippova, A. Dmitriev, N. Kushlinskii   +5 more
semanticscholar   +1 more source

Interactions between Distant ceRNAs in Regulatory Networks [PDF]

Biophysical Journal, 2014
Competing endogenous RNAs (ceRNAs) were recently introduced as RNA transcripts that affect each other's expression level through competition for their microRNA (miRNA) coregulators. This stems from the bidirectional effects between miRNAs and their target RNAs, where a change in the expression level of one target affects the level of the miRNA ...
Mor Nitzan, Avital Steiman-Shimony, Yael Altuvia, Ofer Biham, Hanah Margalit   +4 more
openaire   +4 more sources

The ceRNA network of lncRNA and miRNA in lung cancer [PDF]

Genomics & Informatics, 2020
Since lung cancer is a major causative for cancer-related deaths, the investigations for discovering biomarkers to diagnose at an early stage and to apply therapeutic strategies have been continuously conducted. Recently, long non-coding RNAs (lncRNAs) and microRNAs (miRNAs) are being exponentially studied as promising biomarkers of lung cancer ...
Wanyeon Kim, Dain Kim, Danbi Seo, Yeonsoo Chae   +3 more
openaire   +3 more sources