Results 81 to 90 of about 100,816 (310)

SenExo‐cCCT2 Reprograms Senescence Response and Anti‐Tumor Immunity Following FOLFIRINOX Chemotherapy in Pancreatic Ductal Adenocarcinoma

Advanced Science, EarlyView.
This study demonstrates that SenExo‐cCCT2 enables targeted delivery of cCCT2 to pancreatic cancer cells, where it disrupts IPO13‐mediated nuclear translocation of UBC9, impairing SUMOylation‐dependent DNA damage repair and inducing senescence. Senescent tumor cells secrete CXCL10 to recruit CD8⁺ T‐cells while upregulating PD‐L1.
Shuncang Zhu, Yinhao Chen, Hongyi Lin, Jinpeng Lu, Yu Pan, Ge Li, Yongding Wu, Haoxiang Zhang, Xiaoxiao Huang, Yiting Chen, Huangjing Chen, Long Jin, Min Huang, Chengyu Liao, Long Huang, Yifeng Tian, Zuwei Wang, Qiaowei Li, Shi Chen   +18 more
wiley   +1 more source

Integrated Analysis of lncRNA–Mediated ceRNA Network in Lung Adenocarcinoma

Frontiers in Oncology, 2020
Background A growing body of evidence indicates that long non-coding RNAs (lncRNAs) can act as competitive endogenous RNAs (ceRNAs) to bind to microRNAs (miRNAs), thereby affecting and regulating the expression of target genes.
Xian-xian Wu, Zhi-lin Sui, Hongdian Zhang, Ying Wang, Zhentao Yu   +4 more
semanticscholar   +1 more source

Identifying Autophagy-Related lncRNAs and Potential ceRNA Networks in NAFLD

Frontiers in Genetics, 2022
Nonalcoholic fatty liver disease (NAFLD) is a common chronic disease with complex pathogenesis, which brings economic burden to the society, and there is still no effective therapy. Impaired autophagy has been implicated in the development of NAFLD. Long
Ziyi Cao, Lina Guan, Ru Yu, Jie Chen
semanticscholar   +1 more source

Hsa_circ_0026782 Acts as a “Molecular Break” of CREB1‐Mediated Transcription by Promoting Its Phosphorylation at Ser142 That Prevents Keloid Progression

Advanced Science, EarlyView.
Model for the role of hsa_circ_0026782/p‐CREB1 (Ser142) played in keloid. Hsa_circ_0026782 is derived from back‐splicing of ITGA7 exon 4. When hsa_circ_0026782 binds to CREB1, the exposure of the bZIP domain and dimerization of CREB1 are promoted (upper left).
Xin‐Cao Zhong, Chun‐Ye Chen, Zi‐Xuan Feng, Yong Wang, Tao Zhang, Ze‐Ming Zhuang, Zhang‐Rui Wu, Yong‐Zhong Du, Jun Chen, Xiao‐Ying Lin, Wei‐Qiang Tan   +10 more
wiley   +1 more source

Circular RNA Circ-ZNF609 Promotes Lung Adenocarcinoma Proliferation by Modulating miR-1224-3p/ETV1 Signaling

Cancer Management and Research, 2020
Yangsong Zuo,1,* Wenyi Shen,1,* Chengshi Wang,1,* Niu Niu,2,* Juan Pu1 1Department of Radiation, Lianshui People’s Hospital Affiliated to Kangda College of Nanjing Medical University, Huai’an, People’s Republic of China; 2Cancer ...
Zuo Y, Shen W, Wang C, Niu N, Pu J
doaj  

Cucurbitacin B regulates lung cancer cell proliferation and apoptosis via inhibiting the IL-6/STAT3 pathway through the lncRNA XIST/miR-let-7c axis

Pharmaceutical Biology, 2022
Context Lung cancer, the most common type of cancer, has a high mortality rate. Cucurbitacin B (CuB), a natural compound extracted from Cucurbitaceae plants, has antitumor effects.
Jian-Hua Liu, Chen Li, Liang Cao, Chang-Hong Zhang, Zhi-Hua Zhang   +4 more
doaj   +1 more source

lncRNA ZFAS1 promotes lung fibroblast-to-myofibroblast transition and ferroptosis via functioning as a ceRNA through miR-150-5p/SLC38A1 axis

Aging, 2020
Pulmonary fibrosis (PF) is a lethal fibrotic lung disease. The role of lncRNAs in multiple diseases has been confirmed, but the role and mechanism of lncRNA zinc finger antisense 1 (ZFAS1) in the progression of PF need to be elucidated further.
Yanni Yang, W. Tai, Nihong Lu, Ting Li, Yongjun Liu, Wenjuang Wu, Zhengkun Li, Lin Pu, Xiaoyuan Zhao, Tao Zhang, Zhaoxing Dong   +10 more
semanticscholar   +1 more source

Identification of ferroptosis‐related genes involved in chronic obstructive pulmonary disease based on bioinformatics analysis

Animal Models and Experimental Medicine, EarlyView.
The design of the entire paper. Green part represents the bioinformatics analysis approach. Yellow part represents the ideas of animal experiment. Abstract Background Chronic obstructive pulmonary disease (COPD) is a type of chronic respiratory disease.
Xuejing Luan, Jinghui Xie, Lu Zhang, Xiao Ma, Lichangtian Jiao, Jie Zhu   +5 more
wiley   +1 more source

Research progress of long non-coding RNA in cutaneous squamous cell carcinoma

Pifu-xingbing zhenliaoxue zazhi, 2022
Cutaneous squamous cell carcinoma (cSCC) is one of the most common types of skin cancer. The incidence of the skin cancer is increasing year by year and seriously affects the quality of life of patients.
Xianwen LI, Ju WEN, Si QIN, Rongchang ZHENG, Huarun LI, Zhenyu LU, Mujin LI, Sihui LI   +7 more
doaj   +1 more source

NILAI CERNA PROTEIN IN VITRO DAN ORGANOLEPTIK MP-ASI BISKUIT BAYI DENGAN SUBSTITUSI TEPUNG KEDELAI, TEPUNG UBI JALAR KUNING DAN PATI GARUT [PDF]

, 2013
Latar Belakang: MP-ASI biskuit bayi perlu diberikan pada bayi diatas 6 bulan untuk melatih ketrampilan mengunyah. Bahan pangan lokal dapat digunakan untuk menghasilkan biskuit yang mengandung protein tinggi.
Rustanti, Ninik, Zulfa, Nur Ilaika
core   +1 more source