Results 31 to 40 of about 17,535 (240)
Identifying circRNA-associated-ceRNA networks in juvenile spondyloarthropathies patients
Pediatric Rheumatology, 2023 Abstract Background Juvenile spondyloarthropathies (JSpA) are defined as a heterogeneous group of diseases that start before the age of 16. The study aimed to identify key genes and pathways that are influenced by circRNAs and to screen potential therapeutic agents for JSpA.
Wei Qijiao +4 more
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BMC Medical Genomics, 2022 Research Highlights It was the first time to explore the disorder of ceRNA network involved in the pathogenesis of AIH. The co-expression relationship between the differentially expressed lncRNAs, miRNAs and mRNAs were predicted. The potential biological
Zhencheng Li +6 more
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Frontiers in Genetics, 2021 ObjectiveAcute lymphoblastic leukemia (ALL) is a malignant disease most commonly diagnosed in adolescents and young adults. This study aimed to explore potential signatures and their functions for ALL.MethodsDifferentially expressed mRNAs (DEmRNAs) and ...
Weimin Wang +6 more
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Construction and dissection of the ceRNA‑ceRNA network reveals critical modules in depression
Molecular Medicine Reports, 2019 The prevalence of mental health disorders such as depression is high. Depression is a multifactorial disorder and its underlying mechanisms remain unclear. Competing endogenous RNA (ceRNA) regulation has been reported to serve important roles in human disease.
Lang, Yan, Zhang, Jingchao, Yuan, Zheng
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Regulation of Long Non-coding RNA KCNQ1OT1 Network in Colorectal Cancer Immunity
Frontiers in Genetics, 2021 Over the past few decades, researchers have become aware of the importance of non-coding RNA, which makes up the vast majority of the transcriptome.
Junjie Liu +3 more
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Construction of a ceRNA Network Related to Rheumatoid Arthritis
Genes, 2022 (1) Background: Rheumatoid arthritis (RA) is a common systemic autoimmune disease affecting many people and has an unclear and complicated physiological mechanism. The competing endogenous RNA (ceRNA) network plays an essential role in the development and occurrence of various human physiological processes. This study aimed to construct a ceRNA network
Huang, Zhanya, Kuang, Nanzhen
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High-throughput validation of ceRNA regulatory networks
BMC Genomics, 2017 Background: MicroRNAs (miRNAs) play multiple roles in tumor biology [1]. Interestingly, reports from multiple groups suggest that miRNA targets may be coupled through competitive stoichiometric sequestration [2]. Specifically, computational models predicted [3, 4] and experimental assays confirmed [5, 6] that miRNA activity is dependent on miRNA target
Hua-Sheng Chiu +7 more
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Integrative Clustering Reveals a Novel Subtype of Soft Tissue Sarcoma With Poor Prognosis
Frontiers in Genetics, 2020 BackgroundSoft tissue sarcomas (STSs) are heterogeneous at the clinical and molecular level and need to be further sub-clustered for treatment and prognosis.Materials And MethodsSTSs were sub-clustered based on RNAseq and miRNAseq data extracted from The
Zhenhua Zhu +4 more
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The ceRNA network of lncRNA and miRNA in lung cancer [PDF]
Genomics & Informatics, 2020 Since lung cancer is a major causative for cancer-related deaths, the investigations for discovering biomarkers to diagnose at an early stage and to apply therapeutic strategies have been continuously conducted. Recently, long non-coding RNAs (lncRNAs) and microRNAs (miRNAs) are being exponentially studied as promising biomarkers of lung cancer ...
Seo, Danbi +3 more
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Frontiers in Bioengineering and Biotechnology, 2019 Alzheimer's disease (AD), a degenerative disease of the central nervous system, is the most common form of dementia in old age. The complexity and behavior of circular RNA (circRNA)-associated competing endogenous RNA (ceRNA) network remained poorly ...
Yan Zhang, Fulong Yu, Siqi Bao, Jie Sun
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