Results 61 to 70 of about 17,535 (240)

Comprehensive Construction of a Circular RNA-Associated Competing Endogenous RNA Network Identified Novel Circular RNAs in Hypertrophic Cardiomyopathy by Integrated Analysis

Frontiers in Genetics, 2020
Hypertrophic cardiomyopathy (HCM), the most common heritable cardiomyopathy, is associated with a high risk of sudden cardiac death. The complexity and behavior of the circular RNA (circRNA)-associated competing endogenous RNA (ceRNA) network in HCM have
Qi Guo, Qi Guo, Junjie Wang, Junjie Wang, Runlu Sun, Runlu Sun, Zhijian He, Zhijian He, Qian Chen, Qian Chen, Wenhao Liu, Wenhao Liu, Maoxiong Wu, Maoxiong Wu, Jinlan Bao, Jinlan Bao, Zhaoyu Liu, Zhaoyu Liu, Jingfeng Wang, Jingfeng Wang, Yuling Zhang, Yuling Zhang   +21 more
doaj   +1 more source

A Unique Chimeric RNA: ERCC1‐iASPP Drives Benzo[a]pyrene‐Induced Lung Carcinogenesis via Dual Coding and Non‐Coding Mechanisms

Advanced Science, EarlyView.
The chimeric RNA ERCC1‐iASPP possesses dual coding and non‐coding functions, synergistically accelerating the process of cellular malignant transformation. Abstract Genetic variation at 19q13.3 critically modulates chemical carcinogen‐induced lung carcinogenesis, particularly in mediating the activity of benzo[a]pyrene (B[a]P), a major polycyclic ...
Mingming Shan, Mingyang Xiao, Liang Zhang, Shen Wang, Jiahang Wu, Kang Cao, Yujin Li, Guopei Zhang, Junwei Xie, Xiaobo Lu   +9 more
wiley   +1 more source

A ceRNA network mediated by LINC00475 in papillary thyroid carcinoma

Open Medicine, 2021
Abstract Papillary thyroid carcinoma (PTC) is the most frequent histological type of differentiated thyroid carcinoma. Long noncoding RNAs (lncRNAs) have been widely reported to play a key role in human malignancies, and PTC is included. This study aimed to find out the functions and mechanism of lncRNA LINC00475 in PTC.
Yang Yarong, Hua Wenjuan, Zeng Mei, Yu Liling, Zhang Baijun, Wen Liming   +5 more
openaire   +3 more sources

Integrated Analysis of lncRNA–Mediated ceRNA Network in Lung Adenocarcinoma [PDF]

Frontiers in Oncology, 2020
A growing body of evidence indicates that long non-coding RNAs (lncRNAs) can act as competitive endogenous RNAs (ceRNAs) to bind to microRNAs (miRNAs), thereby affecting and regulating the expression of target genes. The lncRNA-miRNA-mRNA ceRNA network has been theorized to play an indispensable role in many types of tumors.
Xianxian Wu, Zhilin Sui, Hongdian Zhang, Ying Wang, Zhentao Yu   +4 more
openaire   +3 more sources

Construction of a lncRNA-associated competing endogenous RNA regulatory network after traumatic brain injury in mouse

Molecular Brain, 2022
Traumatic brain injury (TBI) is a major public health problem worldwide which causes high mortality and disability. Functioning as microRNA (miRNA) sponges, long non-coding RNA (lncRNA) regulates the expression of protein-coding genes in a competing ...
Siqi Wang, Yiyu Sun, Shaobo Hu, Cen Lou, Yuan-Bo Pan   +4 more
doaj   +1 more source

The Evolutionarily Conserved TPM1 Super‐Enhancer Drives Skeletal Muscle Regeneration via Mechanotransduction Signaling

Advanced Science, EarlyView.
By integrating biomechanical and epigenetic cues, the evolutionarily conserved TPM1 super‐enhancer drives myogenesis via TEAD4‐mediated chromatin looping. This mechanism produces species‐specific outputs (linear TPM1 mRNA in mice and CircTPM1 in bovine) that activate PI3K/AKT mechanotransduction and the MYH10/MYL3 axis to execute cytoskeletal ...
Ruimen Zhang, Wanyou Feng, Yanyan Yang, Yu Pan, Chaoxia Zou, Leyi Wang, Sanbao Zhang, Yimin Zhao, Yongmei Wu, Jinling Wang, Jianwei Zou, Kehe Cen, Yongwang Zhang, Han Huang, Yurong Xu, Li Zhong, Hailong Gong, Juanru Cheng, Jingyuan Liang, Zihua Zheng, Qinyang Jiang, Jingwei Wei, Hui Li, Minhui Liang, Deshun Shi, Sufang Yang, Yanfei Deng, Yingming Wei   +27 more
wiley   +1 more source

JAMI: fast computation of conditional mutual information for ceRNA network analysis [PDF]

Bioinformatics, 2018
Abstract Motivation Genome-wide measurements of paired miRNA and gene expression data have enabled the prediction of competing endogenous RNAs (ceRNAs). It has been shown that the sponge effect mediated by protein-coding as well as non-coding ceRNAs can play an important regulatory role in the cell in
Andrea Hornakova, Markus List, Jilles Vreeken, Marcel H Schulz   +3 more
openaire   +3 more sources

Integrated analysis of circRNA-associated ceRNA network in ischemic stroke

Frontiers in Genetics, 2023
Introduction: Stroke, of which ischemic stroke (IS) is the major type, is the second leading cause of disability and death worldwide. Circular RNAs (circRNAs) are reported to play important role in the physiology and pathology of IS. CircRNAs often act as competing endogenous RNA (ceRNA) to regulate gene expression by acting as miRNA sponges.
Rongli Fan, Die Hu, Maiqiu Wang, Huilin Zheng, Yifeng Zhou, Lei Zhang, Lei Zhang   +6 more
openaire   +3 more sources

Identification of ferroptosis‐related genes involved in chronic obstructive pulmonary disease based on bioinformatics analysis

Animal Models and Experimental Medicine, EarlyView.
The design of the entire paper. Green part represents the bioinformatics analysis approach. Yellow part represents the ideas of animal experiment. Abstract Background Chronic obstructive pulmonary disease (COPD) is a type of chronic respiratory disease.
Xuejing Luan, Jinghui Xie, Lu Zhang, Xiao Ma, Lichangtian Jiao, Jie Zhu   +5 more
wiley   +1 more source

Bioinformatics Analysis of ceRNA Network Related to Polycystic Ovarian Syndrome

Computational and Mathematical Methods in Medicine, 2021
Introduction. Polycystic ovary syndrome (PCOS) is caused by the hormonal environment in utero, abnormal metabolism, and genetics, and it is common in women of childbearing age. A large number of studies have reported that lncRNA is important to the biological process of cancer and can be used as a potential prognostic biomarker.
Yuanqi Li, Yong Tan
openaire   +2 more sources