Results 81 to 90 of about 17,535 (240)
Identification of lncRNA–miRNA–mRNA regulatory network associated with primary open angle glaucoma
BMC Ophthalmology, 2020 Background Primary open angle glaucoma (POAG) is a multifactorial disorder characterized by a progressive permanent degeneration of retinal ganglion cell (RGCs) death. An increasing number of studies have suggested that long noncoding RNAs (lncRNAs) have
Minwen Zhou +3 more
doaj +1 more source
Advancing Extracellular Vesicle Research: A Review of Systems Biology and Multiomics Perspectives
PROTEOMICS, EarlyView.ABSTRACT Extracellular vesicles (EVs) are membrane‐bound vesicles secreted by various cell types into the extracellular space and play a role in intercellular communication. Their molecular cargo varies depending on the cell of origin and its functional state.
Gloria Kemunto +2 more
wiley +1 more source
The ceRNA network regulates epithelial-mesenchymal transition in colorectal cancer
Heliyon, 2023 Epithelial-mesenchymal transition (EMT) is a biological process that transforms epithelial cells into a mesenchymal phenotype, conferring cell migration and invasion capabilities. EMT is involved in the progression and metastasis of colorectal cancer (CRC). Recently, emerging evidence has shown dysregulation of non-coding RNA (ncRNA) was linked to EMT.
Ruina Li, Hui Xu, Xiaoling Gao
openaire +3 more sources
Cell Proliferation, EarlyView.Non‐coding RNAs (ncRNAs) regulate breast cancer radioresistance via cell cycle, DNA repair and tumour microenvironment pathways. Targeting ncRNAs (e.g., HOTAIR and miR‐155) with RNA‐based therapies (ASOs and CRISPR) shows promise but faces delivery challenges.
Xiaohui Zhao +8 more
wiley +1 more source
Chemoresistance Mediated by ceRNA Networks Associated With the PVT1 Locus [PDF]
Frontiers in Oncology, 2019 Competitive endogenous RNA (ceRNA) networks have emerged as critical regulators of carcinogenesis. Their activity is mediated by various non-coding RNAs (ncRNAs), including long non-coding RNAs and microRNAs, which competitively bind to targets, thereby modulating gene expression and activity of proteins.
Olorunseun O. Ogunwobi +2 more
openaire +3 more sources
BMC Genomics, 2019 Background A long noncoding RNA (lncRNA) can act as a competing endogenous RNA (ceRNA) to compete with an mRNA for binding to the same miRNA. Such an interplay between the lncRNA, miRNA, and mRNA is called a ceRNA crosstalk. As an miRNA may have multiple
Chaowang Lan +3 more
doaj +1 more source
Expression profile of circular RNAs in type 2 diabetes mellitus patients with retinopathy
Journal of Diabetes Investigation, EarlyView.ABSTRACT Aims/Introduction Diabetic retinopathy (DR) is a prevalent chronic complication of type 2 diabetes mellitus (T2DM), contributing significantly to vision impairment. Circular RNAs (circRNAs) have emerged as key regulators in the pathogenesis of DR.
Wencheng An +9 more
wiley +1 more source
The exposomal imprint on rosacea: More than skin deep
Journal of the European Academy of Dermatology and Venereology, EarlyView.Rosacea reflects systemic and environmental interactions, not just a skin disorder. Key factors include environmental triggers, genetic and microbiome influences, diagnostic gaps in skin of colour and social determinants. Advances in multi‐omics and exposome integration highlight pathways towards precision medicine, prevention and equitable, patient ...
Katerina Grafanaki +3 more
wiley +1 more source
Comprehensive analysis of a cuproptosis-related ceRNA network implicates a potential endocrine therapy resistance mechanism in ER-positive breast cancer [PDF]
, 2023 Dongni Zhang +5 more
openalex +1 more source