Results 141 to 150 of about 1,781 (177)

1-Deoxysphingolipids require very-long-chain ceramide synthesis to induce ER stress and cytotoxicity. [PDF]

J Biol Chem
Byrnes C, Clarke BA, Zhu H, Lee YT, Majumder S, Kono M, Proia RL.   +6 more
europepmc   +1 more source

Oral administration of the probiotic strain <i>Lactobacillus helveticus</i> BGRA43 reduces high-fat diet-induced hepatic steatosis in mice and restores gut microbiota composition. [PDF]

Front Pharmacol
Teofilović A, Vratarić M, Bursać B, Gligorovska L, Vojnović Milutinović D, Stanisavljević N, Strahinić I, Mišić D, Nikolić F, Pavlović B, Jončić Savić K, Aydogan C, Djordjevic A.   +12 more
europepmc   +1 more source

Sphingolipid metabolism dysregulation: A cause for lung cancer development, progression, and resistance to therapies. [PDF]

Chin Med J Pulm Crit Care Med
Mao C.
europepmc   +1 more source

Fasting the mitochondria to prevent neurodegeneration: the role of ceramides. [PDF]

Front Neurosci
Valenzuela-Ahumada LA, Mercado-Gómez OF, Viveros-Contreras R, Guevara-Guzmán R, Camacho-Morales A.   +4 more
europepmc   +1 more source

Sphingolipid homeostasis and dysregulation in liver function and disease. [PDF]

Life Metab
Lan J, Pan Z, Dong W, Wang J, Zhang C, Zhang Y, Wu Y, Jin J.   +7 more
europepmc   +1 more source

CEBPγ facilitates lamellipodia formation and cancer cell migration through CERS6 upregulation

CEBPγ facilitates lamellipodia formation and cancer cell migration through CERS6 upregulation
openaire   +1 more source

LASP1, CERS6, and Actin Form a Ternary Complex That Promotes Cancer Cell Migration

Cancers, 2023
CERS6 is associated with metastasis and poor prognosis in non-small cell lung cancer (NSCLC) patients through d18:1/C16:0 ceramide (C16 ceramide)-mediated cell migration, though the detailed mechanism has not been elucidated. In the present study, examinations including co-immunoprecipitation, liquid chromatography, and tandem mass spectrometry ...
Yasuyoshi Mizutani, Keiko Kano, Motoshi Suzuki   +2 more
exaly   +4 more sources

CerS6-Derived Sphingolipids Interact with Mff and Promote Mitochondrial Fragmentation in Obesity [PDF]

Cell, 2019
Ectopic lipid deposition and altered mitochondrial dynamics contribute to the development of obesity and insulin resistance. However, the mechanistic link between these processes remained unclear. Here we demonstrate that the C16:0 sphingolipid synthesizing ceramide synthases, CerS5 and CerS6, affect distinct sphingolipid pools and that abrogation of ...
Marcus Krüger, Jens Claus Brüning, Mathias J Gerl   +2 more
exaly   +6 more sources

CerS6 Is a Novel Transcriptional Target of p53 Protein Activated by Non-genotoxic Stress* [PDF]

Journal of Biological Chemistry, 2016
Our previous study suggested that ceramide synthase 6 (CerS6), an enzyme in sphingolipid biosynthesis, is regulated by p53: CerS6 was elevated in several cell lines in response to transient expression of p53 or in response to folate stress, which is known to activate p53.
Besim Ogretmen, Sergey A Krupenko, Natalia I Krupenko   +2 more
exaly   +5 more sources