Results 151 to 160 of about 1,781 (177)

Obesity-Induced CerS6-Dependent C16:0 Ceramide Production Promotes Weight Gain and Glucose Intolerance [PDF]

Cell Metabolism, 2014
Ceramides increase during obesity and promote insulin resistance. Ceramides vary in acyl-chain lengths from C14:0 to C30:0 and are synthesized by six ceramide synthase enzymes (CerS1-6). It remains unresolved whether obesity-associated alterations of specific CerSs and their defined acyl-chain length ceramides contribute to the manifestation of ...
Jan Mauer, Arnaud Mourier, Aleksandra Trifunovic   +2 more
exaly   +7 more sources

CEBPγ facilitates lamellipodia formation and cancer cell migration through CERS6 upregulation [PDF]

Cancer Science, 2021
AbstractCeramide synthase 6 (CERS6) promotes lung cancer metastasis by stimulating cancer cell migration. To examine the underlying mechanisms, we performed luciferase analysis of the CERS6 promoter region and identified the Y‐box as a cis‐acting element.
Yasuyoshi Mizutani, Ken-Ichi Inada, Toyofumi F Chen-Yoshikawa   +2 more
exaly   +3 more sources

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AKT1/FOXP3 axis-mediated expression of CerS6 promotes p53 mutant pancreatic tumorigenesis

Cancer Letters, 2021
Ceramide synthases (CerSs) catalyze the formation of ceramides from sphingoid bases and acyl-CoA substrates. Increasing evidence suggests that cancer cells generally exhibit altered sphingolipid metabolism in the tumorigenesis of multiple cancers. However, there is no evidence that CerSs are associated with pancreatic ductal carcinoma (PDAC).
Dachuan Qi, Zhiqi Zhang, Xue Chunhua
exaly   +3 more sources

Disruption of CerS6-mediated sphingolipid metabolism by FTO deficiency aggravates ulcerative colitis

Gut, 2023
Background and aims Deregulation of RNA N6-methyladenosine (m 6 A) modification in intestinal epithelial cells (IECs) influences intestinal immune cells and leads to intestinal inflammation.
Yanru Ma, Xinyu Zhang, Baoqin Xuan, Danjie Li, Nan Yin, Lijun Ning, Yi-Lu Zhou, Yuqing Yan, Tianying Tong, Xiaoqiang Zhu, Xiaowen Huang, Muni Hu, Zhenhua Wang, Zhe Cui, Huabin Li, Jiqiu Wang, Jing-Yuan Fang, Ruixin Liu, Haoyan Chen, Jie Hong   +19 more
openaire   +2 more sources

CerS6 regulates cisplatin resistance in oral squamous cell carcinoma by altering mitochondrial fission and autophagy

Journal of Cellular Physiology, 2018
Chemoresistance remains a challenge in the effective treatment of solid tumors, including oral squamous cell carcinoma (OSCC). Mitochondrial dynamics and autophagy have recently been implicated in the chemoresistance of cancer cells. The neutralization of ceramide is also associated with multidrug resistance, and ceramide synthase 6 (CerS6) is known to
Shengjiao Li, Zexin Ai, Yunpeng Ding
exaly   +3 more sources

The role of lncRNA CERS6-AS1 in cancer and its molecular mechanisms: A systematic review and meta-analysis

Pathology - Research and Practice, 2023
LncRNAs have the potential to play a regulatory role in different processes of cancer development and progression. We conducted a systematic review and meta-analysis of evidence on the clinical significance and prognostic value of lncRNA CERS6-AS1 in cancer.This systematic review was conducted following PRISMA guidelines.
Hadith, Rastad, Parham, Samimisedeh, Mahin Seifi, Alan, Elmira Jafari, Afshar, Jamileh, Ghalami, Maryam, Hashemnejad, Mahnaz Seifi, Alan   +6 more
openaire   +2 more sources

CERS6 antisense RNA 1 promotes colon cancer via upregulating mitochondrial calcium uniporter

European Journal of Clinical Investigation, 2023
AbstractBackgroundColon cancer (CC) belongs to a common cancer of digestive system. Long non‐coding RNAs (lncRNAs) are dysregulated in numerous cancers and affect their development. The function of lncRNA CERS6 antisense RNA 1 (CERS6‐AS1) in CC remains unclear.Materials and MethodsCERS6‐AS1 expression in colon adenocarcinoma tissues and CC cell lines ...
Juan Yu, Xiaoguang Chen, Jing Li, Furang Wang   +3 more
openaire   +2 more sources

Danhe granule ameliorates nonalcoholic steatohepatitis and fibrosis in rats by inhibiting ceramide de novo synthesis related to CerS6 and CerK

Journal of Ethnopharmacology, 2022
Danhe granule (DHG) is used by Chinese doctors to treat blood stasis, phlegm and dampness. Its lipid-lowering ability has been investigated in our previous research. However, the anti-liver inflammatory and fibrotic effects and mechanism of action of DHG in non-alcoholic steatohepatitis (NASH) have not been explored.To evaluate the ameliorative effects
Meixia, Zhu, Zhixin, Jia, Xiaoning, Yan, Lirong, Liu, Cong, Fang, Menghan, Feng, Yihang, Dai, Yinhuan, Zhang, Hao, Wu, Beibei, Huang, Yueting, Li, Jie, Liu, Hongbin, Xiao   +12 more
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IGF2BP3 Worsens Lung Cancer through Modifying Long Non-coding RNA CERS6-AS1/microRNA-1202 Axis

Current Medicinal Chemistry, 2023
Background: Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) can epigenetically regulate lung cancer progression, but its regulatory mechanism in the disease lacks sufficient exploration. Objective: The study was conducted to probe the regulatory function of IGF2BP3 in lung cancer via modulating long non-coding RNA CERS6-AS1/microRNA ...
An, Yan, Xiaowei, Song, Bao, Liu, Kaibin, Zhu   +3 more
openaire   +2 more sources

CerS6 triggered by high glucose activating the TLR4/IKKβ pathway regulates ferroptosis of LO2 cells through mitochondrial oxidative stress

Molecular and Cellular Endocrinology, 2023
Lipid metabolism disorders and mitochondrial dysfunction contribute to the progression of diabetes and chronic liver disease (CLD). Ferroptosis, as a form of cell death centered on reactive oxygen species (ROS) accumulation and lipid peroxidation, is closely related to mitochondrial dysfunction.
Dan, Li, Ling, Tian, Ping, Nan, Jun, Zhang, Yin, Zheng, Xinxin, Jia, Yihui, Gong, Zhongming, Wu   +7 more
openaire   +2 more sources