Results 71 to 80 of about 15,331 (173)
Oligonucleotides used for CETP cloning and mutagenesis.
, 2023 The amplification oligos used for cDNA cloning is shown, with CETP start codon in bold in the forward (5’) primer. The reverse (3’) oligo removes the stop codon, and mutated bases are underlined.Åsa Schawlann Ølnes (17537519), Marianne Teigen (17537522), Trond P. Leren (14223497), Jon K. Laerdahl (7840751), Katrine Bjune (6858293), Thea Bismo Strøm (17537525) +5 morecore +1 more sourceGenetic variants in CETP increase risk of intracerebral hemorrhage [PDF]
, 2016 OBJECTIVE: In observational epidemiologic studies, higher plasma high-density lipoprotein cholesterol (HDL-C) has been associated with increased risk of intracerebral hemorrhage (ICH).Slowik, Agnieszka, James F. Meschia, Klijn, Catharina J M, Elosua, Roberto, Battey, Thomas W. K., Fernandez Cadenas, Israel, Enzinger, Christian, Anand Viswanathan, Worrall, Bradford, Peter Kraft, Carolina Soriano, Salman, Rustam Al Shahi, Steven M. Greenberg, Salman, Rustam Al-Shahi, PEZZINI, Alessandro, H. Bart Brouwers, Fernandez-Cadenas, Israel, van Nieuwenhuizen, Koen M., Roquer González, Jaume, Jagiella, Jeremiasz M., Rosand, Jonathan, Delgado, Pilar, Sekar Kathiresan, Nieuwenhuizen, Koen M., Kraft, Phillip, Carl D. Langefeld, Fernandez‐cadenas, Israel, Selim, Magdy, Cuadrado‐godia, Elisa, Roberto Elosua, Liu, Dajiang J, Anderson, Christopher, Jagiełła, Jeremiasz, Kraft, Peter, Giralt‐steinhauer, Eva, Peloso, Gina M., Reinhold Schmidt, Tirschwell, David L., Goncalo Abecasis, Joanna Pera, Schmidt, Helena, Alessandro Biffi, Biffi, Alessandro, Bart Brouwers, H., Ayres, Alison M., David L. Tirschwell, Koen M. van Nieuwenhuizen, Liu, Dajiang J., Battey, Thomas W K, Catherine L. Sudlow, Norrving, Bo, Christian Enzinger, Greenberg, Steven M., Alessandro Pezzini, Soriano Tàrraga, Carolina, Devin L. Brown, Brown, Devin L., Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya), Cuadrado Godia, Elisa, Sudlow, Catherine L., Matthew L. Flaherty, Jimenez-Conde, Jordi, Anderson, Christopher D., Hansen, Björn M., Deary, Ian J, Lindgren, Arne, Arne Lindgren, Kittner, Steven J., Jaume Roquer, Viswanathan, Anand, Andrea Morotti, Kristiina Rannikmae, Daniel Woo, Schmidt, Reinhold, Sudlow, Catherine L, Elisa Cuadrado‐Godia, Pilar Delgado, Samarasekera, Neshika, Pichler, Alexander, Sudlow, Catherine L.; id_orcid, Dajiang J. Liu, Silliman, Scott L., Falcone, Guido J., Roquer, Jaume, Israel Fernandez‐Cadenas, Goldstein, Joshua N., Christopher D. Anderson, Jonathan Rosand, Gina M. Peloso, Magdy Selim, Catharina J. M. Klijn, Słowik, Agnieszka, Pera, Joanna, Urbanik, Andrzej, Hansen, Björn M, Global Lipids Genetics Consortium, Andrzej Urbanik, Jimenez Conde, Jordi, Phuah, Chia-Ling, Cristen J. Willer, Flaherty, Matthew L., Jordi Jimenez‐Conde, Alexander Pichler, Agnieszka Slowik, Alison M. Ayres, Bradford B. Worrall, Eva Giralt‐Steinhauer, Phuah, Chia‐ling, Giralt-Steinhauer, Eva, Jimenez‐conde, Jordi, Bo Norrving, ?, ?, Kathiresan, Sekar, Rustam Al‐Shahi Salman, Waddy, Salina P., Joshua N. Goldstein, Klijn, Catharina J.M., Brouwers, H. Bart, Farid Radmanesh, Ian J. Deary, Neshika Samarasekera, Salman, Rustam Al‐shahi, Worrall, Bradford B., Deary, Ian J., Salina P. Waddy, Brouwers, H Bart, Cuadrado-Godia, Elisa, Abecasis, Goncalo, Chelsea S. Kidwell, Joan Montaner, Al-Shahi Salman, Rustam; id_orcid, Langefeld, Carl D., Scott L. Silliman, Morotti, Andrea, Willer, Cristen J., Thomas W. K. Battey, Guido J. Falcone, Rannikmae, Kristiina, Klijn, Catharina J. M., Phuah, Chia Ling, Chia‐Ling Phuah, Giralt Steinhauer, Eva, Woo, Daniel, Montaner, Joan, Kidwell, Chelsea S., Delgado Martínez, María Pilar, Björn M. Hansen, van Nieuwenhuizen, Koen M, International Stroke Genetics Consortium (ISGC), Radmanesh, Farid, Meschia, James F., Helena Schmidt, Jeremiasz M. Jagiella, Soriano, Carolina, Al-Shahi Salman, Rustam, Steven J. Kittner +155 morecore +4 more sourcesCYP2D6 Metabolizer Status and Mortality in Metoprolol Users
Clinical and Translational Science, Volume 19, Issue 9, September 2026.ABSTRACT
Numerous pharmacogenomic (PGx) associations of pharmacokinetics and pharmacodynamics of commonly prescribed medications have been reported. Yet, the evidence supporting their association on survival remains underexamined. We sought to investigate the CYP2D6‐metoprolol association and determine whether the established variability in drug ...Simon de Denus, Essaïd Oussaïd, Maxime Meloche, Antoine‐Xavier Bertrand, Grégoire Leclair, Marie‐Christyne Cyr, Martin Jutras, Marie‐Josée Gaulin, Ian Mongrain, David Busseuil, Jean‐Claude Tardif, Marie‐Pierre Dubé +11 morewiley +1 more sourceAngiopoietin‐like protein 3 complete and partial deficiency markedly accelerates apolipoprotein B48 and B100 metabolism in triglyceride‐rich lipoproteins in humans
Journal of Internal Medicine, Volume 300, Issue 3, Page 312-328, September 2026.Abstract Background
Angiopoietin‐like protein 3 (ANGPTL3) is a key circulating regulator of triglyceride metabolism and a promising pharmacological target. The physiological consequences of profound ANGPTL3 deficiency can be explored in individuals with inherited loss‐of‐function (LOF) variants, who show reduced lifetime risk of atherosclerotic ...Marcello Arca, Elias Björnson, Laura D'Erasmo, Alessia Di Costanzo, Simone Bini, Ilenia Minicocci, Daniele Tramontano, Stella Covino, Giuseppe Ciarlo, Manuela Lombardi, Sanni Söderlund, Niina Matikainen, Linda Andersson, Martin Adiels, Marja‐Riitta Taskinen, Chris J. Packard, Jan Borén +16 morewiley +1 more sourceExploring the Roles of Tuna‐Associated Acinetobacter sp. YFT067: Implications for Host Health and Metabolism
Animal Research and One Health, Volume 4, Issue 3, Page 278-292, August 2026.This study firstly isolated a tuna‐derived gut probiotic Acinetobacter seifertii YFT067. Dietary administration of YFT067 played significant roles in promoting growth performance, SCFAs production, lipid absorption, and metabolism of the host, indicating YFT067 as a promising probiotic candidate for enhancing tuna aquaculture productivity through ...Ying Zou, Hai Huang, Qiongyao Fu, Zhiyuan Lu, Zhiqiang Guo +4 morewiley +1 more sourceReconceptualizing Dyslipidemia: Diversity of Lipid Imbalances and Their Clinical Implications; A Narrative Review
Health Science Reports, Volume 9, Issue 8, August 2026.ABSTRACT Background and Aims
The traditional definition of dyslipidemia focuses on isolated lipid changes (LDL‐C, HDL‐C, triglycerides) and may not fully capture the biological complexity or clinical variability of lipid imbalances. Recent evidence challenges this narrow view, suggesting that dyslipidemia involves broader disruptions in lipid ...Ali Mansoursamaei, Amirhossein Yadegar, Fatemeh Mohammadi, Seyed Arsalan Seyedi, Soghra Rabizadeh, Sahar Karimpour Reyhan, Alireza Esteghamati, Manouchehr Nakhjavani +7 morewiley +1 more sourcePharmacokinetics, pharmacodynamics and safety of CKD-519, a CETP inhibitor, in healthy subjects
, 2016 Choon Ok Kim,1 Eun Sil Oh,2 Chungam Choi,1 Yeonjoo Kim,3 Sera Lee,4 Semi Kim,4 Min Soo Park1,5 1Department of Clinical Pharmacology, Severance Hospital, Yonsei University College of Medicine, Seoul, 2Department of Pharmaceutical Medicines and ...Choi CG, Kim S, Lee S, Kim YJ, Kim CO, Oh ES, Park MS +6 morecore