Results 141 to 150 of about 29,683 (253)
PAF Triggered Pyroptotic NETosis Aggravates Myocardial Ischemia/Reperfusion Injury
Advanced Science, Volume 13, Issue 25, 4 May 2026.Platelet activating factor (PAF) secreted by cardiomyocytes during MI/R, drives NETs formation and subsequent NETosis. PAF/NETosis signaling activation is an initiative and causal factor in driving MI/R injury. This study identifies dapagliflozin as a potent NETosis inhibitor, and demonstrates that manipulating PAF‐NETosis signal by dapagliflozin or ...
Jiawei Wu +11 more
wiley +1 more source
Clinical and Translational Medicine, Volume 16, Issue 5, May 2026.Neoadjuvant disitamab vedotin combined with camrelizumab and S‐1 achieved high pathological response rates with manageable safety in resectable HER2‐overexpressing gastric and gastroesophageal junction cancer. Longitudinal circulating tumour DNA methylation profiling enabled dynamic monitoring of molecular response during treatment.
Longgang Wang +10 more
wiley +1 more source
Cell-free DNA profiles of dermatomyositis and its potential role in discriminating phenotypes
Frontiers in ImmunologyBackgroundCell-free DNA (cfDNA) functions in the early-detection and monitoring of autoimmune diseases including systemic lupus erythematosus and rheumatoid arthritis.
Zhuang-li Tang +11 more
doaj +1 more source
Journal of Extracellular Vesicles, Volume 15, Issue 5, May 2026.Plasma sEV‐GCC2 enables early detection and prognostic stratification of lung adenocarcinoma. This multicenter study integrates biomarker validation with functional evidence, supporting sEV‐GCC2 as a clinically relevant biomarker. ABSTRACT Emerging evidence suggests that GRIP and coiled‐coil domain‐containing two enriched small extracellular vesicles ...
Byeong Hyeon Choi +11 more
wiley +1 more source
Molecular Carcinogenesis, Volume 65, Issue 5, Page 603-614, May 2026.ABSTRACT Functional DNA methylation abnormalities are a hallmark of human cancers and may be a promising biomarker for their early diagnosis. Moreover, the largest methylation differences can improve the sensitivity of noninvasive diagnoses of solid tumors.
Junsheng Zhao +6 more
wiley +1 more source
Virality versus veracity: A systematic review of TikTok information on prenatal aneuploidy testing
Pregnancy, Volume 2, Issue 3, May 2026.Abstract Objective Pregnant people are increasingly utilizing TikTok to understand medical information. However, the accuracy and reliability of this content remain largely unexamined. This study aimed to evaluate videos on prenatal aneuploidy testing by engagement, reliability, and quality, comparing results by content category and account type. Study
Ashley S. Houlihan +5 more
wiley +1 more source
Statistics in Medicine, Volume 45, Issue 10-12, May 2026.ABSTRACT Machine learning and artificial intelligence are increasingly applied to medical diagnostics and clinical decision‐making. To evaluate model performance, the F1$$ {F}_1 $$ score and its generalized form, the Fβ$$ {F}_{\beta } $$ score, are widely used as they balance precision and sensitivity.
Chih‐Yuan Hsu, Qi Liu, Yu Shyr
wiley +1 more source
Diagnostic and Prognostic Values of Bile Biomarkers for Malignant Biliary Stenosis
Liver International, Volume 46, Issue 5, May 2026.ABSTRACT Introduction Differentiating between malignant and benign biliary strictures remains a clinical challenge because current diagnostic tools have limited sensitivity. The detection of tumour‐related biomarkers directly in bile, which is in close contact with the lesion, may enhance diagnostic accuracy.
E. Gigante +9 more
wiley +1 more source
Cancer, Volume 132, Issue 8, 15 April 2026.ABSTRACT Background Cancer biobank studies can inform the natural history of cancer and possibilities for earlier detection. The authors investigated the detectability of a cell‐free DNA methylation‐based cancer signal in biobanked plasma samples from the large American Cancer Society Cancer Prevention Study 3.
Alpa V. Patel +12 more
wiley +1 more source
International Journal of Cancer, Volume 158, Issue 8, Page 2043-2050, 15 April 2026.What's New? High‐grade serous ovarian carcinoma is often diagnosed at advanced stages due to non‐specific symptoms and the lack of reliable screening methods. This proof‐of‐concept study introduces a novel TP53 mutation panel using unique molecular identifier‐based next‐generation sequencing for sensitive detection of high‐grade serous ovarian ...
Amanda Olsson Widjaja +11 more
wiley +1 more source