Results 141 to 150 of about 23,420 (253)
Circulating Tumor Cells in Multiple Myeloma: From Peripheral Clues to Central Insights
CTC offer a minimally invasive widow into systemic myeloma biology, overcoming the sampling bias of bone marrow biopsies. Their prognostic value at diagnosis, potential role in MRD monitoring, and ability to capture clonal evolution highlight them as actionable biomarkers for future precision medicine.
Benjamin Podvin +3 more
wiley +1 more source
Factors affecting cfDNA test failure (univariate analysis).
Factors affecting cfDNA test failure (univariate analysis).
Tomas Sladecek (18121408) +9 more
core +1 more source
Ischemia–Reperfusion Injury: Molecular Mechanisms and Therapeutic Interventions
Multiorgan ischemia–reperfusion injury begins with ischemia‐induced ATP depletion and ionic imbalance, followed by reperfusion‐triggered mitochondrial ROS/RNS bursts, regulated cell death, and DAMP release. Sterile inflammation converges on endothelial–immune–coagulation crosstalk, where NETs drive immunothrombosis, no‐reflow, and remote organ injury ...
Peng An +4 more
wiley +1 more source
Plasma cfDNA is highly degraded.
(A) Box blot displaying sample plasma cfDNA copies measured by real-time PCR (copies/ml) median; vertical bar, 2701 and 1406) (n = 161) for both 79 bp and 148 bp fragments, respectively and (B) a scatter plot showing a positive linear correlation (r = 0 ...
Serdar Coskun (738308) +6 more
core +1 more source
A total of 127 advanced pancreatic ductal adenocarcinoma (PDAC) patients receiving first‐line therapy were enrolled in this study. A series of peripheral blood collected before the initiation of treatment (B1), at the first response assessment (B2), and at subsequent timepoints to perform high‐depth next‐generation sequencing.
Tingting You +9 more
wiley +1 more source
Chemical and Technological Aspects of Magnetic Particles for Cancer Liquid Biopsy Applications
Magnetic bead engineering for liquid biopsy diagnostics reviews advances in magnetic bead design for the selective enrichment of circulating tumor DNA (ctDNA), circulating tumor cells (CTCs), and extracellular vesicles (EVs) from complex biofluids.
Beatriz Naranjo‐Martínez +9 more
wiley +1 more source
Abstract A substantial portion of RhD‐negative pregnant patients carry an RhD‐negative fetus and are not at risk of RhD alloimmunization. Knowing the fetal RhD genotype allows such patients to avoid unnecessary monitoring or treatment. The use of cell‐free DNA (cfDNA) to detect the fetal RhD genotype from maternal blood has been proposed to identify ...
Society for Maternal‐Fetal Medicine (SMFM) +8 more
wiley +1 more source
In patients with mCSPC treated with apalutamide plus ADT, baseline ctDNA predicted earlier progression to CRPC and worse overall survival. Exploratory genome‐wide analysis identified 12 SNPs associated with apalutamide‐related skin rash. ABSTRACT Despite promising evidence of the efficacy of the androgen deprivation therapy (ADT) plus apalutamide in ...
Masaki Shiota +8 more
wiley +1 more source
Abstract This study investigated cell‐free DNA (cfDNA) kinetics during an all‐out and 3‐h cycling protocol, focusing on sex differences. Eighteen participants (9 women, 9 men) performed a VO2max test on a cycling ergometer. One to four weeks thereafter, 17 participants completed 3‐h cycling at an intensity 5% below their first ventilatory threshold ...
Kira Enders +7 more
wiley +1 more source
DNA from neutrophil extracellular traps (NET‐DNA) restricts the function of IL‐22‐dependent ILC3s in intestinal defense through coiled‐coil domain containing protein 25 (CCDC25), which hinders the repair of intestinal epithelial cells and promotes the progression of UC.
Bo Xu +14 more
wiley +1 more source

