Results 91 to 100 of about 34,737 (190)
cGAS Regulates the Radioresistance of Human Head and Neck Squamous Cell Carcinoma Cells
Cells, 2022 Cyclic GMP-AMP synthase (cGAS) plays an important role in biological responses to pathogens. The activation of the cGAS pathway in immune cells is known to induce antitumor effects, but the role of cGAS in cancer cells remains poorly understood.
Taichi Nyui +4 more
doaj +1 more source
Galois theory for iterative connections and nonreduced Galois groups [PDF]
, 2008 This article presents a theory of modules with iterative connection. This theory is a generalisation of the theory of modules with connection in characteristic zero to modules over rings of arbitrary characteristic.
Maurischat, Andreas
core +2 more sources
The cGAS-STING Pathway in Bacterial Infection and Bacterial Immunity
Frontiers in Immunology, 2022 Cyclic guanosine monophosphate (GMP)-adenosine monophosphate (AMP) (cGAMP) synthase (cGAS), along with the adaptor stimulator of interferon genes (STING), are crucial components of the innate immune system, and their study has become a research hotspot ...
Nanxin Liu +3 more
semanticscholar +1 more source
SnapShot: CGAS-STING Signaling
Cell, 2018 CGAS responds to cytosolic DNA by initiating a STING-dependent response that ultimately engages innate immune effectors to ensure the preservation of organismal homeostasis.
Sandra Demaria +3 more
openaire +2 more sources
A Randomized Depression Prevention Trial Comparing Interpersonal Psychotherapy—Adolescent Skills Training To Group Counseling In Schools [PDF]
, 2016 Given the rise in depression disorders in adolescence, it is important to develop and study depression prevention programs for this age group. The current study examined the efficacy of Interpersonal Psychotherapy-Adolescent Skills Training (IPT-AST), a ...
Benas, J. S. +5 more
core +1 more source
Advances in Marine Sciences, 2017 环鸟苷酸-腺苷酸合成酶(cyclic GMP-AMP synthase, cGAS)是一种核酸转移酶，在哺乳动物中具有DNA 感受器的功能，能识别胞质DNA并产生cGAMP (cyclic GMP-AMP)，激活干扰素刺激蛋白(stimulator of interferon genes, STING)，调控下游的I型干扰素(interferon, IFN)和其他细胞因子的分泌，启动机体的免疫反应。cGAS不仅能够抗病毒，也能抵抗细菌的感染。结构上，cGAS由氨基端的DNA结合位点，中间的催化结构域以及羧基端保守的Mab-21 (male abnormal 21)结构域组成，属于MAB21家族蛋白。进化分析发现，脊椎动物的cGAS来源于祖先Mab-21结构域 ...
openaire +2 more sources
Neuroinflammation and the cGAS-STING pathway [PDF]
Journal of Neurophysiology, 2019 The recent discovery of cyclic GMP-AMP synthase (cGAS) as the mammalian cytosolic DNA sensor has profound therapeutic implications for infection, immunology, and cancer. Because neurovirology, neuroimmunology, neuro-oncology, and neurodegeneration implicate cytosolic DNA sensing, cGAS activation and induction of the downstream signaling protein ...
openaire +3 more sources
The multiple faces of cGAS-STING in antitumor immunity: prospects and challenges
Medical ReviewAs a key sensor of double-stranded DNA (dsDNA), cyclic GMP-AMP synthase (cGAS) detects cytosolic dsDNA and initiates the synthesis of 2′3′ cyclic GMP-AMP (cGAMP) that activates the stimulator of interferon genes (STING).
Zhou Zheqi +6 more
doaj +1 more source
Role and Mechanism of cGAS-STING Pathway in Cardiovascular System
Reviews in Cardiovascular MedicineThe cyclic guanosine monophosphate-adenosine monophosphate (GMP-AMP) synthase (cGAS)-stimulator of interferon genes (STING) pathway is a part of the innate immune system that plays a role in the cardiovascular system.
Xianqiang Yu, Silin Pan
doaj +1 more source
Airway epithelial cGAS inhibits LPS-induced acute lung injury through CREB signaling
Cell Death and Disease, 2023 Increased levels of cytosolic DNA in lung tissues play an important role in acute lung injury. However, the detailed mechanisms involved remain elusive.
Zhangchu Jin +17 more
doaj +1 more source