Results 91 to 100 of about 41,079 (213)

A TRAF3-NIK module differentially regulates DNA vs RNA pathways in innate immune signaling. [PDF]

, 2018
Detection of viral genomes by the innate immune system elicits an antiviral gene program mediated by type I interferons (IFNs). While viral RNA and DNA species induce IFN via separate pathways, the mechanisms by which these pathways are differentially ...
Aliyari, Saba Roghiyh, Chapon, Maxime, Cheng, Genhong, Dev, Anurupa, Dhingra, Anant, Gerami, Hoda, Ghaffari, Amir A, Parvatiyar, Kislay, Pindado, Jose, Zaver, Shivam A   +9 more
core  

Inhibition of Cyclic GMP-AMP Synthase Ameliorates Cardiac Dysfunction in Rats After Cardiac Arrest

Cardiovascular Innovations and Applications
Cardiac dysfunction is a prevalent and serious complication after cardiac arrest (CA), yet limited therapeutic interventions are available. Cyclic GMP-AMP synthase (cGAS), a critical mediator of innate immune responses, has recently been identified as a ...
Ruiyu Wang, Ning Zhou, Yue Luo, Xiaohong Zhang, Chuanzhu Lv   +4 more
doaj   +1 more source

Research and progress of cGAS/STING/NLRP3 signaling pathway: a mini review

Frontiers in Immunology
Over the past decade, inflammasome and cGAS-STING have received significant attention as immune components that coordinate host immune homeostasis.
Ke-qian Chen, Wen-rui Tang, Xiang Liu
doaj   +1 more source

cGAS-STING targeting offers therapy choice in lung diseases

Biology Direct
Cyclic GMP/AMP (cGAMP) synthase (cGAS), along with the endoplasmic reticulum (ER)-associated stimulator of interferon genes (STING), are crucial elements of the type 1 interferon response.
Yu Wang, Xuan Zhang, Weixue Wang, Yi Zhang, Joshua S. Fleishman, Hongquan Wang   +5 more
doaj   +1 more source

cGAS deficiency mitigated PM2.5-induced lung injury by inhibiting ferroptosis

Ecotoxicology and Environmental Safety
Ferroptosis emerges as one of the pivotal types of cell death during fine particulate matter (PM2.5)-induced lung injury. The recently discovered cytosolic DNA sensor, cyclic GMP-AMP synthase (cGAS), triggers the activation of the downstream adaptor ...
Huasong Liu, Juan Wang, Juan Xiong, Zhipeng Hu   +3 more
doaj   +1 more source

cGAS: action in the nucleus

Frontiers in Immunology
As a canonical cytoplasmic DNA sensor, cyclic GMP-AMP synthase (cGAS) plays a key role in innate immunity. In recent years, a growing number of studies have shown that cGAS can also be located in the nucleus and plays new functions such as regulating DNA damage repair, nuclear membrane repair, chromosome fusion, DNA replication, angiogenesis and other ...
Yikai Lu, Mengmeng Zhao, Li Chen, Yan Wang, Tianhao Liu, Haipeng Liu   +5 more
openaire   +3 more sources

High cGAS-STING expression associates with improved efficacy of neoadjuvant chemo-immunotherapy in head and neck squamous cell carcinoma

Frontiers in Oncology
PurposeNeoadjuvant chemo-immunotherapy (NACI) has demonstrated significant clinical advantages in head and neck squamous cell carcinomas (HNSCC), while clinical responses vary in different patients.
Miao Wang, Menglin Shi, Yiming Ding, Zishanbai Zhang, Yuze Ge, Zhixin Li, Yixin Jing, Honglian Hu, Xiaohong Chen   +8 more
doaj   +1 more source

Chemical Thinning of Peach Fruits with CGA 15281 and CGA 178561

Journal of the American Society for Horticultural Science, 1978
Abstract Beta-chloroethyl-methyl-bis-benzyloxy-silane (CGA 15281) was applied to 6 Eastern U.S. grown peach ( Prunus persica (L.) Batsch) cultivars. Thinning response varied considerably with cultivar, timing, concentration and year.
openaire   +1 more source

The Gas Content in Galactic Disks: Correlation with Kinematics

, 2005
We consider the relationship between the total HI mass in late-type galaxies and the kinematic properties of their disks. The mass $M_HI$ for galaxies with a wide variety of properties, from dwarf dIrr galaxies with active star formation to giant low ...
A. A. Smirnova, A. Boselli, A. G. Morozov, A. H. Broeils, A. Shapley, A. V. Zasov, A. V. Zasov, A. V. Zasov, A. V. Zasov, A. V. Zasov, A. V. Zasov, A. V. Zasov, A. V. Zasov, B. A. Vorontsov-Velyaminov, B. A. Vorontsov-Velyaminov, B. G. Elmegreen, B. Lewis, C. Martin, D. A. Hunter, D. Bettoni, D. Bizyaev, D. Sprayberry, E. J. Shaya, F. Casoli, F. Combes, F. Combes, F. D. Barazza, G. J. Bendo, I. D. Karachentsev, I. D. Karachentsev, I. D. Karachentsev, I. Karachentsev, J. Hewitt, J. Iglesias-Paramo, L. Cairos, L. Cairos, L. Makarova, L. Zee van, M. A. W. Verheijen, M. C. Martin, M. Kregel, N. Devereux, N. Yasuda, R. A. Swaters, R. B. Tully, R. Becker, R. Grijs de, R. Larson, R. Patterson, S. Boissier, S. Boissier, S. McGaugh, S. Pustilnik, T. Bremnes, T. Kranz, T. Wong, T. X. Thuan, V. L. Polyachenko, W. J. G. Block de, W. Quirk, W.-T. Kim   +60 more
core   +3 more sources

Elucidating the expression and role of cGAS in pan-cancer using integrated bioinformatics and experimental approaches

BMC Cancer
cGAS plays an important role in regulating both tumor immune responses and DNA damage repair. Nevertheless, there was little research that comprehensively analyzed the correlation between cGAS and the tumor microenvironment, immune cell infiltration, and
Zhen Lian, Xue Liu, Xue Li
doaj   +1 more source