Results 101 to 110 of about 41,079 (213)
Agonists and Inhibitors of the cGAS-STING Pathway
MoleculesThe cyclic GMP-AMP synthase (cGAS)-stimulator of interferon genes (STING) pathway is pivotal in immunotherapy. Several agonists and inhibitors of the cGAS-STING pathway have been developed and evaluated for the treatment of various diseases. The agonists
Xiaoxuan Yu +4 more
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Engineering cGAS-agonistic oligonucleotides as therapeutics for cancer immunotherapy
Molecular Therapy: Nucleic AcidsActivating cyclic GMP-AMP synthase-stimulator of interferon genes (cGAS-STING) holds great potential for cancer immunotherapy by eliciting type-I interferon (IFN-I) responses. Yet, current approaches to cGAS-STING activation rely on STING agonists, which
Shurong Zhou +8 more
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EMBO reports, 2017 Recognition of foreign nucleic acids by the immune system is essential to host protection against many viral and bacterial infections. It relies on the capacity of innate immune sensors to selectively distinguish self‐ and non‐self‐nucleic acids, on the basis of a variety of parameters including base modifications, sequence composition, length or ...
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cGAS–STING, an important signaling pathway in diseases and their therapy
MedCommSince cyclic guanosine monophosphate‐adenosine monophosphate synthase (cGAS)–stimulator of interferon genes (STING) signaling pathway was discovered in 2013, great progress has been made to elucidate the origin, function, and regulating mechanism of cGAS–
Qijie Li +5 more
doaj +1 more source
Nucleic acid sensors and programmed cell death [PDF]
, 2020 Liverpool, Layal +2 more
core +2 more sources