Results 101 to 110 of about 34,737 (190)
Fault Tolerant Scalable Support for Network Portability and Traffic Engineering [PDF]
, 2007 The P-SHIM6 architecture provides ISP independence to IPv6 sites without compromising scalability. This architecture is based on a middle-box, the P-SHIM6, which manages the SHIM6 protocol exchange on behalf of the nodes of a site, which are configured ...
Azcorra, Arturo +2 more
core +4 more sources
Protein & Cell, 2020 The cyclic GMP-AMP (cGAMP) synthase (cGAS) plays a critical role in host defense by sensing cytosolic DNA derived from microbial pathogens or mis-located cellular DNA. Upon DNA binding, cGAS utilizes GTP and ATP as substrates to synthesize cGAMP, leading
Mi Li, Hong-Bing Shu
doaj +1 more source
Securing route optimisation in NEMO [PDF]
, 2005 Third International Symposium on Modeling and Optimization in Mobile, Ad Hoc,and Wireless Networks. 4-6 April 2005. Riva del Garda, Trentino, ItalyThe network mobility (NEMO) basic support protocol enables mobile networks to change their point of ...
Bagnulo Braun, Marcelo Gabriel +3 more
core +3 more sources
The cGAS-STING pathway in atherosclerosis
Frontiers in Cardiovascular MedicineAtherosclerosis (AS), a chronic inflammatory disease, remains a leading contributor to cardiovascular morbidity and mortality. Recent studies highlight the critical role of the cGAS-STING pathway—a key innate immune signaling cascade—in driving AS progression.
Si-yu Wang +10 more
openaire +3 more sources
cGAS-STING signalings potentiate tumor progression via sustaining cancer stemness
Translational Oncology, 2022 The cytosolic DNA-sensing cGAS-STING pathway has been proved to be involved in tumor progression and influence the effect of cancer immunotherapy. However, little attentions have been paid to the role of cGAS-STING pathway on cancer stemness.
Fu-rao Liu +4 more
doaj
BMC Oral Health, 2021 Background DNA-sensing receptor cyclic GMP–AMP synthase (cGAS) and its downstream signaling effector stimulator of interferon genes (STING) present a novel role in anti-tumor immunity.
Chao Zhu +3 more
doaj +1 more source
Planetary Growth with Collisional Fragmentation and Gas Drag [PDF]
, 2010 As planetary embryos grow, gravitational stirring of planetesimals by embryos strongly enhances random velocities of planetesimals and makes collisions between planetesimals destructive.
Adachi +46 more
core +2 more sources
STING-mediated disruption of calcium homeostasis chronically activates ER stress and primes T cell death [PDF]
, 2019 STING gain-of-function mutations cause lung disease and T cell cytopenia through unknown mechanisms. Here, we found that these mutants induce chronic activation of ER stress and unfolded protein response (UPR), leading to T cell death by apoptosis in ...
Chen, Yu-Ju +6 more
core +1 more source
Paediatric obsessive-compulsive disorder and depressive symptoms: clinical correlates and CBT treatment outcomes. [PDF]
, 2014 Depression frequently co-occurs with paediatric obsessive-compulsive disorder (OCD), yet the clinical correlates and impact of depression on CBT outcomes remain unclear.
AM Garcia +49 more
core +1 more source
cGAS surveillance of micronuclei links genome instability to innate immunity
Nature, 2017 DNA is strictly compartmentalized within the nucleus to prevent autoimmunity; despite this, cyclic GMP–AMP synthase (cGAS), a cytosolic sensor of double-stranded DNA, is activated in autoinflammatory disorders and by DNA damage.
K. Mackenzie +16 more
semanticscholar +1 more source