USP8‐Governed MDA5 Homeostasis Promotes Innate Immunity and Autoimmunity
Advanced Science, EarlyView.This study reveals that USP8 stabilizes MDA5 via AKT‐mediated phosphorylation (Ser718), enhancing their interaction and MDA5 deubiquitination. USP8 inactivation degrades MDA5, suppressing type I IFN and cytokine production. Pharmacological inhibition of USP8/AKT alleviates MDA5‐driven autoimmunity, demonstrating the USP8‐MDA5 axis as a therapeutic ...
Qimin Zhang +9 more
wiley +1 more source
EVALUATION OF CGA 293343 FOR CONTROL OF SUGARBEET WIREWORMS IN WATERMELON, 1998 [PDF]
, 1999 C. F. Fouche +3 more
openalex +1 more source
Advanced Science, EarlyView.The bacterial Type VI secretion system (T6SS) emerges as a sophisticated virulence mechanism, leveraging the dual‐function effector TkeA from Yersinia pseudotuberculosis. TkeA concurrently damages rival bacteria and host cell DNA, triggering the host's cGAS‐STING‐TNF pathway and inducing apoptosis.
Li Song +13 more
wiley +1 more source
Development of a microplate assay for serum chromogranin A (CgA): Establishment of normal reference values and detection of elevated CgA in malignant diseases [PDF]
, 1999 Tsu‐Lan Wu +4 more
openalex +1 more source
Cryo‐Inactivated Cancer Cells Derived Magnetic Micromotors for Tumor Immunotherapy
Advanced Science, EarlyView.Cryo‐inactivated cancer cell‐based magnetic micromotors are developed for synergistic tumor immunotherapy via magnetic targeting. These micromotors can induce ferroptosis and immunogenic cell death, deliver tumor antigens, and activate the Mn2+‐dependent cGAS‐STING pathway. The system effectively suppresses tumor progression, recurrence, and metastasis,
Qingfei Zhang +3 more
wiley +1 more source
cGAS-STING targeting offers therapy choice in lung diseases
Biology DirectCyclic GMP/AMP (cGAMP) synthase (cGAS), along with the endoplasmic reticulum (ER)-associated stimulator of interferon genes (STING), are crucial elements of the type 1 interferon response.
Yu Wang +5 more
doaj +1 more source
Streptavidin Promotes DNA Binding and Activation of cGAS to Enhance Innate Immunity
iScience, 2020 Summary: cGAS/STING signaling plays an essential role in sensing cytosolic DNA. cGAS activity is regulated by posttranslational modifications and binding partners. cGAS interactome largely includes mammalian or viral proteins.
Yanqiong Zhang +13 more
doaj
EFFECT OF TIMING ON THE EFFICACY OF MERIDIAN (CGA 293,343: THIAMETHOXAM) FOR CONTROL OF WHITE GRUBS IN TURF, 1998 [PDF]
, 2000 David W. Held +5 more
openalex +1 more source
BMC CancercGAS plays an important role in regulating both tumor immune responses and DNA damage repair. Nevertheless, there was little research that comprehensively analyzed the correlation between cGAS and the tumor microenvironment, immune cell infiltration, and
Zhen Lian, Xue Liu, Xue Li
doaj +1 more source
EFFECT OF POST-TREATMENT IRRIGATION ON THE EFFICACY OF CGA 293,343 (MERIDIAN) AGAINST WHITE GRUBS IN TURF 1998. [PDF]
, 2000 David W. Held +6 more
openalex +1 more source