Results 81 to 90 of about 34,737 (190)

Structural mechanism of cGAS inhibition by the nucleosome

Nature, 2020
The DNA sensor cyclic GMP-AMP synthase (cGAS) initiates innate immune responses following microbial infection, cellular stress and cancer1. Upon activation by double-stranded DNA, cytosolic cGAS produces 2'3' cGMP-AMP, which triggers the induction of inflammatory cytokines and type I interferons 2-7.
Zuzanna Kozicka, Zuzanna Kozicka, Andrea Ablasser, Ruud Hovius, Selene Glück, Simone Cavadini, Simone Cavadini, Ganesh R. Pathare, Ganesh R. Pathare, Baptiste Guey, Kristina Makasheva, Nicolas H. Thomä, Nicolas H. Thomä, Beat Fierz, Joscha Weiss, Joscha Weiss, Pauline Melenec, Georg Kempf, Georg Kempf, Alexiane Decout   +19 more
openaire   +4 more sources

Cell-free protein synthesis with technical additives – expanding the parameter space of in vitro gene expression

Beilstein Journal of Organic Chemistry
Biocatalysis has established itself as a successful tool in organic synthesis. A particularly fast technique for screening enzymes is the in vitro expression or cell-free protein synthesis (CFPS).
Tabea Bartsch, Stephan Lütz, Katrin Rosenthal   +2 more
doaj   +1 more source

An API for IPv6 Multihoming based on HBA and CGA [PDF]

, 2005
EUNICE 2005. IFIP International Workshop on Networked Applications, Colmenarejo, Madrid/Spain, 6–8 July, 2005. (Proceedings of the 11th Open European Summer School EUNICE 2005: Networked Applications)This paper proposes an API for Multihoming in IPv6 ...
Bagnulo Braun, Marcelo Gabriel, García Martínez, Alberto, Martinez Yelmo, Isaias   +2 more
core   +2 more sources

Type I interferons in tuberculosis: Foe and occasionally friend [PDF]

, 2018
Tuberculosis remains one of the leading causes of mortality worldwide, and, despite its clinical significance, there are still significant gaps in our understanding of pathogenic and protective mechanisms triggered by Mycobacterium tuberculosis infection.
Mayer-Barber, K, Moreira-Teixeira, L, O'Garra, A, Sher, A   +3 more
core   +1 more source

Activating cGAS–STING axis contributes to neuroinflammation in CVST mouse model and induces inflammasome activation and microglia pyroptosis

Journal of Neuroinflammation, 2022
Background Neuroinflammation-induced injury is intimately associated with poor prognosis in patients with cerebral venous sinus thrombosis (CVST).
Rui Ding, Haiyan Li, Yaqi Liu, Weiyang Ou, Xifang Zhang, Huihui Chai, Xiaofei Huang, Weijie Yang, Qiujing Wang   +8 more
semanticscholar   +1 more source

The proto-oncogene SRC phosphorylates cGAS to inhibit an antitumor immune response

JCI Insight, 2023
Cyclic GMP-AMP synthase (cGAS) is a DNA sensor and responsible for inducing an antitumor immune response. Recent studies reveal that cGAS is frequently inhibited in cancer, and therapeutic targets to promote antitumor cGAS function remain elusive. SRC is
William Dunker, Shivam A. Zaver, Jose Mario Bello Pineda, Cameron J. Howard, Robert K. Bradley, Joshua J. Woodward   +5 more
doaj   +1 more source

Treatment decision-making capacity in children and adolescents hospitalized for an acute mental disorder: The role of cognitive functioning and psychiatric symptoms [PDF]

, 2017
OBJECTIVE: This study was conducted to assess treatment decision-making capacity (TDMC) in a child and adolescent psychiatric sample and to verify possible associations between TDMC, psychiatric symptom severity, and cognitive functioning.
Ferracuti, Stefano, Ferrara, Mauro, Lapponi, Elisa, Mandarelli, Gabriele, Pace, Giulia, Sabatello, Ugo   +5 more
core   +1 more source

cGAS-STING, an important pathway in cancer immunotherapy

Journal of Hematology & Oncology, 2020
Cytosolic DNA sensing, the cyclic GMP-AMP synthase-stimulator of interferon genes (cGAS-STING) pathway, is an important novel role in the immune system.
Minlin Jiang, Peixin Chen, Lei Wang, Wei Li, Bin Chen, Yu Liu, Hao Wang, Sha Zhao, Lingyun Ye, Yayi He, Caicun Zhou   +10 more
semanticscholar   +1 more source

cGAS is predominantly a nuclear protein [PDF]

, 2018
cGAS is an intracellular innate immune sensor that detects double-stranded DNA. The presence of billions of base pairs of genomic DNA in all nucleated cells raises the question of how cGAS is not constitutively activated. A widely accepted explanation for this is the sequestration of cGAS in the cytosol, which is thought to prevent cGAS from accessing ...
Volkman, Hannah E, Cambier, Stephanie, Gray, Elizabeth E, Stetson, Daniel B   +3 more
openaire   +2 more sources

CGAS: comparative genomic analysis server [PDF]

Bioinformatics, 2009
Abstract Summary: Comparative approach is one of the most essential methods for extracting functional and evolutionary information from genomic sequences. So far, a number of sequence comparison tools have been developed, and most are either for on-site use, requiring program installation but providing a wide variety of analyses, or for ...
Hidemi Watanabe, Masumi Itoh
openaire   +2 more sources