Results 81 to 90 of about 41,079 (213)

RSK2-mediated cGAS phosphorylation induces cGAS chromatin-incorporation-mediated cell transformation and cancer cell colony growth

Cell Death Discovery
Cyclic guanosine-adenosine monophosphate synthase (cGAS) is a key cytosolic DNA sensor that plays a pivotal role in the innate immune response. Although a decade of research on the cGAS has advanced our understanding of inflammasome formation, cytokine ...
Weidong Chen, Ga-Eun Lee, Dohyun Jeung, Jiin Byun, Juan Wu, Xianzhe Li, Joo Young Lee, Han Chang Kang, Hye Suk Lee, Kwang Dong Kim, Soo-Bin Nam, Cheol-Jung Lee, Young Jik Kwon, Yong-Yeon Cho   +13 more
doaj   +1 more source

Regulation and Function of the cGAS-STING Pathway: Mechanisms, Post-Translational Modifications, and Therapeutic Potential in Immunotherapy

Drug Design, Development and Therapy
Yuhan Chen,1,* Si Yue,1,* Lingyan Yu,1,* Jinghao Cao,1 Yingchao Liu,1 Aoli Deng,1 Yajuan Lu,1 Jing Yang,1 Huanjuan Li,1 Jing Du,1 Jun Xia,1 Yanchun Li,2 Yongming Xia3 1Laboratory Medicine Center, Department of Clinical Laboratory, Zhejiang ...
Chen Y, Yue S, Yu L, Cao J, Liu Y, Deng A, Lu Y, Yang J, Li H, Du J, Xia J, Li Y, Xia Y   +12 more
doaj  

When Companies Don’t Make the Ad: A Multi-Method Inquiry into the Differential Effectiveness of Consumer-Generated Advertising [PDF]

, 2013
This four-part multi-method investigation into the under-researched yet increasingly prevalent phenomenon of consumer-generated advertising (CGA) confirms a performance advantage over traditional advertising and suggests a rationale for this differential.
Brunel, Frédéric, Fournier, Susan, Lawrence, Benjamin   +2 more
core   +2 more sources

Focus on the cGAS-STING Signaling Pathway in Sepsis and Its Inflammatory Regulatory Effects

Journal of Inflammation Research
Yupeng Han,1,2,* Liangcheng Qiu,1,2,* Haixing Wu,1,2,* Zhiwei Song,3 Peng Ke,1,2 Xiaodan Wu1,2 1Department of Anesthesiology, Fujian Provincial Hospital, Shengli Clinical Medical College of Fujian Medical University, Fuzhou, Fujian, People’s ...
Han Y, Qiu L, Wu H, Song Z, Ke P, Wu X
doaj  

Bubble dissolution in horizontal turbulent bubbly flow in domestic central heating system [PDF]

, 2013
In a domestic central heating system, the phenomenon of microbubble nucleation and detachment on the surface of a boiler heat exchanger finds its origins in the high surface temperature of the wall and consequential localised super saturation ...
Brunel University, Fsadni, A.M., Ge, Y.T., University of London, Wang, H.S.   +4 more
core   +1 more source

Targeting the cGAS‐STING Pathway Inhibits Peripheral T‐cell Lymphoma Progression and Enhances the Chemotherapeutic Efficacy

Advanced Science
Peripheral T‐cell lymphoma (PTCL) is a highly heterogeneous group of mature T‐cell malignancies. The efficacy of current first‐line treatment is dismal, and novel agents are urgently needed to improve patient outcomes.
Xueying Lu, Shunan Wang, Xin Hua, Xiao Chen, Mengtao Zhan, Qiaoyun Hu, Lei Cao, Zijuan Wu, Wei Zhang, Xiaoling Zuo, Renfu Gui, Lei Fan, Jianyong Li, Wenyu Shi, Hui Jin   +14 more
doaj   +1 more source

Review of Excessive Cytosolic DNA and Its Role in AIM2 and cGAS-STING Mediated Psoriasis Development

Clinical, Cosmetic and Investigational Dermatology
Tongtong Xu,1,* Xiaojing Zhong,1,* Nana Luo,2,* Wenyi Ma,1 Pingsheng Hao2 1School of Clinical Medicine, Chengdu University of Traditional Chinese Medicine, Chengdu, People’s Republic of China; 2Department of Dermatology, Hospital of Chengdu ...
Xu T, Zhong X, Luo N, Ma W, Hao P
doaj  

HERC5-catalyzed ISGylation potentiates cGAS-mediated innate immunity

Cell Reports
Summary: The cytosolic DNA sensor cyclic GMP-AMP synthase (cGAS) is essential to elicit type I interferon cascade response; thus, the activity of cGAS must be strictly regulated to boost the antiviral innate immunity.
Lei Chu, Li Qian, Yu Chen, Shengnan Duan, Ming Ding, Wu Sun, Wei Meng, Juanjuan Zhu, Quanyi Wang, Haiping Hao, Chen Wang, Shufang Cui   +11 more
doaj   +1 more source

Eribulin induces micronuclei and enhances the nuclear localization of cGAS in triple-negative breast cancer cells

Scientific Reports
Eribulin (ERI), clinically utilized for locally advanced or metastatic breast tumors, has shown potential links to the immune system. Notably, the cGAS-STING pathway, a key component of innate immunity, has gained prominence. Yet, limited reports explore
Hideyuki Yamada, Mamoru Takada, Dhaval Ghone, Muhan Yu, Takeshi Nagashima, Hiroshi Fujimoto, Junta Sakakibara, Yoshie Hasegawa, Shintaro Takao, Akimitsu Yamada, Kazutaka Narui, Takashi Ishikawa, Aussie Suzuki, Masayuki Otsuka   +13 more
doaj   +1 more source

STING-mediated disruption of calcium homeostasis chronically activates ER stress and primes T cell death [PDF]

, 2019
STING gain-of-function mutations cause lung disease and T cell cytopenia through unknown mechanisms. Here, we found that these mutants induce chronic activation of ER stress and unfolded protein response (UPR), leading to T cell death by apoptosis in ...
Chen, Yu-Ju, Dobbs, Nicole, Liou, Jen, Miner, Jonathan J, Sakai, Tomomi, Wu, Jianjun, Yan, Nan   +6 more
core   +1 more source