Serum Alpha and
Annals of Neurology, 2023 The objective of this study was to analyze the evolution of alpha and beta‐CGRP circulating levels throughout CGRP monoclonal antibodies (mAbs) treatment in patients with chronic migraine (CM).
Gabriel Gárate +6 more
openalex +2 more sources
Evaluation of mRNA Expression of Calcitonin Gene-Dependent Peptide (CGRP) and Rat Calcitonin (rCT) in the Periaqueductal Gray Area (PAG) of Diabetic Rats in the Formalin Test [PDF]
Majallah-i Dānishgāh-i ’Ulūm-i Pizishkī-i Īlām, 2022 Introduction: CGRP and rCT are involved in descending pain control areas. This study aimed to evaluate the effect of intracerebroventricular administration (ICV) of CGRP and rCT on mRNA expression of CGRP and rCT peptides in the Periaqueductal Gray Area (
Olya Moshiri +4 more
doaj +2 more sources
A novel bioactive peptide-peptoid hybrid of alpha-calcitonin gene-related peptide protects against pressure-overload induced heart failure [PDF]
Frontiers in PharmacologyBackgroundAlpha-calcitonin gene-related peptide (α-CGRP) is a cardioprotective neuropeptide. However, due to low bioavailability, its use as a therapeutic agent is limited.
Ambrish Kumar +4 more
doaj +2 more sources
Tear fluid CGRP rises during glyceryl trinitrate-induced headache in migraine patients [PDF]
The Journal of Headache and PainBackground Calcitonin gene-related peptide (CGRP) plays an important role in migraine pathophysiology and is a marker of trigeminal activity. We investigated tear fluid CGRP levels interictally and ictally using the glyceryl trinitrate (GTN) experimental
Katharina Kamm +3 more
doaj +2 more sources
The Journal of Headache and Pain, 2019 Background Monoclonal antibodies (mAbs) towards CGRP or the CGRP receptor show good prophylactic antimigraine efficacy. However, their site of action is still elusive.
Jacob C. A. Edvinsson +6 more
doaj +2 more sources
Trigeminal nerve root compression induced neuroinflammatory response promotes mechanical allodynia through the CGRP/SP-Piezo2 axis via Ca<sup>2+</sup> signaling. [PDF]
Cell Mol Biol LettLiao X +9 more
europepmc +2 more sources
CGRP physiology, pharmacology, and therapeutic targets: Migraine and beyond.
Physiological Reviews, 2022 Calcitonin gene-related peptide (CGRP) is a neuropeptide with diverse physiological functions. Its two isoforms (α and β) are widely expressed throughout the body in sensory neurons, as well as in other cell types, such as motor neurons and ...
A. Russo, D. Hay
semanticscholar +1 more source
Shared and independent roles of CGRP and PACAP in migraine pathophysiology
The Journal of Headache and Pain, 2023 The neuropeptides calcitonin gene-related peptide (CGRP) and pituitary adenylate cyclase-activating polypeptide (PACAP) have emerged as mediators of migraine pathogenesis.
Adisa Kuburas, A. Russo
semanticscholar +1 more source
A Scoping Review and Meta-Analysis of Anti-CGRP Monoclonal Antibodies: Predicting Response
Pharmaceuticals, 2023 Calcitonin gene-related peptide-targeted monoclonal antibodies (CGRP mAbs) are increasingly being used as preventive treatments for migraine. Their effectiveness and safety were established through numerous randomized placebo-controlled trials and real ...
Jaehwa Hong +5 more
semanticscholar +1 more source
Schwann cell endosome CGRP signals elicit periorbital mechanical allodynia in mice
Nature Communications, 2022 Efficacy of monoclonal antibodies against calcitonin gene-related peptide (CGRP) or its receptor (calcitonin receptor-like receptor/receptor activity modifying protein-1, CLR/RAMP1) implicates peripherally-released CGRP in migraine pain.
Francesco De Logu +18 more
semanticscholar +1 more source