Results 1 to 10 of about 50,213 (312)
Journal of Neurology, 2016 Migraine has been estimated to be the seventh highest cause of disability worldwide, and the third most common disease worldwide after dental caries and tension type headache. However, the use of currently available acute and prophylactic medications to control this condition, such as 5-HT1 agonists (triptans) and beta-blockers, is limited by side ...
Cauchi, M., Robertson, Neil
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The Journal of Headache and Pain, 2009 Dear Editor,Concentrations of substances in plasma, in this case CGRP,can be presented in several different to ways, such as pmol/l[1–7], pg/ml [8, 9] and just recently as ng/ml [10]. Thesedifferent concentrations can be compared when one usesthe molecular weight of 3,790 for CGRP but it takes 5–10 min of arithmetic to do that.
Tfelt-Hansen, Peer, Ashina, Messoud
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Anti-CGRP antibodies block CGRP-induced diarrhea in mice [PDF]
Neuropeptides, 2017 The multifunctional neuropeptide calcitonin gene-related peptide (CGRP) and its receptor are expressed throughout the gastrointestinal tract. Previous studies have shown that CGRP has roles in intestinal motility, water secretion, and inflammation. Furthermore, animal studies have demonstrated CGRP involvement in diarrhea secondary to C.
Eric A, Kaiser +6 more
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Calcitonin receptor-like receptor is expressed on gastrointestinal immune cells [PDF]
, 2002 Background/Aims: Pharmacological and morphological studies suggest that the gut mucosal immune system and local neuropeptide-containing neurones interact.
Göke, B. +5 more
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Glucose-Dependent Insulinotropic Polypeptide (GIP) Induces Calcitonin Gene-Related Peptide (CGRP)-I and Procalcitonin (Pro-CT) Production in Human Adipocytes [PDF]
, 2011 Context: Increased plasma levels of glucose-dependent insulinotropic polypeptide (GIP), calcitonin CT gene-related peptide (CGRP)-I, and procalcitonin (Pro-CT) are associated with obesity.
Christ-Crain, Mirjam +10 more
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The role of ECL2 in CGRP receptor activation: a combined modelling and experimental approach [PDF]
, 2013 The calcitonin gene-related peptide (CGRP) receptor is a complex of a calcitonin receptor-like receptor (CLR), which is a family B G-protein-coupled receptor (GPCR) and receptor activity modifying protein 1.
Alex C. Conner +13 more
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Triptans and CGRP blockade - impact on the cranial vasculature [PDF]
, 2017 The trigeminovascular system plays a key role in the pathophysiology of migraine. The activation of the trigeminovascular system causes release of various neurotransmitters and neuropeptides, including serotonin and calcitonin gene-related peptide ...
Alejandro Labastida-Ramírez +9 more
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New players in the preventive treatment of migraine. [PDF]
, 2015 Migraine is a common, chronic disorder of the brain causing much disability, as well as personal, familial and societal impact. Several oral preventive agents are available in different countries for the prevention of migraine, but none have performed ...
Mitsikostas, Dimos D, Rapoport, Alan M
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Lipidated Calcitonin Gene-Related Peptide (CGRP) Peptide Antagonists Retain CGRP Receptor Activity and Attenuate CGRP Action In Vivo [PDF]
Frontiers in Pharmacology, 2022 Signaling through calcitonin gene-related peptide (CGRP) receptors is associated with pain, migraine, and energy expenditure. Small molecule and monoclonal antibody CGRP receptor antagonists that block endogenous CGRP action are in clinical use as anti-migraine therapies.
Aqfan Jamaluddin +13 more
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Deletion of Tsc2 in nociceptors reduces target innervation, ion channel expression, and sensitivity to heat [PDF]
, 2018 The mechanistic target of rapamycin complex 1 (mTORC1) is known to regulate cellular growth pathways, and its genetic activation is sufficient to enhance regenerative axon growth following injury to the central or peripheral nervous systems.
Carlin, Dan +6 more
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