Results 91 to 100 of about 48,956 (312)

Impact of Galcanezumab on Total Pain Burden: A Post Hoc Analysis of a Phase 3, Randomized, Double-Blind, Placebo-Controlled Study in Patients with Episodic Cluster Headache

Journal of Pain Research, 2021
J Scott Andrews,1 David Kudrow,2 Mallikarjuna Rettiganti,1 Tina Oakes,1 Jennifer N Bardos,1 Richard Wenzel,1 Dulanji K Kuruppu,1 Charly Gaul,3 James M Martinez1 1Eli Lilly and Company, Indianapolis, IN, USA; 2California Medical Clinic for Headache, Santa
Andrews JS, Kudrow D, Rettiganti M, Oakes T, Bardos JN, Wenzel R, Kuruppu DK, Gaul C, Martinez JM   +8 more
doaj  

Biomaterial‐Based Emergency Intervention for Secondary Spinal Cord Injury

Small Science, EarlyView.
Emergency intervention using advanced biomaterials targets key pathological mechanisms to block secondary spinal cord injury (SCI) by inhibiting inflammation, reducing excitotoxicity, restoring the blood−spinal cord barrier, and limiting scar formation, which provides significant neural protection and promotes neural regeneration, offering promising ...
Jincheng Li, Qingzheng Zhang, Zongtai Liu, Weiguo Xu, Changfeng Fu, Jianxun Ding   +5 more
wiley   +1 more source

Evaluation of mRNA Expression of Calcitonin Gene-Dependent Peptide (CGRP) and Rat Calcitonin (rCT) in the Periaqueductal Gray Area (PAG) of Diabetic Rats in the Formalin Test

Majallah-i Dānishgāh-i ’Ulūm-i Pizishkī-i Īlām, 2022
Introduction: CGRP and rCT are involved in descending pain control areas. This study aimed to evaluate the effect of intracerebroventricular administration (ICV) of CGRP and rCT on mRNA expression of CGRP and rCT peptides in the Periaqueductal Gray Area (
Olya Moshiri, Javad Sajedianfard, Saeid Hosseinzadeh, Kaveh Rahimi, Saeedeh Ahmadi Jokani   +4 more
doaj  

C-fibers may modulate adjacent Aδ-fibers through axon-axon CGRP signaling at nodes of Ranvier in the trigeminal system

The Journal of Headache and Pain, 2019
Background Monoclonal antibodies (mAbs) towards CGRP or the CGRP receptor show good prophylactic antimigraine efficacy. However, their site of action is still elusive.
Jacob C. A. Edvinsson, Karin Warfvinge, Diana N. Krause, Frank W. Blixt, Majid Sheykhzade, Lars Edvinsson, Kristian A. Haanes   +6 more
doaj   +1 more source

Galcanezumab in episodic migraine: subgroup analyses of efficacy by high versus low frequency of migraine headaches in phase 3 studies (EVOLVE-1 & EVOLVE-2). [PDF]

, 2019
BACKGROUND: Patients with high-frequency episodic migraine (HFEM) have a greater disease burden than those with low-frequency episodic migraine (LFEM).
Day, Katie A., Lipsius, Sarah, Silberstein, Stephen D., Stauffer, Virginia L., Wilson, Maria-Carmen   +4 more
core   +1 more source

Induction of chronic migraine phenotypes in a rat model after environmental irritant exposure [PDF]

, 2017
Air pollution is linked to increased emergency department visits for headache and migraine patients frequently cite chemicals or odors as headache triggers, but the association between air pollutants and headache is not well understood.
Hurley, Joyce Harts, Johnson, Philip Lee, Kunkler, Phillip Edward, Oxford, Gerry Stephen, Zhang, LuJuan   +4 more
core   +1 more source

Perineural Invasion in Pancreatic Ductal Adenocarcinoma: Recapitulating Its Importance and Defining Future Directions

United European Gastroenterology Journal, EarlyView.
ABSTRACT Pancreatic ductal adenocarcinoma (PDAC) remains one of the most lethal malignancies, mainly due to its aggressive nature, early metastasis, diagnosis at late stages, and limited response to systemic anticancer therapy. Perineural invasion (PNI), defined as the infiltration of neoplastic cells along nerve fibers and within nerve sheaths, is ...
Martin Lovecek, Esra Dirimtekin, Ingrid Garajová, Giulia Gasparini, Stefano Crippa, Elisa Giovannetti, Dana Sochorova, Carmen Mota Reyes, Ihsan Ekin Demir, Pinar Uysal‐Onganer, on behalf TRANSPAN PNI Group   +10 more
wiley   +1 more source

A Novel Rat Model to Study Postsurgical Pain After Joint Replacement Surgery

Journal of Pain Research, 2022
Naoki Aoyama, Masashi Izumi, Toru Morimoto, Hiroyuki Wada, Junpei Dan, Yusuke Kasai, Yoshinori Satake, Koji Aso, Masahiko Ikeuchi Department of Orthopedic Surgery, Kochi Medical School, Kochi University, Nankoku, JapanCorrespondence: Masashi Izumi ...
Aoyama N, Izumi M, Morimoto T, Wada H, Dan J, Kasai Y, Satake Y, Aso K, Ikeuchi M   +8 more
doaj  

Neuropharmacological targets for drug action in vestibular sensory pathways [PDF]

, 2017
The use of pharmacological agents is often the preferred approach to the management of vestibular dysfunction. In the vestibular sensory pathways, the sensory neuroepithelia are thought to be influenced by a diverse number of neuroactive substances that ...
Jones, Timothy A, Lee, Choongheon
core   +3 more sources

The Impact of Environmental Pollution and Climate Change on Allergic Rhinitis and Lung Diseases

World Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.
ABSTRACT Environmental pollution and climate change seriously affect human health, leading to the onset and exacerbation of chronic respiratory diseases, such as allergic rhinitis and lung diseases. Over the past several decades, increasing air pollution and environmental exposure owing to global urbanization, industrialization, and rapid economic ...
Xin‐Yan Liu, Rui‐Ming Han, Yong‐Tai Wang, Dong‐Dong Zhu, Cui‐Da Meng   +4 more
wiley   +1 more source