Results 11 to 20 of about 48,956 (312)
Journal of Neurology, 2016 Migraine has been estimated to be the seventh highest cause of disability worldwide, and the third most common disease worldwide after dental caries and tension type headache. However, the use of currently available acute and prophylactic medications to control this condition, such as 5-HT1 agonists (triptans) and beta-blockers, is limited by side ...
M. Cauchi, Neil Robertson
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The Journal of Headache and Pain, 2009 Dear Editor,Concentrations of substances in plasma, in this case CGRP,can be presented in several different to ways, such as pmol/l[1–7], pg/ml [8, 9] and just recently as ng/ml [10]. Thesedifferent concentrations can be compared when one usesthe molecular weight of 3,790 for CGRP but it takes 5–10 min of arithmetic to do that.
Tfelt-Hansen, Peer, Ashina, Messoud
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Serotonin and CGRP in Migraine [PDF]
Annals of Neurosciences, 2012 Migraine is defined as recurrent attack of headache that are commonly unilateral and accompanied by gastrointestinal and visual disorders. Migraine is more prevalent in females than males with a ratio of 3:1. It is primarily a complex neurovascular disorder involving local vasodilation of intracranial, extracerebral blood vessels and simultaneous ...
Sanjeev Puri, Veena Puri, Milan Aggarwal
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The Scientific World JOURNAL, 2001 The presentation will focus on BIBN 4096 BS, since this compound is still the only potent calcitonin gene-related peptide (CGRP)-antagonist described so far[1].
M. Schindler, Henri Doods
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Frontiers in Pharmacology, 2020 It is known that calcitonin gene-related peptide (CGRP) plays a key role in pain modulation in the brain. There are high expressions of CGRP and CGRP receptor in anterior cingulate cortex (ACC), an important brain structure in pain modulation.
Ke-Sai Hou +5 more
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Nociceptive neuropeptide increases and periorbital allodynia in a model of traumatic brain injury. [PDF]
, 2012 OBJECTIVE: This study tests the hypothesis that injury to the somatosensory cortex is associated with periorbital allodynia and increases in nociceptive neuropeptides in the brainstem in a mouse model of controlled cortical impact (CCI) injury.
Amenta, Peter S. +4 more
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Calcitonin gene-related peptide is a potential autoantigen for CD4 T cells in type 1 diabetes
Frontiers in Immunology, 2022 The calcitonin gene-related peptide (CGRP) is a 37-amino acid neuropeptide with critical roles in the development of peripheral sensitization and pain. One of the CGRP family peptides, islet amyloid polypeptide (IAPP), is an important autoantigen in type
Wei Li +9 more
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Anti-CGRP antibodies block CGRP-induced diarrhea in mice [PDF]
Neuropeptides, 2017 The multifunctional neuropeptide calcitonin gene-related peptide (CGRP) and its receptor are expressed throughout the gastrointestinal tract. Previous studies have shown that CGRP has roles in intestinal motility, water secretion, and inflammation. Furthermore, animal studies have demonstrated CGRP involvement in diarrhea secondary to C.
Brandon J. Rea +7 more
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Nociceptor Neurons are Involved in the Host Response to Escherichia coli Urinary Tract Infections
Journal of Inflammation Research, 2022 Zhengdong Gao,1,2,* Yaxiao Liu,1,2,* Lekai Zhang,1,2 Zizhuo Yang,1,2 Linchen Lv,1,2 Shuai Wang,1,2 Lipeng Chen,1,2 Nan Zhou,1,2 Yaofeng Zhu,1 Xuewen Jiang,1 Benkang Shi,1,2 Yan Li1,2 1Department of Urology, Qilu Hospital of Shandong University ...
Gao Z +11 more
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The Journal of Headache and Pain, 2022 Background The clinical use of calcitonin gene-related peptide receptor (CGRP-R) antagonists and monoclonal antibodies against CGRP and CGRP-R has offered new treatment possibilities for migraine patients.
Sanne Hage La Cour +6 more
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