Evaluation of mRNA Expression of Calcitonin Gene-Dependent Peptide (CGRP) and Rat Calcitonin (rCT) in the Periaqueductal Gray Area (PAG) of Diabetic Rats in the Formalin Test [PDF]
Majallah-i Dānishgāh-i ’Ulūm-i Pizishkī-i Īlām, 2022 Introduction: CGRP and rCT are involved in descending pain control areas. This study aimed to evaluate the effect of intracerebroventricular administration (ICV) of CGRP and rCT on mRNA expression of CGRP and rCT peptides in the Periaqueductal Gray Area (
Olya Moshiri +4 more
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Клинический разбор в общей медицине, 2023 Background. Menstrual related migraine (MRM) occurs in 60% of women with migraine. These attacks are characterized by high intensity and poor response to abortive and prophylactic treatment.
Anna V. Berdnikova +4 more
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Advances in CGRP monoclonal antibodies as migraine therapy: A narrative review
Saudi Journal of Medicine and Medical Sciences, 2023 Migraine is a potentially disabling disorder, yet it remains underdiagnosed and undertreated. The release of the neuropeptide calcitonin gene-related peptide (CGRP) in the trigemino-cerebrovascular system plays a vital role in the evolution of migraine ...
Suruchi Aditya, Aditya Rattan
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Serum calcitonin gene related peptide (CGRP) levels in migraine: A study on its clinical correlation and diagnostic efficacy [PDF]
Romanian Journal of Neurology, 2021 Migraine is a primary headache disorder marked by recurrent unilateral headache episodes. Calcitonin gene related peptide (CGRP) plays major role in migraine pathophysiology.
Sofia Khatoon +7 more
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The Management of High-Frequency Episodic and Chronic Migraines with Calcitonin Gene-Related Peptide Monoclonal Antibody [PDF]
Анналы клинической и экспериментальной неврологии, 2023 Introduction. High prevalence of migraine and its impact on quality of life requires the development of original agents. In 2020, fremanezumab, a new calcitonin gene-related peptide monoclonal antibody was authorized in Russia.
Larisa A. Dobrynina +4 more
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Parabrachial calcitonin gene-related peptide neurons sex-specifically modulate behavior in anxiety assays during alcohol withdrawal. [PDF]
Front PharmacolParabrachial nucleus (PBN) neurons expressing Calcitonin Gene-Related Peptide (CGRP) modulate fear- and anxiety-like behavior. It is unknown if PBN(CGRP) neurons play a role in anxiety during withdrawal from alcohol or after repeated stress.
Van Doorn CE, Tyree JB, Jaramillo AA.
europepmc +2 more sources
Recent advances in targeting calcitonin gene-related peptide for the treatment of menstrual migraine
Medicine, 2022 . Menstrual migraine (MM) has a longer duration and higher drug resistance than non-perimenstrual migraine. Calcitonin gene-related peptide (CGRP) and CGRP receptors are expressed in the peripheral and central nervous systems throughout the ...
Yan Jiang, MMed, Zhen-Lun Huang, BMed
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Calcitonin gene-related peptide is a potential autoantigen for CD4 T cells in type 1 diabetes
Frontiers in Immunology, 2022 The calcitonin gene-related peptide (CGRP) is a 37-amino acid neuropeptide with critical roles in the development of peripheral sensitization and pain. One of the CGRP family peptides, islet amyloid polypeptide (IAPP), is an important autoantigen in type
Wei Li +9 more
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Frontiers in Pharmacology, 2020 It is known that calcitonin gene-related peptide (CGRP) plays a key role in pain modulation in the brain. There are high expressions of CGRP and CGRP receptor in anterior cingulate cortex (ACC), an important brain structure in pain modulation.
Ke-Sai Hou +5 more
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Patient Preference and Adherence, 2022 Oralee J Varnado,1 Janna Manjelievskaia,2 Wenyu Ye,1 Allison Perry,2 Kory Schuh,1 Richard Wenzel1 1Value, Evidence, and Outcomes, Eli Lilly and Company, Indianapolis, IN, USA; 2Watson Health Life Sciences, Research & Analytics, IBM Watson Health ...
Varnado OJ +5 more
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