Results 31 to 40 of about 10,225 (206)

Synthesis and Pharmacological Evaluation of Some Phenylpyrazolo Indoquinoxaline Derivatives

E-Journal of Chemistry, 2011
Indoloquinoxalin was fused with 2,3 diphenyl quinoxaline by a methylene bridge which was then allowed for acetylation. The acetylated product was made to react with different aromatic aldehydes to give chalcones.
CH. Sridevi, K. Balaji, A. Naidu
doaj   +1 more source

Molecular docking and dynamics analysis of halogenated imidazole chalcone as anticancer compounds [PDF]

Pharmacia, 2023
Cancer is one of the three biggest causes of death in the world. The development of new drugs against this disease is a serious study that must be carried out in order to reduce mortality and extend the life span of sufferers.
Winarto Haryadi, Harno Dwi Pranowo
doaj   +3 more sources

Design, Synthesis, and Evaluation of Bis-Chalcones and Bis-Flavones as Selective COX-2 Inhibitors. [PDF]

Chem Biol Drug Des
Novel bis‐chalcones were successfully synthesized and demonstrated COX‐2 selective inhibition and the ability to inhibit PGE2 production in whole human blood. Notably, a monomeric chalcone with a similar substitution pattern exhibited even greater activity, providing valuable insights to guide the future design and optimization of flavonoid‐based COX‐2
Pereira R, Freitas M, Araújo AN, Silva VLM, Fernandes E.   +4 more
europepmc   +2 more sources

Synthesis of Some Novel Chalcone and 3,5‐Disubstituted Pyrazoline Derivatives: Evaluation of Their α‐Amylase and α‐Glucosidase Inhibitory Activities In Vitro and In Silico [PDF]

Arch Pharm (Weinheim)
A novel pyrazoline derivative (P2) was synthesized and demonstrated potent α‐glucosidase inhibition (IC50 = 2.10 µM), significantly surpassing acarbose and highlighting its promise as an effective oral antidiabetic agent. ABSTRACT This study reports the synthesis of some novel chalcone (C1–C3) and 3,5‐disubstituted pyrazoline derivatives (P1–P3 ...
Erbay F, Akatin M, Demir F, Kahriman N, Colak A, Ertunga N, Küçük M.   +6 more
europepmc   +2 more sources

Antiproliferative activity and p53 upregulation effects of chalcones on human breast cancer cells

Journal of Enzyme Inhibition and Medicinal Chemistry, 2019
Chalcones are valuable structures for drug discovery due to their broad bioactivity spectrum. In this study, we evaluated 20 synthetic chalcones against estrogen-receptor-positive breast cancer cells (MCF-7 line) and triple-negative breast cancer (TNBC ...
Mariana Bastos dos Santos, Daiane Bertholin Anselmo, Jéssica Gisleine de Oliveira, Bruna V. Jardim-Perassi, Diego Alves Monteiro, Gabriel Silva, Eleni Gomes, Ana Lucia Fachin, Mozart Marins, Débora Aparecida Pires de Campos Zuccari, Luis Octavio Regasini   +10 more
doaj   +1 more source

Mechanochemical synthesis of indolyl chalcones with antiproliferative activity

Green Chemistry Letters and Reviews, 2022
An efficient eco-friendly one-step mechanochemical synthesis of indole hybrid chalcones via the Claisen–Schmidt condensation of 1-methylindole-3-carboxaldehyde with various substituted acetophenones is described using liquid assisted grinding in a high ...
Zuzana Kudličková, Martin Stahorský, Radka Michalková, Mária Vilková, Matej Baláž   +4 more
doaj   +1 more source

Thermal study of chalcones [PDF]

Journal of Thermal Analysis and Calorimetry, 2018
Chalcones α-β-unsaturated ketones are found in large plant species. Synthesis of chalcones and its three analogues hydroxy group at 2′, 3′ and 4′ positions (2–4) was carried out. The studies of thermal behavior were made by thermogravimetry (TG) and differential scanning calorimetry, both under oxygen and nitrogen purge gases.
Marcelo Kobelnik, Leonardo Miziara Barboza Ferreira, Luis Octavio Regasini, Luiz Antonio Dutra, Vanderlan da Silva Bolzani, Clóvis Augusto Ribeiro   +5 more
openaire   +2 more sources

The Maize ZmbHLH118 Transcription Factor Regulates Vacuolar Nitrate Loading by the NO3− Transporter ZmCLCa

Advanced Science, EarlyView.
In maize, the bHLH transcription factor ZmbHLH118 directly binds to the promoter of ZmCLCa and inhibits its expression. Tonoplast‐localized ZmCLCa mediates NO3− influx into the vacuole to regulate intracellular NO3− homeostasis, modulating nitrate uptake and metabolism, plant growth, and grain yield.
Chaonan Zhang, Elsa Demes‐Causse, Xujian Li, Zhenhui Guo, Hanshu Zhao, Huairong Cao, Yajing Song, Lijun Mu, Kaikai Zhang, Jing Zhang, Zhongtao Jia, Lixing Yuan, Alexis De Angeli, Jingbo Zhang   +13 more
wiley   +1 more source

Antitrypanosomal and Antileishmanial Activity of Chalcones and Flavanones from Polygonum salicifolium

Pathogens, 2021
Trypanosomiasis and leishmaniasis are a group of neglected parasitic diseases caused by several species of parasites belonging to the family Trypansomatida. The present study investigated the antitrypanosomal and antileishmanial activity of chalcones and
Ahmed M. Zheoat, Samya Alenezi, Ehab Kotb Elmahallawy, Marzuq A. Ungogo, Ali H. Alghamdi, David G. Watson, John O. Igoli, Alexander I. Gray, Harry P. de Koning, Valerie A. Ferro   +9 more
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chalcones [PDF]

, 2014
Citation: 'chalcones' in the IUPAC Compendium of Chemical Terminology, 3rd ed.; International Union of Pure and Applied Chemistry; 2006. Online version 3.0.1, 2019. 10.1351/goldbook.C00966 • License: The IUPAC Gold Book is licensed under Creative Commons Attribution-ShareAlike CC BY-SA 4.0 International for individual terms.
openaire   +1 more source