A chalcone derivative reactivates latent HIV-1 transcription through activating P-TEFb and promoting Tat-SEC interaction on viral promoter. [PDF]
, 2017 The principal barrier to the eradication of HIV/AIDS is the existence of latent viral reservoirs. One strategy to overcome this barrier is to use latency-reversing agents (LRAs) to reactivate the latent proviruses, which can then be eliminated by ...
Ao, Ming-Tao +9 more
core +2 more sources
Synthesis, spectral correlation and insect antifeedant activities of some 2-benzimidazole chalcones
Journal of Saudi Chemical Society, 2016 Some substituted styryl 2-benzimidazole ketones have been synthesised by fly-ash:H2SO4 catalysed aldol condensation of 2-benzimidazole methyl ketone and various substituted benzaldehydes in microwave oven. The yields of these chalcones are more than 70%.
P. Janaki, K.G. Sekar, G. Thirunarayanan
doaj +1 more source
Frontiers in Pharmacology, 2021 Chalcones are among the leading bioactive flavonoids with a therapeutic potential implicated to an array of bioactivities investigated by a series of preclinical and clinical studies.
Bahare Salehi +22 more
doaj +1 more source
Phthalocyanine-chalcone conjugates
Journal of Porphyrins and Phthalocyanines, 2016 A phthalocyanine-chalcone conjugate was previously reported to retain the full photodynamic activity of the phthalocyanine and a slightly lowered antivascular effect of the chalcone. Assuming that it was due to an insufficient release of the chalcone, we described here several grafting modes applied to the preparation of phthalocyanine-chalcone ...
Aribi, Fallia +15 more
openaire +3 more sources
Chalcones as versatile synthons for the synthesis of 5- and 6-membered nitrogen heterocylces [PDF]
, 2014 Chalcones belong to the flavonoid family which constitutes one of the major classes of naturally occurring oxygen heterocyclic compounds. The alpha,beta-unsaturated carbonyl system of chalcones possesses two electrophilic reactive centers allowing them ...
Albuquerque, Hélio +3 more
core +1 more source
Chalcones to control Alternaria alternata in murcott tangor fruits
Bioscience Journal, 2016 Alternaria brown spot (ABS), caused by the fungus Alternaria alternata pathotype tangerine, is one of the main phytosanitary problems for mandarin growers.
Renato Barbosa Camargos +8 more
doaj +3 more sources
BIOLOGICAL ACTIVITIES AND NOVEL APPLICATIONS OF CHALCONES [PDF]
Planta Daninha, 2016 This review provides information on the biological activities of chalcones (whether natural or synthetic derivatives) on different organisms, as well as an overview of the functions and possible new applications of these plant secondary metabolites on ...
C. DÍAZ-TIELAS +3 more
doaj +2 more sources
Design, synthesis, docking studies and monoamine oxidase inhibition of a small library of 1-acetyl- and 1-thiocarbamoyl-3,5-diphenyl-4,5-dihydro-(1h)-pyrazoles [PDF]
, 2019 New N-acetyl/N-thiocarbamoylpyrazoline derivatives were designed and synthesized in high yields to assess their inhibitory activity and selectivity against human monoamine oxidase A and B.
Carradori, Simone +8 more
core +2 more sources
A Comprehensive Review of Aminochalcones
Molecules, 2020 Chalcones, members of the flavonoid family, display a plethora of interesting biological activities including but not limited to antioxidant, anticancer, antimicrobial, anti-inflammatory, and antiprotozoal activities.
Rimsha Irfan +3 more
doaj +1 more source
Molecular docking and dynamics analysis of halogenated imidazole chalcone as anticancer compounds [PDF]
Pharmacia, 2023 Cancer is one of the three biggest causes of death in the world. The development of new drugs against this disease is a serious study that must be carried out in order to reduce mortality and extend the life span of sufferers.
Winarto Haryadi, Harno Dwi Pranowo
doaj +3 more sources