Results 21 to 30 of about 226,086 (342)
Molecules, 2020 For large-scale bioproduction, thermal stability is a crucial property for most industrial enzymes. A new method to improve both the thermal stability and activity of enzymes is of great significance.
Chunmeng Xu +5 more
doaj +1 more source
Frontiers in Cell and Developmental Biology, 2021 For fully differentiated, long lived cells the maintenance of protein homeostasis (proteostasis) becomes a crucial determinant of cellular function and viability.
Shenae L. Cafe +7 more
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UPR proteins IRE1 and PERK switch BiP from chaperone to ER stress sensor
Nature Structural & Molecular Biology, 2019 BiP is a major endoplasmic reticulum (ER) chaperone and is suggested to act as primary sensor in the activation of the unfolded protein response (UPR). How BiP operates as a molecular chaperone and as an ER stress sensor is unknown.
M. Kopp +4 more
semanticscholar +1 more source
Calreticulin: Roles in Cell-Surface Protein Expression
Membranes, 2014 In order to perform their designated functions, proteins require precise subcellular localizations. For cell-surface proteins, such as receptors and channels, they are able to transduce signals only when properly targeted to the cell membrane ...
Yue Jiang +2 more
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HtrA chaperone activity contributes to host cell binding in
Gut Pathogens, 2011 Background Acute gastroenteritis caused by the food-borne pathogen Campylobacter jejuni is associated with attachment of bacteria to the intestinal epithelium and subsequent invasion of epithelial cells. In C.
Bæk Kristoffer T +2 more
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, 2010 The maintenance of the levels and correct folding state of proteins (proteostasis) is a fundamental prerequisite for life. Life has evolved complex mechanisms to maintain proteostasis and many of these that operate inside cells are now well understood.
Dabbs, Rebecca A +4 more
openaire +5 more sources
The chaperone effect in scientific publishing [PDF]
Proceedings of the National Academy of Sciences of the United States of America, 2018 Experience plays a critical role in crafting high-impact scientific work. This is particularly evident in top multidisciplinary journals, where a scientist is unlikely to appear as senior author if he or she has not previously published within the same ...
V. Sekara +5 more
semanticscholar +1 more source
eLife, 2019 Loss of proteostasis and cellular senescence are key hallmarks of aging, but direct cause-effect relationships are not well understood. We show that most yeast cells arrest in G1 before death with low nuclear levels of Cln3, a key G1 cyclin extremely ...
David F Moreno +5 more
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Frontiers in Pharmacology, 2023 Introduction: We previously identified that Cathepsin V (CTSV) expression is associated with poor prognosis in ER+ breast cancer, particularly within the Luminal A subtype.
Naphannop Sereesongsaeng +4 more
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Cells, 2021 Background: Upregulation of Heath Shock Protein 70 (HSP70) chaperones supports cancer cell survival. Their high homology causes a challenge to differentiate them in experimental or prevention and treatment strategies.
Rajani Rai +4 more
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