Results 31 to 40 of about 285,190 (188)

Novel Chaperones RrGroEL and RrGroES for Activity and Stability Enhancement of Nitrilase in Escherichia coli and Rhodococcus ruber

Molecules, 2020
For large-scale bioproduction, thermal stability is a crucial property for most industrial enzymes. A new method to improve both the thermal stability and activity of enzymes is of great significance.
Chunmeng Xu, Lingjun Tang, Youxiang Liang, Song Jiao, Huimin Yu, Hui Luo   +5 more
doaj   +1 more source

Proteostasis in the Male and Female Germline: A New Outlook on the Maintenance of Reproductive Health

Frontiers in Cell and Developmental Biology, 2021
For fully differentiated, long lived cells the maintenance of protein homeostasis (proteostasis) becomes a crucial determinant of cellular function and viability.
Shenae L. Cafe, Brett Nixon, Heath Ecroyd, Heath Ecroyd, Jacinta H. Martin, David A. Skerrett-Byrne, Elizabeth G. Bromfield, Elizabeth G. Bromfield   +7 more
doaj   +1 more source

Calreticulin: Roles in Cell-Surface Protein Expression

Membranes, 2014
In order to perform their designated functions, proteins require precise subcellular localizations. For cell-surface proteins, such as receptors and channels, they are able to transduce signals only when properly targeted to the cell membrane ...
Yue Jiang, Sandeepa Dey, Hiroaki Matsunami   +2 more
doaj   +1 more source

HtrA chaperone activity contributes to host cell binding in Campylobacter jejuni

Gut Pathogens, 2011
Background Acute gastroenteritis caused by the food-borne pathogen Campylobacter jejuni is associated with attachment of bacteria to the intestinal epithelium and subsequent invasion of epithelial cells. In C.
Bæk Kristoffer T, Vegge Christina S, Brøndsted Lone   +2 more
doaj   +1 more source

The Chlamydia trachomatis Type III Secretion Chaperone Slc1 Engages Multiple Early Effectors, Including TepP, a Tyrosine-phosphorylated Protein Required for the Recruitment of CrkI-II to Nascent Inclusions and Innate Immune Signaling [PDF]

, 2014
Chlamydia trachomatis, the causative agent of trachoma and sexually transmitted infections, employs a type III secretion (T3S) system to deliver effector proteins into host epithelial cells to establish a replicative vacuole.
Bastidas, Robert J., Carpenter, Victoria K., Chen, Yi-Shan, Plano, Gregory V., Richards, Kristian L., Saka, Hector Alex, Valdivia, Raphael H.   +6 more
core   +3 more sources

Donor-strand exchange in chaperone-assisted pilus assembly revealed in atomic detail by molecular dynamics [PDF]

, 2008
Adhesive multi-subunit fibres are assembled on the surface of many pathogenic bacteria via the chaperone-usher pathway. In the periplasm, a chaperone donates a β-strand to a pilus subunit to complement its incomplete immunoglobulin-like fold.
Ashcroft, A.E., Paci, E., Radford, S.E., Rose, R.J., Waksman, G., Welsh, T.S.   +5 more
core   +1 more source

Extracellular Chaperones

, 2010
The maintenance of the levels and correct folding state of proteins (proteostasis) is a fundamental prerequisite for life. Life has evolved complex mechanisms to maintain proteostasis and many of these that operate inside cells are now well understood.
Dabbs, Rebecca A, Wyatt, Amy R, Yerbury, Justin J, Ecroyd, Heath, Wilson, Mark R   +4 more
openaire   +5 more sources

Proteostasis collapse, a hallmark of aging, hinders the chaperone-Start network and arrests cells in G1

eLife, 2019
Loss of proteostasis and cellular senescence are key hallmarks of aging, but direct cause-effect relationships are not well understood. We show that most yeast cells arrest in G1 before death with low nuclear levels of Cln3, a key G1 cyclin extremely ...
David F Moreno, Kirsten Jenkins, Sandrine Morlot, Gilles Charvin, Attila Csikasz-Nagy, Martí Aldea   +5 more
doaj   +1 more source

The structure of the PapD-PapGII pilin complex reveals an open and flexible P5 pocket [PDF]

, 2012
P pili are hairlike polymeric structures that mediate binding of uropathogenic Escherichia coli to the surface of the kidney via the PapG adhesin at their tips.
Baga M, Bann JG, Barnhart MM, Dodson KW, Dodson KW, Doublie S, Gong M, Griebling TL, Henderson NS, Hess B, Holmgren A, Hooton TM, Hultgren SJ, Hung DL, Hung DL, Hung DL, Jacob-Dubuisson F, Jones CH, Justice SS, Kabsch W, Knight SD, Kuehn MJ, Kuehn MJ, Leslie A, Martinez JJ, Munera D, Nishiyama M, Painter J, Pellecchia M, Phan G, Remaut H, Remaut H, Roberts JA, Roberts JA, Rose RJ, Sauer FG, Sauer FG, Sauer FG, Saulino ET, Saulino ET, Sheldrick GM, Slonim LN, Striker R, Stromberg N, Verger D, Verger D, Volkan E, Wright KJ, Zavialov AV   +48 more
core   +2 more sources

Cathepsin V regulates cell cycle progression and histone stability in the nucleus of breast cancer cells

Frontiers in Pharmacology, 2023
Introduction: We previously identified that Cathepsin V (CTSV) expression is associated with poor prognosis in ER+ breast cancer, particularly within the Luminal A subtype.
Naphannop Sereesongsaeng, James F. Burrows, Christopher J. Scott, Klaudia Brix, Roberta E. Burden   +4 more
doaj   +1 more source