Results 31 to 40 of about 226,086 (342)

Chaperoning erythropoiesis

Blood, 2009
AbstractMultisubunit complexes containing molecular chaperones regulate protein production, stability, and degradation in virtually every cell type. We are beginning to recognize how generalized and tissue-specific chaperones regulate specialized aspects of erythropoiesis.
Mitchell J, Weiss, Camila O, dos Santos
openaire   +3 more sources

AAA+: A class of chaperone-like ATPases associated with the assembly, operation, and disassembly of protein complexes.

Genome Research, 1999
Using a combination of computer methods for iterative database searches and multiple sequence alignment, we show that protein sequences related to the AAA family of ATPases are far more prevalent than reported previously.
A. F. Neuwald, L. Aravind, J. Spouge, E. Koonin   +3 more
semanticscholar   +1 more source

The DnaJK chaperone of Bacillus subtilis post-transcriptionally regulates gene expression through the YlxR(RnpM)/RNase P complex

mBio
To survive in harsh natural environments, translation and mRNA metabolism must be tightly and coordinately controlled, as saving biological costs increases fitness. However, the roles of protein chaperones in this control system are unclear.
Mitsuo Ogura, Yu Kanesaki, Hirofumi Yoshikawa, Koki Haga   +3 more
doaj   +1 more source

Long-Term Monitoring of Cardiac Involvement under Migalastat Treatment Using Magnetic Resonance Tomography in Fabry Disease

Life, 2023
Background: Fabry cardiomyopathy is characterized by left ventricular hypertrophy, myocardial fibrosis, arrhythmia, and premature death. Treatment with migalastat, an oral pharmacological chaperone, was associated with a stabilization of cardiac ...
Constantin Gatterer, Dietrich Beitzke, Senta Graf, Max Lenz, Gere Sunder-Plassmann, Christopher Mann, Markus Ponleitner, Robert Manka, Daniel Fritschi, Pierre-Alexandre Krayenbuehl, Philipp Kamm, Olivier Dormond, Frédéric Barbey, Pierre Monney, Albina Nowak   +14 more
doaj   +1 more source

Inhibitors of the AAA+ Chaperone p97

Molecules, 2015
It is remarkable that a pathway as ubiquitous as protein quality control can be targeted to treat cancer. Bortezomib, an inhibitor of the proteasome, was first approved by the US Food and Drug Administration (FDA) more than 10 years ago to treat ...
Eli Chapman, Nick Maksim, Fabian de la Cruz, James J. La Clair   +3 more
doaj   +1 more source

Mycobacterium tuberculosis Rv0991c Is a Redox-Regulated Molecular Chaperone

mBio, 2020
The bacterial pathogen Mycobacterium tuberculosis is the leading cause of death by an infectious disease among humans. Here, we describe a previously uncharacterized M.
Samuel H. Becker, Kathrin Ulrich, Avantika Dhabaria, Beatrix Ueberheide, William Beavers, Eric P. Skaar, Lakshminarayan M. Iyer, L. Aravind, Ursula Jakob, K. Heran Darwin   +9 more
doaj   +1 more source

Effects of Signal Peptide and Chaperone Co-Expression on Heterologous Protein Production in Escherichia coli

Molecules, 2023
Various host systems have been employed to increase the yield of recombinant proteins. However, some recombinant proteins were successfully produced at high yields but with no functional activities. To achieve both high protein yield and high activities,
Juntratip Jomrit, Suhardi Suhardi, Pijug Summpunn   +2 more
doaj   +1 more source

A Twist in Yeast: New Perspectives for Studying TDP-43 Proteinopathies in S. cerevisiae

Journal of Fungi
TAR DNA-binding protein 43 kDa (TDP-43) proteinopathies are a group of neurodegenerative diseases (NDs) characterized by the abnormal accumulation of the TDP-43 protein in neurons and glial cells.
Roberto Stella, Alessandro Bertoli, Raffaele Lopreiato, Caterina Peggion   +3 more
doaj   +1 more source

Amino-Terminal Processing of Helicobacter pylori Serine Protease HtrA: Role in Oligomerization and Activity Regulation

Frontiers in Microbiology, 2018
The HtrA family of serine proteases is found in most bacteria, and plays an essential role in the virulence of the gastric pathogen Helicobacter pylori. Secreted H.
Nicole Albrecht, Nicole Tegtmeyer, Heinrich Sticht, Joanna Skórko-Glonek, Steffen Backert   +4 more
doaj   +1 more source

Chaperone-mediated autophagy and endosomal microautophagy: Jointed by a chaperone

Journal of Biological Chemistry, 2017
A variety of mechanisms deliver cytosolic materials to the lysosomal compartment for degradation through autophagy. Here, we focus on two autophagic pathways, the chaperone-mediated autophagy and the endosomal microautophagy that rely on the cytosolic ...
Kumsal Tekirdag, A. Cuervo
semanticscholar   +1 more source